Controlled delivery of oral insulin aspart using pH-responsive alginate/κ-carrageenan composite hydrogel beads

2017 ◽  
Vol 120 ◽  
pp. 20-29 ◽  
Author(s):  
Hui-Peng Lim ◽  
Chien-Wei Ooi ◽  
Beng-Ti Tey ◽  
Eng-Seng Chan
Keyword(s):  
Insulin Aspart ◽  
Composite Hydrogel ◽  
Controlled Delivery ◽  
Oral Insulin ◽  
Ph Responsive ◽  
Hydrogel Beads

scholarly journals Preparation and application of pH-responsive composite hydrogel beads as potential delivery carrier candidates for controlled release of berberine hydrochloride

2020 ◽  
Vol 7 (11) ◽  
pp. 200676
Author(s):  
Jiande Gao ◽  
Dongying Fan ◽  
Ping Song ◽  
Shudan Zhang ◽  
Xiong Liu
Keyword(s):  
Composite Hydrogel ◽  
Swelling Ratio ◽  
Ph Responsive ◽  
X Ray Diffraction ◽  
Swelling Properties ◽  
Pharmaceutical Dosage Forms ◽  
Berberine Hydrochloride ◽  
X Ray ◽  
Hydrogel Beads ◽  
Cumulative Release

For improving the effective concentration of berberine hydrochloride (BH) in the gastrointestinal tract, a series of pH-responsive hydrogel beads were prepared based on carboxymethylstarch-g-poly (acrylic acid)/palygorskite/starch/sodium alginate (CMS-g-PAA/PGS/ST/SA) in the present work. The developed hydrogel beads were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TG). Effect of palygorskite (PGS) content on the swelling properties of hydrogel beads and BH cumulative release were discussed. The pH responsiveness of hydrogel beads was also investigated in different media. Results illustrated that swelling of hydrogel beads and BH cumulative release from hydrogel beads were obviously affected by PGS content. The swelling ratio and BH cumulative release of composite hydrogel beads remarkably slowed down with PGS content increasing in the range from 10 to 40 wt%. The composite hydrogel beads were pH-responsive. At pH 7.4, the swelling ratio and BH cumulative release from composite hydrogel beads were the fastest among the dissolution media of pH 1.2, pH 6.8 and pH 7.4. The BH cumulative release from hydrogel beads was related to the swelling and relaxation of composite hydrogel beads and could be fitted better by the Higuchi model. The obtained composite hydrogel beads could be potentially used for the development of BH pharmaceutical dosage forms.

Novel thermo- and pH-responsive hydroxypropyl cellulose- and poly (l-glutamic acid)-based microgels for oral insulin controlled release

2012 ◽  
Vol 89 (4) ◽  
pp. 1207-1214 ◽  
Author(s):  
Yunyan Bai ◽  
Zhe Zhang ◽  
Aiping Zhang ◽  
Li Chen ◽  
Chaoliang He ◽  
...  
Keyword(s):  
Controlled Release ◽  
Glutamic Acid ◽  
Hydroxypropyl Cellulose ◽  
Oral Insulin ◽  
Ph Responsive

Magnetic and pH responsive composite hydrogel-based on poly(2-(diethylamino)ethyl methacrylate)/chitosan for fipronil removal from aqueous medium

2021 ◽  
Vol 168 ◽  
pp. 105050
Author(s):  
Marcella Matos Cordeiro Borges ◽  
Bruna Carneiro Pires ◽  
Sara Silveira Vieira ◽  
Keyller Bastos Borges ◽  
Luiz Gustavo de Lima Guimarães
Keyword(s):  
Aqueous Medium ◽  
Composite Hydrogel ◽  
Ph Responsive ◽  
Ethyl Methacrylate

Fabrication of an efficient ZIF-8 alginate composite hydrogel material and its application for enhanced copper (II) adsorption from aqueous solutions

2021 ◽  
Author(s):  
Xiao Zhang ◽  
Zhiyue Li ◽  
Taoyi Zhang ◽  
Jing Chen ◽  
Wenxi Ji ◽  
...  
Keyword(s):  
Aqueous Solutions ◽  
Sodium Alginate ◽  
Composite Hydrogel ◽  
Alginate Hydrogel ◽  
Zeolitic Imidazolate Framework ◽  
Composite Bead ◽  
Hydrogel Beads

A novel zeolitic imidazolate framework-8 (ZIF-8) alginate composite hydrogel material (PVA/SA@ZIF-8) is alginate composite bead which was fabricated by grafting ZIF-8 on the surface of the sodium alginate hydrogel beads...

scholarly journals All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery

2020 ◽  
Vol 8 (12) ◽  
pp. 3270-3277 ◽  
Author(s):  
Clarinda Costa ◽  
Zehua Liu ◽  
João P. Martins ◽  
Alexandra Correia ◽  
Patrícia Figueiredo ◽  
...  
Keyword(s):  
Delivery System ◽  
Insulin Delivery ◽  
Oral Insulin ◽  
Ph Responsive ◽  
Glass Capillary ◽  
Promising Alternative ◽  
The Common ◽  
Insulin Delivery System ◽  
Microfluidic Assembly ◽  
Microfluidic Technique

Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral insulin delivery system is reported. This system represents a promising alternative for the common protein/peptide-loaded liposome formulations.

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