On-demand drug delivery from temperature-responsive polyurethane membrane

2011 ◽  
Vol 71 (4) ◽  
pp. 525-535 ◽  
Author(s):  
Yi Chen ◽  
Rui Wang ◽  
Jian Zhou ◽  
Haojun Fan ◽  
Bi Shi
Keyword(s):  
Drug Delivery ◽  
Temperature Responsive ◽  
On Demand ◽  
Polyurethane Membrane

scholarly journals Remote Temperature-Responsive Parafilm Dermal Patch for On-Demand Topical Drug Delivery

Micromachines ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 975
Author(s):  
Shahrukh Zaman Akash ◽  
Farjana Yesmin Lucky ◽  
Murad Hossain ◽  
Asim Kumar Bepari ◽  
G. M. Sayedur Rahman ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Burst Release ◽  
Therapeutic Effects ◽  
Microbial Infection ◽  
Temperature Responsive ◽  
On Demand

The development of externally controlled drug delivery systems that can rapidly trigger drug release is widely expected to change the landscape of future drug carriers. In this study, a drug delivery system was developed for on-demand therapeutic effects. The thermoresponsive paraffin film can be loaded on the basis of therapeutic need, including local anesthetic (lidocaine) or topical antibiotic (neomycin), controlled remotely by a portable mini-heater. The application of mild temperature (45 °C) to the drug-loaded paraffin film allowed a rapid stimulus response within a short time (5 min). This system exploits regular drug release and the rapid generation of mild heat to trigger a burst release of 80% within 6 h of any locally administered drug. The in vitro drug release studies and in vivo therapeutic activity were observed for local anesthesia and wound healing using a neomycin-loaded film. The studies demonstrated on-demand drug release with minimized inflammation and microbial infection. This temperature-responsive drug-loaded film can be triggered remotely to provide flexible control of dose magnitude and timing. Our preclinical studies on these remotely adjustable drug delivery systems can significantly improve patient compliance and medical practice.

A thermosensitive material coated resonant stent for drug delivery on demand

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Victor Bradley Bednar ◽  
Kenichi Takahata
Keyword(s):  
Drug Delivery ◽  
On Demand

Wetting transition in nanochannels for biomimetic free-blocking on-demand drug transport

2018 ◽  
Vol 6 (39) ◽  
pp. 6269-6277 ◽  
Author(s):  
Yaya Cheng ◽  
Xiangyu Jiao ◽  
Liang Zhao ◽  
Yang Liu ◽  
Fang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Transport ◽  
Mesoporous Silica Nanoparticles ◽  
Wetting Transition ◽  
On Demand ◽  
Inner Surface

Inspired by aquaporins in nature, herein, a biomimetic free-blocking on-demand drug delivery system is proposed, which is constructed by controlling the wettability of the inner surface of nanochannels on mesoporous silica nanoparticles (MSNs).

scholarly journals Advances in Functional Metal‐Organic Frameworks Based On‐Demand Drug Delivery Systems for Tumor Therapeutics

2021 ◽  
pp. 2100014
Author(s):  
Bhanu Nirosha Yalamandala ◽  
Wei‐Ting Shen ◽  
Sheng‐Hao Min ◽  
Wen‐Hsuan Chiang ◽  
Shing‐Jyh Chang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Metal Organic Frameworks ◽  
Delivery Systems ◽  
On Demand ◽  
Metal Organic

scholarly journals Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

2021 ◽  
Vol 9 (1) ◽  
pp. 38-50
Author(s):  
Hien Phan ◽  
Vincenzo Taresco ◽  
Jacques Penelle ◽  
Benoit Couturaud
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Amphiphilic Block Copolymers ◽  
Stimuli Responsive ◽  
Site Specific ◽  
On Demand ◽  
Redox Agents

Stimuli-responsive amphiphilic block copolymers obtained by PISA have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, redox agents, light or temperature.

Temperature-Responsive Graft Copolymer Hydrogels for Controlled Swelling and Drug Delivery

2013 ◽  
Vol 11 (3) ◽  
pp. 294-304 ◽  
Author(s):  
Derek J. Overstreet ◽  
Ryan Y. McLemore ◽  
Brandon D. Doan ◽  
Amye Farag ◽  
Brent L. Vernon
Keyword(s):  
Drug Delivery ◽  
Graft Copolymer ◽  
Temperature Responsive

Reversibly pH-responsive polyurethane membranes for on-demand intravaginal drug delivery

2017 ◽  
Vol 47 ◽  
pp. 100-112 ◽  
Author(s):  
Seungil Kim ◽  
Yufei Chen ◽  
Emmanuel A. Ho ◽  
Song Liu
Keyword(s):  
Drug Delivery ◽  
Ph Responsive ◽  
On Demand ◽  
Polyurethane Membranes

On-demand shape transformation of polymer vesicles via site-specific isomerization of hydrazone photoswitches in monodisperse hydrophobic oligomers

2021 ◽  
Author(s):  
Valene Wang ◽  
Jiwon Kim ◽  
Junyoung Kim ◽  
Seul Woo Lee ◽  
Kyoung Taek Kim
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Conformational Change ◽  
Self Assembly ◽  
Shape Control ◽  
Shape Transformation ◽  
Site Specific ◽  
On Demand ◽  
Polymer Vesicles

The shape control of nanostructures formed by the solution self-assembly of block copolymers is of significance for drug delivery. In particular, site-specific perturbation resulting in the conformational change of the...

scholarly journals Biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Ali Tamayol ◽  
Alireza Hassani Najafabadi ◽  
Pooria Mostafalu ◽  
Ali K. Yetisen ◽  
Mattia Commotto ◽  
...  
Keyword(s):  
Drug Delivery ◽  
On Demand
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