scholarly journals Metformin monotherapy significantly decreases epicardial adipose tissue thickness in newly diagnosed type 2 diabetes patients

2019 ◽  
Vol 38 (6) ◽  
pp. 419-423 ◽  
Author(s):  
Murat Ziyrek ◽  
Serkan Kahraman ◽  
Emrah Ozdemir ◽  
Ali Dogan
Keyword(s):  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Epicardial Adipose Tissue ◽  
Newly Diagnosed ◽  
Tissue Thickness ◽  
Epicardial Adipose Tissue Thickness ◽  
Metformin Monotherapy ◽  
Diabetes Patients

Epicardial adipose tissue thickness and type 2 diabetes risk according to the FINDRISC modified for Latin America

2019 ◽  
Vol 31 (1) ◽  
pp. 15-22
Author(s):  
Marcos M. Lima-Martínez ◽  
Leomar Colmenares ◽  
Yanei Campanelli ◽  
Mariela Paoli ◽  
Marianela Rodney ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Latin America ◽  
Epicardial Adipose Tissue ◽  
Diabetes Risk ◽  
Tissue Thickness ◽  
Epicardial Adipose Tissue Thickness

scholarly journals Increased Epicardial Adipose Tissue Thickness in Type 2 Diabetes Mellitus and Obesity

2015 ◽  
Vol 39 (5) ◽  
pp. 405 ◽  
Author(s):  
Do Kyeong Song ◽  
Young Sun Hong ◽  
Hyejin Lee ◽  
Jee-Young Oh ◽  
Yeon-Ah Sung ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Adipose Tissue ◽  
Epicardial Adipose Tissue ◽  
Tissue Thickness ◽  
Epicardial Adipose Tissue Thickness

Epicardial adipose tissue thickness and type 2 diabetes risk according to the FINDRISC modified for Latin America

2019 ◽  
Vol 31 (1) ◽  
pp. 15-22 ◽  
Author(s):  
Marcos M. Lima-Martínez ◽  
Leomar Colmenares ◽  
Yanei Campanelli ◽  
Mariela Paoli ◽  
Marianela Rodney ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Latin America ◽  
Epicardial Adipose Tissue ◽  
Diabetes Risk ◽  
Tissue Thickness ◽  
Epicardial Adipose Tissue Thickness

scholarly journals Effects of Semaglutide Versus Dulaglutide on Epicardial Fat Thickness in Subjects with Type 2 Diabetes and Obesity

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Gianluca Iacobellis ◽  
Alexandra C Villasante Fricke
Keyword(s):  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Epicardial Adipose Tissue ◽  
Statistical Significance ◽  
Control Group ◽  
Medication Regimen ◽  
Tissue Thickness ◽  
Receptor Agonists ◽  
Epicardial Adipose Tissue Thickness

Abstract Background and Aims Epicardial adipose tissue (EAT), the visceral fat depot of the heart, is a modifiable cardio-metbolic risk factor and therapeutic target. Semaglutide and dulaglutide, glucagon-like peptide-1 (GLP-1) receptor agonists, are indicated for the treatment of type 2 diabetes mellitus (T2DM). GLP-1 receptor agonists have recently shown to reduce cardiovascular risk. Epicardial adipose tissue expresses GLP-1 receptors (GLP-1Rs). GLP-1 receptor agonist liraglutide is known to significantly decrease EAT thickness. However, the effects of GLP-1 receptor agonists semaglutide and dulaglutide on EAT thickness are unknown. Materials and Methods We performed a 12-week, controlled, parallel study in 80 subjects with T2DM and obesity. Patients received either semaglutide, up to 1 mg subcutaneous (sc) weekly, or dulaglutide, up to 1.5 mg sc weekly, as the standard of care in addition to their usual medication regimen. Twenty subjects with T2DM and obesity were started on metformin and a diet and served as the control group. Ultrasound-measured EAT thickness was measured at baseline and at the 12-week follow-up. Results Epicardial adipose tissue thickness significantly decreased in both semaglutide and dulaglutide groups (P < 0.001) after 12 weeks, accounting for a 20% reduction. There was no EAT reduction in the metformin group. Body mass index (BMI) and HbA1c improved in all groups without reaching statistical significance. Epicardial adipose tissue thickness reduction was significantly greater (P < 0.01) with the higher doses of semaglutide (1 mg) and dulaglutide (1.5 mg), respectively. Conclusion Weekly administration of either GLP-1 receptor agonists semaglutide or dulaglutide causes a rapid, substantial, and dose-dependent reduction in EAT thickness.

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