Is octylphenol-induced disruption of adherens and gap junction proteins in bank vole testis photoperiod dependent?

2013 ◽  
Vol 13 ◽  
pp. 37-38
Author(s):  
Anna Hejmej ◽  
Katarzyna Chojnacka ◽  
Małgorzata Kotula-Balak ◽  
Ewelina Górowska ◽  
Marta Łydka
Keyword(s):  
Gap Junction ◽  
Bank Vole ◽  
Gap Junction Proteins ◽  
Junction Proteins

scholarly journals Photoperiod-Dependent Effects of 4-tert-Octylphenol on Adherens and Gap Junction Proteins in Bank Vole Seminiferous Tubules

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Anna Hejmej ◽  
Malgorzata Kotula-Balak ◽  
Katarzyna Chojnacka ◽  
Paulina Kuras ◽  
Marta Lydka-Zarzycka ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Gap Junction ◽  
Bank Vole ◽  
Connexin 43 ◽  
Biological Effects ◽  
Seminiferous Tubules ◽  
Long Term Treatment ◽  
Gap Junction Proteins ◽  
Junction Proteins

In the present study we evaluatedin vivoandin vitroeffects of 4-tert-octylphenol (OP) on the expression and distribution of adherens and gap junction proteins, N-cadherin,β-catenin, and connexin 43 (Cx43), in testes of seasonally breeding rodents, bank voles. We found that in bank vole testes expression and distribution of N-cadherin,β-catenin, and Cx43 were photoperiod dependent. Long-term treatment with OP (200 mg/kg b.w.) resulted in the reduction of junction proteins expressions (P<0.05,P<0.01) and their delocalization in the testes of males kept in long photoperiod, whereas in short-day animals slight increase of Cx43 (P<0.05), N-cadherin, andβ-catenin (statistically nonsignificant) levels was observed. Effects of OP appeared to be independent of FSH and were maintained duringin vitroorgan culture, indicating that OP acts directly on adherens and gap junction proteins in the testes. An experiment performed using an antiestrogen ICI 182,780 demonstrated that the biological effects of OP onβ-catenin and Cx43 involve an estrogen receptor-mediated response. Taken together, in bank vole organization of adherens and gap junctions and their susceptibility to OP are related to the length of photoperiod. Alterations in cadherin/catenin and Cx43-based junction may partially result from activation of estrogen receptorαand/orβsignaling pathway.

Innexin genes and gap junction proteins in the locust frontal ganglion

2009 ◽  
Vol 39 (3) ◽  
pp. 224-233 ◽  
Author(s):  
Sarit Anava ◽  
David Rand ◽  
Yael Zilberstein ◽  
Amir Ayali
Keyword(s):  
Gap Junction ◽  
Frontal Ganglion ◽  
Gap Junction Proteins ◽  
Junction Proteins

Gap-junction proteins and communication in human epidermis

Gap Junctions ◽  
1993 ◽  
pp. 225-231 ◽  
Author(s):  
D. SALOMON ◽  
E. MASGRAU ◽  
S. VISCHER ◽  
J.-H. SAURAT ◽  
M. CHANSON ◽  
...  
Keyword(s):  
Gap Junction ◽  
Human Epidermis ◽  
Gap Junction Proteins ◽  
Junction Proteins
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