Effect of human embryonic morphological development on fetal growth parameters: the Rotterdam Periconceptional Cohort (Predict Study)

2019 ◽  
Vol 38 (4) ◽  
pp. 613-620
Author(s):  
Francesca Parisi ◽  
Melek Rousian ◽  
Anton H.J. Koning ◽  
Sten P. Willemsen ◽  
Eric A.P. Steegers ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Growth Parameters ◽  
Morphological Development ◽  
Predict Study

scholarly journals The Effect of Size and Asymmetry at Birth on Brain Injury and Neurodevelopmental Outcomes in Congenital Heart Disease

2021 ◽  
Author(s):  
Shalin A. Parekh ◽  
Stephany M. Cox ◽  
A. James Barkovich ◽  
Vann Chau ◽  
Martina A. Steurer ◽  
...  
Keyword(s):  
Brain Injury ◽  
Brain Development ◽  
Fetal Growth ◽  
Infant Development ◽  
Growth Parameters ◽  
Brain Mri ◽  
White Matter Injury ◽  
High Risk Infant ◽  
Neurodevelopmental Outcomes ◽  
Transposition Of Great Arteries

AbstractPoor and asymmetric fetal growth have been associated with neonatal brain injury (BI) and worse neurodevelopmental outcomes (NDO) in the growth-restricted population due to placental insufficiency. We tested the hypothesis that postnatal markers of fetal growth (birthweight (BW), head circumference (HC), and head to body symmetry) are associated with preoperative white matter injury (WMI) and NDO in infants with single ventricle physiology (SVP) and d-transposition of great arteries (TGA). 173 term newborns (106 TGA; 67 SVP) at two sites had pre-operative brain MRI to assess for WMI and measures of microstructural brain development. NDO was assessed at 30 months with the Bayley Scale of Infant Development-II (n = 69). We tested the association between growth parameters at birth with the primary outcome of WMI on the pre-operative brain MRI. Secondary outcomes included measures of NDO. Newborns with TGA were more likely to have growth asymmetry with smaller heads relative to weight while SVP newborns were symmetrically small. There was no association between BW, HC or asymmetry and WMI on preoperative brain MRI or with measures of microstructural brain development. Similarly, growth parameters at birth were not associated with NDO at 30 months. In a multivariable model only cardiac lesion and site were associated with NDO. Unlike other high-risk infant populations, postnatal markers of fetal growth including head to body asymmetry that is common in TGA is not associated with brain injury or NDO. Lesion type appears to play a more important role in NDO in CHD.

scholarly journals Lithium exposure during pregnancy increases fetal growth

2020 ◽  
pp. 026988112094091
Author(s):  
Eline MP Poels ◽  
Karin Sterrenburg ◽  
André I Wierdsma ◽  
Richard Wesseloo ◽  
Annemerle Beerthuizen ◽  
...  
Keyword(s):  
Birth Weight ◽  
Confidence Interval ◽  
Fetal Growth ◽  
Head Circumference ◽  
Growth Parameters ◽  
Abdominal Circumference ◽  
Average Increase ◽  
Femur Length ◽  
Pregnancy And Postpartum ◽  
The Impact

