Optimization of pH-responsive carboxymethylated iota -carrageenan/chitosan nanoparticles for oral insulin delivery using response surface methodology

2017 ◽  
Vol 119 ◽  
pp. 145-155 ◽  
Author(s):  
Pratyusa Sahoo ◽  
Kok Hoong Leong ◽  
Shaik Nyamathulla ◽  
Yoshinori Onuki ◽  
Kozo Takayama ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Chitosan Nanoparticles ◽  
Insulin Delivery ◽  
Oral Insulin ◽  
Ph Responsive

Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery

Biomaterials ◽  
2009 ◽  
Vol 30 (29) ◽  
pp. 5691-5700 ◽  
Author(s):  
Lichen Yin ◽  
Jieying Ding ◽  
Chunbai He ◽  
Liming Cui ◽  
Cui Tang ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
Insulin Delivery ◽  
Oral Insulin ◽  
Drug Permeability ◽  
Trimethyl Chitosan

Preparation and Optimization of Capsaicin-Loaded Chitosan Nanoparticles as Delivery Systems Using Box-Behnken Design

2020 ◽  
Vol 998 ◽  
pp. 277-282
Author(s):  
Narissara Kulpreechanan ◽  
Feuangthit N. Sorasitthiyanukarn
Keyword(s):  
Response Surface Methodology ◽  
Experimental Design ◽  
Response Surface ◽  
Functional Foods ◽  
Water Solubility ◽  
Chitosan Nanoparticles ◽  
Tween 80 ◽  
Limiting Factors ◽  
Design And Optimization ◽  
Chili Peppers

Capsaicin (CAP) is a pungent alkaloid of chili peppers that is obtained from chili peppers that has a variety of pharmacological activities and can be used in various areas, such as functional foods, nutritional supplements and medical nutrition. Capsaicin has important anticancer, antioxidant and anti-inflammatory properties that allow to be applied as treatment for several diseases. However, its lack of water solubility, as well as its poor oral bioavailability in biological systems, show limiting factors for its successful application. Recently, the formulation of capsaicin for food and pharmaceutical use is limited. Therefore, the present study emphasized on preparation of capsaicin-loaded chitosan nanoparticles (CAP-CSNPs) and design and optimization of the formulation using Box-Behnken experimental design (BBD) and response surface methodology (RSM). The capsaicin-loaded chitosan nanoparticles were prepared by o/w emulsification and ionotropic gelification. The optimized formulation of capsaicin-loaded chitosan nanoparticles had a chitosan concentration of 0.11 (%w/v), a Tween 80® concentration of 1.55 (%w/v) and a CAP concentration of 1 mg/mL and that it should be stored at 4°C. Box-Behnken experimental design and response surface methodology was found to be a powerful technique for design and optimization of the preparation of capsaicin-loaded chitosan nanoparticles using limited number of experimental runs. Our study demonstrated that capsaicin-loaded chitosan nanoparticles can be potentially utilized as dietary supplements, nutraceuticals and functional foods.

scholarly journals All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery

2020 ◽  
Vol 8 (12) ◽  
pp. 3270-3277 ◽  
Author(s):  
Clarinda Costa ◽  
Zehua Liu ◽  
João P. Martins ◽  
Alexandra Correia ◽  
Patrícia Figueiredo ◽  
...  
Keyword(s):  
Delivery System ◽  
Insulin Delivery ◽  
Oral Insulin ◽  
Ph Responsive ◽  
Glass Capillary ◽  
Promising Alternative ◽  
The Common ◽  
Insulin Delivery System ◽  
Microfluidic Assembly ◽  
Microfluidic Technique

Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral insulin delivery system is reported. This system represents a promising alternative for the common protein/peptide-loaded liposome formulations.

scholarly journals Oral insulin delivery by carboxymethyl-β-cyclodextrin-grafted chitosan nanoparticles for improving diabetic treatment

2018 ◽  
Vol 46 (sup3) ◽  
pp. S774-S782 ◽  
Author(s):  
Mingming Song ◽  
Hui Wang ◽  
Kuanmin Chen ◽  
Song Zhang ◽  
Lizhen Yu ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
Insulin Delivery ◽  
Oral Insulin ◽  
Diabetic Treatment

Oral insulin delivery by self-assembled chitosan nanoparticles: In vitro and in vivo studies in diabetic animal model

2013 ◽  
Vol 33 (1) ◽  
pp. 376-382 ◽  
Author(s):  
Piyasi Mukhopadhyay ◽  
Kishor Sarkar ◽  
Mousumi Chakraborty ◽  
Sourav Bhattacharya ◽  
Roshnara Mishra ◽  
...  
Keyword(s):  
Animal Model ◽  
Chitosan Nanoparticles ◽  
Insulin Delivery ◽  
Diabetic Animal ◽  
In Vivo Studies ◽  
Oral Insulin ◽  
Self Assembled

scholarly journals Alginate/Chitosan Nanoparticles are Effective for Oral Insulin Delivery

2007 ◽  
Vol 24 (12) ◽  
pp. 2198-2206 ◽  
Author(s):  
B. Sarmento ◽  
A. Ribeiro ◽  
F. Veiga ◽  
P. Sampaio ◽  
R. Neufeld ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
Insulin Delivery ◽  
Oral Insulin
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