Comments on the Spanish Society of Cardiology Critical Review of the ESC 2010 Clinical Practice Guidelines on Atrial Fibrillation

2012 ◽  
Vol 65 (4) ◽  
pp. 390-391
Author(s):  
Gregory Y.H. Lip ◽  
A. John Camm
Keyword(s):  
Atrial Fibrillation ◽  
Clinical Practice ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Critical Review ◽  
Spanish Society

scholarly journals A critical review to traumatic brain injury clinical practice guidelines

Medicine ◽  
2019 ◽  
Vol 98 (9) ◽  
pp. e14592 ◽  
Author(s):  
Bao-shan Di ◽  
Min Wei ◽  
Wen-juan Ma ◽  
Qi Zhang ◽  
An-qing Lu ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Clinical Practice ◽  
Brain Injury ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Critical Review

scholarly journals Amiodarone for Atrial Fibrillation Following Cardiac Surgery: Development of Clinical Practice Guidelines at a University Hospital

2008 ◽  
Vol 31 (1) ◽  
pp. 6-10 ◽  
Author(s):  
Ujjaini Khanderia ◽  
Deborah Wagner ◽  
Paul C. Walker ◽  
Brian Woodcock ◽  
Richard Prager
Keyword(s):  
Atrial Fibrillation ◽  
Cardiac Surgery ◽  
Clinical Practice ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
University Hospital

Primary Stroke Prevention in Nonvalvular Atrial Fibrillation: Implementing the Clinical Trial Findings

1997 ◽  
Vol 31 (10) ◽  
pp. 1187-1196 ◽  
Author(s):  
Patricia A Howard ◽  
Pamela W Duncan
Keyword(s):  
Atrial Fibrillation ◽  
Clinical Trial ◽  
Clinical Trials ◽  
Clinical Practice ◽  
Cost Effectiveness ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Randomized Clinical Trials ◽  
Nonvalvular Atrial Fibrillation ◽  
Risk Patients

OBJECTIVE: To review the clinical trials evaluating warfarin for primary stroke prophylaxis in nonvalvular atrial fibrillation (NVAF), to discuss the relative benefits and risks of warfarin versus aspirin therapy, and to review the clinical practice guidelines and identify potential barriers to their implementation in clinical practice. DATA SOURCES: A MEDLINE literature search was performed to identify clinical trials of antithrombotic therapy for NVAF, clinical practice guidelines, studies evaluating physician practices and attitudes, cost-effectiveness studies, and pertinent review articles. Key search terms included atrial fibrillation, stroke, antithrombotic, warfarin, aspirin, and cost-effectiveness. DATA EXTRACTION: Prospective, randomized clinical trials were selected for analysis. Clinical practice guidelines from recognized panels of experts were reviewed. Comprehensive review articles were selected. DATA SYNTHESIS: NVAF is a common arrhythmia that is associated with a substantial risk for stroke. Seven prospective, randomized, clinical trials have conclusively demonstrated the efficacy of warfarin for stroke prevention. The greatest benefits are achieved in older patients and those with comorbidities that increase their risk for stroke. The potential benefits of preventing a devastating stroke, however, must be weighed against the potential for bleeding complications. Warfarin has been shown to be cost-effective in high-risk patients, provided the rate of complications is minimized. Nonetheless, many physicians remain hesitant to implement warfarin therapy in older, high-risk patients. The clinical data on aspirin are less consistent than those observed with warfarin. Aspirin appears to be most effective in younger individuals or those considered to be at low risk for stroke. CONCLUSIONS: In patients with NVAF, the personal, social, and economic consequences of stroke are often devastating. Clinical trials have provided definitive proof that the risks of stroke can be significantly reduced through the use of appropriate antithrombotic therapy. Despite this evidence and the recommendations of a number of clinical practice guidelines, variations in care exist that continue to place patients at risk. Additional outcomes research is needed to evaluate the impact of the clinical trial findings and practice guidelines on clinical practice and to develop methods for overcoming barriers to implementation.

scholarly journals Critical review of current clinical practice guidelines for antifungal therapy in paediatric haematology and oncology

2016 ◽  
Vol 25 (1) ◽  
pp. 221-228 ◽  
Author(s):  
Jessica E Morgan ◽  
Hadeel Hassan ◽  
Julia V Cockle ◽  
Christopher Lethaby ◽  
Beki James ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Antifungal Therapy ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Critical Review ◽  
Current Clinical Practice ◽  
Paediatric Haematology
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