Background: Lithium is an effective treatment in pregnancy and postpartum for the prevention of relapse in bipolar disorder, but there is a lack of knowledge about the potential adverse impact on fetal development. Aims: To investigate the impact of lithium exposure on early fetal growth. Methods: In this retrospective observational cohort study, we included all singleton pregnancies of women using lithium and referred for advanced fetal ultrasound scanning between 1994 and 2018 to the University Medical Centers in Leiden and Rotterdam, the Netherlands ( n=119). The Generation R study, a population-based cohort, served as a non-exposed control population from the same geographic region ( n=8184). Fetal head circumference, abdominal circumference, femur length, and transcerebellar diameter were measured by ultrasound at 18–22 weeks of gestation. Results: Lithium use during pregnancy was associated with an average increase in head circumference of 1.77 mm (95% confidence interval: 0.53, 3.01), in abdominal circumference of 5.54 mm (95% confidence interval: 3.95, 7.12) and in femur length of 0.59 mm (95% confidence interval: 0.22, 0.96) at 18–22 weeks gestation. Furthermore, lithium use during pregnancy was associated with an average increase in birth weight of 142.43 grams (95% confidence interval: 58.01, 226.89), whereas it was associated with an average decrease of 1.41 weeks in gestational duration (95% confidence interval: −1.78, −1.05). Conclusions: Lithium use during pregnancy was associated with increased fetal growth parameters at 18–22 weeks gestational age and increased birth weight. Further research is needed to evaluate both short- and long-term implications, as well as the mechanisms driving this difference in growth.

scholarly journals Phthalate Levels in Cord Blood Are Associated with Preterm Delivery and Fetal Growth Parameters in Chinese Women

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e87430 ◽  
Author(s):  
Yujing Huang ◽  
Junnan Li ◽  
Jose M. Garcia ◽  
Hui Lin ◽  
Yanzhou Wang ◽  
...  
Keyword(s):  
Cord Blood ◽  
Preterm Delivery ◽  
Fetal Growth ◽  
Growth Parameters ◽  
Chinese Women

Estimating fetal age: computer-assisted analysis of multiple fetal growth parameters.

Radiology ◽  
1984 ◽  
Vol 152 (2) ◽  
pp. 497-501 ◽  
Author(s):  
F P Hadlock ◽  
R L Deter ◽  
R B Harrist ◽  
S K Park
Keyword(s):  
Fetal Growth ◽  
Growth Parameters ◽  
Computer Assisted ◽  
Assisted Analysis

First-trimester maternal serum levels of placental hormones are independent predictors of second-trimester fetal growth parameters

2006 ◽  
Vol 27 (2) ◽  
pp. 156-161 ◽  
Author(s):  
T. Y. Leung ◽  
L. W. Chan ◽  
T. N. Leung ◽  
T. Y. Fung ◽  
D. S. Sahota ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Growth Parameters ◽  
Serum Levels ◽  
First Trimester ◽  
Maternal Serum ◽  
Second Trimester

scholarly journals Placental Thickness and Its Correlation with Gestational Age: A Cross-sectional Ultrasonographic Study

2018 ◽  
Vol 6 (2) ◽  
Author(s):  
Sumnima Acharya ◽  
Awadesh Tiwari ◽  
Rupesh Sharma
Keyword(s):  
Fetal Growth ◽  
Gestational Age ◽  
Growth Parameters ◽  
Pearson Correlation ◽  
Abdominal Circumference ◽  
Cross Sectional ◽  
Positive Correlation ◽  
Reliable Parameter ◽  
The Difference ◽  
Placental Thickness

Introduction: Placenta grows in size with the advancement of gestational age (GA) and plays an important role for delivery of nutrients from mother to fetus. Ultrasonography (USG) is implicated for the estimation of GA by using fetal growth parameters like Femur Length (FL), Bi-parietal Diameter (BPD), Head Circumference (HC), and Abdominal Circumference (AC). This study intends to observe the correlation between Placental Thickness (PT) and GA. Methods: It was an observational, cross-sectional, and analytical study conducted over a period of six months from November 2017 to April 2018. Fetal growth parameters i.e. FL, BPD, HC, and AC were measured to estimate GA. PT was also measured at the same time. Results: There was a positive correlation between PT and GA (r = 0.89, n=249, p < 0.001). Pearson correlation coefficient between the two variables at second and third trimesters were 0.81 and 0.49 respectively. Fisher r-to-z transformation was used to analyze the difference between those two coefficients and was found to be statistically significant (z = 4.6, p < 0.001). This indicates that there was a significant overall relationship between PT and GA. As GA increases, PT also increases. Conclusion: Our study observed a positive correlation between the PT and GA in second and third trimesters. Thickness of placenta can thus be used as a reliable parameter for the estimation of GA during the second and third trimesters, and can be used as a supplementary USG parameter along with FL, BPD, HC and AC.

