PDMS tri-block copolymers bearing quaternary ammonium salts for epidermal antimicrobial agents: Synthesis, surface adsorption and non-skin-penetration

2018 ◽  
Vol 124 ◽  
pp. 20-28 ◽  
Author(s):  
Yufeng Lei ◽  
Shengwen Zhou ◽  
Chenyun Dong ◽  
Anqiang Zhang ◽  
Yaling Lin
Keyword(s):  
Block Copolymers ◽  
Quaternary Ammonium ◽  
Antimicrobial Agents ◽  
Surface Adsorption ◽  
Skin Penetration ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts

ChemInform Abstract: Antimicrobial Agents. Part 6. Synthesis and Antimicrobial Activity of Some New Benzofuran Quaternary Ammonium Salts.

ChemInform ◽  
2010 ◽  
Vol 22 (31) ◽  
pp. no-no
Author(s):  
C. V. R. SASTRY ◽  
O. P. BANSAL ◽  
B. LAL ◽  
S. C. CHATURVEDI ◽  
J. S. SRINIVAS ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Quaternary Ammonium ◽  
Antimicrobial Agents ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts

scholarly journals Cu Nanoparticle-Loaded Nanovesicles with Antibiofilm Properties. Part I: Synthesis of New Hybrid Nanostructures

Nanomaterials ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1542 ◽  
Author(s):  
Lucia Sarcina ◽  
Pablo García-Manrique ◽  
Gemma Gutiérrez ◽  
Nicoletta Ditaranto ◽  
Nicola Cioffi ◽  
...  
Keyword(s):  
Quaternary Ammonium ◽  
Antimicrobial Agents ◽  
Aqueous Media ◽  
Quaternary Ammonium Salts ◽  
Hybrid Nanostructures ◽  
Ammonium Salts ◽  
Biofilm Inhibition ◽  
Transmission Electron ◽  
The Stability ◽  
A Charge

Copper nanoparticles (CuNPs) stabilized by quaternary ammonium salts are well known as antimicrobial agents. The aim of this work was to study the feasibility of the inclusion of CuNPs in nanovesicular systems. Liposomes are nanovesicles (NVs) made with phospholipids and are traditionally used as delivery vehicles because phospholipids favor cellular uptake. Their capacity for hydrophilic/hydrophobic balance and carrier capacity could be advantageous to prepare novel hybrid nanostructures based on metal NPs (Me-NPs). In this work, NVs were loaded with CuNPs, which have been reported to have a biofilm inhibition effect. These hybrid materials could improve the effect of conventional antibacterial agents. CuNPs were electro-synthesized by the sacrificial anode electrolysis technique in organic media and characterized in terms of morphology through transmission electron microscopy (TEM). The NVs were prepared by the thin film hydration method in aqueous media, using phosphatidylcholine (PC) and cholesterol as a membrane stabilizer. The nanohybrid systems were purified to remove non-encapsulated NPs. The size distribution, morphology and stability of the NV systems were studied. Different quaternary ammonium salts in vesicular systems made of PC were tested as stabilizing surfactants for the synthesis and inclusion of CuNPs. The entrapment of charged metal NPs was demonstrated. NPs attached preferably to the membrane, probably due to the attraction of their hydrophobic shell to the phospholipid bilayers. The high affinity between benzyl-dimethyl-hexadecyl-ammonium chloride (BDHAC) and PC allowed us to obtain stable hybrid NVs c.a. 700 nm in diameter. The stability of liposomes increased with NP loading, suggesting a charge-stabilization effect in a novel antibiofilm nanohybrid material.

scholarly journals Sustainable triazine-derived quaternary ammonium salts as antimicrobial agents

RSC Advances ◽  
2021 ◽  
Vol 11 (45) ◽  
pp. 28092-28096
Author(s):  
Andrea Morandini ◽  
Emanuele Spadati ◽  
Benedetta Leonetti ◽  
Roberto Sole ◽  
Vanessa Gatto ◽  
...  
Keyword(s):  
Quaternary Ammonium ◽  
Antimicrobial Agents ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts ◽  
Highly Efficient

The first examples of highly efficient antimicrobial triazine-derived bis imidazolium quaternary ammonium salts (TQAS) are reported.

Synthesis and stability of 1-aminoalkylphosphonic acid quaternary ammonium salts

2021 ◽  
Author(s):  
Tomasz K. Olszewski ◽  
Anna Brol
Keyword(s):  
Phosphonic Acid ◽  
Quaternary Ammonium ◽  
Alkylating Agent ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts ◽  
Aminoalkylphosphonic Acid

An effective protocol for quaternization of simple 1-aminoalkylphosphonic acids under basic conditions and using Me2SO4 as convenient alkylating agent is reported. In the course of reaction phosphonic acid quaternary ammonium...

scholarly journals Green Accelerated Synthesis, Antimicrobial Activity and Seed Germination Test of Quaternary Ammonium Salts of 1,2-bis(4-pyridyl)ethane

Molecules ◽  
2019 ◽  
Vol 24 (13) ◽  
pp. 2424 ◽  
Author(s):  
Tăbăcaru ◽  
Botezatu ◽  
Horincar ◽  
Furdui ◽  
Dinică
Keyword(s):  
Escherichia Coli ◽  
Triticum Aestivum ◽  
Seed Germination ◽  
Quaternary Ammonium ◽  
Pathogenic Bacteria ◽  
Classical Method ◽  
Triticum Aestivum L ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts ◽  
Radicle Growth

A family of fifteen quaternary ammonium salts (QAs), bearing the 1,2-bis(4-pyridyl)ethane core, were obtained using for the first time two different green methods, such as microwave (MW) and ultrasounds (US) irradiation, with very good yields and in much shorter times compared to the classical method, and an assay on their antimicrobial action against Escherichia coli (E. coli) was carried out. While 12 to 24 hours were required for complete alkylation of 1,2-bis(4-pyridyl)ethane by reactive halogenated derivatives in anhydrous solvent under reflux conditions, MW and US irradiation reduced the reaction time and the desired products were achieved in a few min. One of the aims of this study was to evaluate the antibacterial potential of the synthesized QAs against pathogenic bacteria, along with their impact on germination activity of wheat seeds (Triticum aestivum L.). The antibacterial activity of the QAs against Escherichia coli was explored by determining the minimum inhibitory concentration (MIC). The MIC values varied from 0.312 to 2.5 mg/mL, highlighting the lowest values attained for the derivatives containing methoxy, chlorine and benzofurane functional groups. The viability of aerobic bacteria was determined with the Tetrazolium/Formazan Test, a method that was found to be the best alternative approach with respect to the difuzimetric method. Seeds of Triticum aestivum L. were used for the evaluation of the germination indicators, such as seed germination (SG), the relative seed germination (RSG), the relative radicle growth (RRG), and the seed germination index (GI). The toxicity studies of QAs 1, 4 and 7, at two different concentrations, showed no inhibitory effect on seed germination.

Interaction of water-insoluble quaternary ammonium salts with the hydrated silica surface

1996 ◽  
Vol 32 (6) ◽  
pp. 331-334
Author(s):  
V. V. Turov ◽  
O. A. Zaporozhets ◽  
O. Yu. Nadzhafova ◽  
V. V. Sukhan
Keyword(s):  
Quaternary Ammonium ◽  
Silica Surface ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts ◽  
Hydrated Silica
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