Is subclinical hypothyroidism associated with lower live birth rates in women who have experienced unexplained recurrent miscarriage?

2016 ◽  
Vol 33 (6) ◽  
pp. 745-751 ◽  
Author(s):  
Myrthe M. van Dijk ◽  
Rosa Vissenberg ◽  
Peter H. Bisschop ◽  
Feroza Dawood ◽  
Madelon van Wely ◽  
...  
Keyword(s):  
Live Birth ◽  
Subclinical Hypothyroidism ◽  
Recurrent Miscarriage ◽  
Birth Rates ◽  
Live Birth Rates ◽  
Unexplained Recurrent Miscarriage

Live birth rates followingin vitrofertilization in women with thyroid autoimmunity and/or subclinical hypothyroidism

2013 ◽  
Vol 80 (1) ◽  
pp. 122-127 ◽  
Author(s):  
Joyce Chai ◽  
Wing-Yee T. Yeung ◽  
Chi-Yan V. Lee ◽  
Hang-Wun R. Li ◽  
Pak-Chung Ho ◽  
...  
Keyword(s):  
Live Birth ◽  
Subclinical Hypothyroidism ◽  
Thyroid Autoimmunity ◽  
Birth Rates ◽  
Live Birth Rates

scholarly journals Live Birth Rates after Active Immunization with Partner Lymphocytes

Biomedicines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1350
Author(s):  
Veronika Günther ◽  
Ibrahim Alkatout ◽  
Lisa Meyerholz ◽  
Nicolai Maass ◽  
Siegfried Görg ◽  
...  
Keyword(s):  
Live Birth ◽  
Recurrent Miscarriage ◽  
Active Immunization ◽  
Birth Rates ◽  
Live Births ◽  
Live Birth Rates ◽  
History Of ◽  
The Difference ◽  
Immunological Risk Factors ◽  
Routine Therapy

Although many potential causes have been established for recurrent implantation failure (RIF) and recurrent miscarriage (RM), about 50% of these remain idiopathic. Scientific research is focused on immunological risk factors. In the present study, we aim to evaluate live birth rates after immunization with paternal lymphocytes (lymphocyte immunotherapy (LIT)). This retrospective study consisted of 148 couples with a history of RM and/or RIF. The women underwent immunization with lymphocytes of their respective partners from November 2017 to August 2019. Fifty-five patients (43%) had live births. Stratified by indication (RM, RIF, combined), live birth rates in the RM and the combined group were significantly higher than that in the RIF group (53%, 59% and 33%, respectively, p = 0.02). The difference was especially noticeable during the first 90 days after immunization (conception rate leading to live births: 31%, 23% and 8% for RM, the combined group and RIF, respectively; p = 0.005), while there was no difference between groups during the later follow-up. LIT was associated with high live birth rates, especially in women with recurrent miscarriage. In view of the limited data from randomized studies, LIT cannot be recommended as routine therapy. However, it may be considered in individual cases.

Does surgery improve live birth rates in patients with recurrent miscarriage caused by uterine anomalies?

2014 ◽  
Vol 35 (2) ◽  
pp. 155-158 ◽  
Author(s):  
M. Sugiura-Ogasawara ◽  
B. L. Lin ◽  
K. Aoki ◽  
T. Maruyama ◽  
M. Nakatsuka ◽  
...  
Keyword(s):  
Live Birth ◽  
Recurrent Miscarriage ◽  
Birth Rates ◽  
Live Birth Rates ◽  
Uterine Anomalies

Preimplantation Genetic Testing for Aneuploidy: Current Perspectives

2021 ◽  
Author(s):  
Ariadne L'Heveder ◽  
Benjamin P. Jones ◽  
Roy Naja ◽  
Paul Serhal ◽  
Jara Ben Nagi
Keyword(s):  
Genetic Testing ◽  
Live Birth ◽  
Culture Media ◽  
Recurrent Miscarriage ◽  
Birth Rates ◽  
Preimplantation Genetic Testing ◽  
Live Birth Rates ◽  
Future Direction ◽  
Cost Implications ◽  
The Cost

AbstractDespite improvements in assisted reproduction techniques (ARTs), live birth rates remain suboptimal, particularly in women with advanced maternal age (AMA). The leading cause of poor reproductive outcomes demonstrated in women with AMA, as well as women with recurrent miscarriage and repetitive implantation failure, is thought to be due to high rates of embryonic aneuploidy. Preimplantation genetic testing for aneuploidies (PGT-A) aims to select an euploid embryo for transfer and therefore improve ART outcomes. Early PGT-A studies using fluorescent in situ hybridization on mainly cleavage-stage biopsies failed to show improved delivery rates and, in certain cases, were even found to be harmful. However, the development of comprehensive chromosome screening, as well as improvements in culture media and vitrification techniques, has resulted in an emerging body of evidence in favor of PGT-A, demonstrating higher implantation, pregnancy, and live birth rates. While there are concerns regarding the potential harm of invasive biopsy and the cost implications of PGT-A, the introduction of noninvasive techniques and the development of new high-throughput methods which lower costs are tackling these issues. This review aims to assess the evidence for PGT-A, address possible concerns regarding PGT-A, and also explore the future direction of this technology.

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