scholarly journals The Influence of Fasting in Summer on Amniotic Fluid During Pregnancy

2016 ◽  
Vol 6 ◽  
pp. 21
Author(s):  
Ayşegül Altunkeser ◽  
Muslu Kazım Körez
Keyword(s):  
Amniotic Fluid ◽  
Pregnant Women ◽  
Fetal Growth ◽  
Growth Parameters ◽  
Fluid Volume ◽  
Control Group ◽  
Growth Data ◽  
Amniotic Fluid Index ◽  
Amniotic Fluid Volume ◽  
Significant Difference

Objectives: Ramadan is a holy month in which eating and drinking are forbidden from dawn to sunset. In this study, we investigated using ultrasonography (USG) whether fasting in summer (as occurred in Ramadan 2014) had an influence on the volume of amniotic fluid during pregnancy. Materials and Methods: The study included 119 pregnant women in total who were admitted to our department with a request of obstetric USG between June 28, 2014, and July 27, 2014. The fasting group included 61 pregnant women and the control group of 58 pregnant women. In our study, all the fasting pregnant women had Sahur (predawn meal eaten before starting fasting) and Iftar (the evening meal for fast-breaking) every day, regularly. The women in the control group did not fast. In addition to amniotic fluid index and fetal biometric measurements during Ramadan, amniotic fluid volume was measured ultrasonographically throughout pregnancy. All ultrasound examinations were performed at least 8 h after Sahur during Ramadan. Chi-square test was utilized to compare the measurements of amniotic fluid volume, and Mann–Whitney U-test was utilized to analyze the differences in fetal growth data. Moreover, difference was considered statistically significant when the P value was <0.05. Results: The mean age was 25.7 years in the fasting group and 25.8 years in the control group. Other characteristics and mean gestational weeks of the two groups were similar. Ultrasonographically, there was no significant difference between two groups in respect to amniotic fluid amount during pregnancy (P = 0.7). There was no significant difference with regard to fetal growth parameters either (P > 0.05). Conclusion: In pregnant women who had regular predawn and fast-breaking meals, fasting in summer did not elicit alteration in the amount of amniotic fluid throughout pregnancy.

Evaluation of Applicability of Standard Growth Curves to Indian Women by Fetal Biometry

2009 ◽  
Vol 1 (3) ◽  
pp. 55-61 ◽  
Author(s):  
Ashini Acharya ◽  
Prashant Acharya
Keyword(s):  
Fetal Growth ◽  
Indian Population ◽  
Growth Parameters ◽  
Growth Curves ◽  
Abdominal Circumference ◽  
Correct Prediction ◽  
Indian Women ◽  
Fetal Biometry ◽  
Intrauterine Growth ◽  
Biparietal Diameter

ABSTRACT Objective To verify the applicability of standard fetal growth curves proposed for western populations to an Indian population. Method Thirty patients were included and ultrasound scans were performed on Indian pregnant women to measure fetal growth parameters of biparietal diameter, head circumference, abdominal circumference and femur length for every weekly interval from 14 to 40 weeks. Twenty-five hundred women had ultrasonic measurements of fetal BPD, HC, AC and FL between 12 to 42 weeks of pregnancy were also included in study for confirming the growth parameters and plotting of Growth curves. The data were compared with the commonly recommended standards of Hadlock, Campbell, Jeanty and Chitty. Results First and second trimester biometry findings are comparable to western charts but none of the standard charts agreed with the data in the present study particularly in third trimester. Conclusion Since most parameters of the standard growth curves developed in the west are not applicable for assessing the intrauterine growth of Indian babies we have developed growth curves for the Indian population to prevent over-diagnosis of intrauterine growth retardation and correct prediction of fetal age in Indian population.

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