Association analysis of two synapse-related gene mutations with autism spectrum disorder in a Chinese population

2018 ◽  
Vol 53 ◽  
pp. 67-72
Author(s):  
Fang Hou ◽  
Li Li ◽  
Jianhua Gong ◽  
Yanlin Chen ◽  
Jia Wang ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Association Analysis ◽  
Chinese Population ◽  
Gene Mutations ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Related Gene

Resequencing and association analysis of GAP43 with autism spectrum disorder and schizophrenia in a Japanese population

2021 ◽  
Vol 82 ◽  
pp. 101729
Author(s):  
Reza K. Arta ◽  
Yuichiro Watanabe ◽  
Emiko Inoue ◽  
Yoshihiro Nawa ◽  
Ryo Morikawa ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Association Analysis ◽  
Japanese Population ◽  
Autism Spectrum ◽  
Spectrum Disorder

scholarly journals Resequencing and association analysis ofOXTRwith autism spectrum disorder in a Japanese population

2014 ◽  
Vol 69 (3) ◽  
pp. 131-135 ◽  
Author(s):  
Jun Egawa ◽  
Yuichiro Watanabe ◽  
Masako Shibuya ◽  
Taro Endo ◽  
Atsunori Sugimoto ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Association Analysis ◽  
Japanese Population ◽  
Autism Spectrum ◽  
Spectrum Disorder

scholarly journals Association Between HLA-B Polymorphisms and Autism Spectrum Disorder in Chinese Population

2020 ◽  
Vol 30 (1) ◽  
Author(s):  
Guojun Kang ◽  
Qi Kang ◽  
Xiaojing Zhu ◽  
Rixin Li ◽  
Shangchao Zhang ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Chinese Population ◽  
Autism Spectrum ◽  
Spectrum Disorder

Elucidation of Abnormal Extracellular Regulated Kinase (ERK) Signaling and Associations with Syndromic and Non-syndromic Autism

2020 ◽  
Vol 21 ◽  
Author(s):  
Aarti Tiwari ◽  
Saloni Rahi ◽  
Sidharth Mehan
Keyword(s):  
Autism Spectrum Disorder ◽  
Single Gene ◽  
Neurodevelopmental Disorder ◽  
Gene Mutations ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Erk Signaling ◽  
Erk Pathway ◽  
Signaling Mechanism ◽  
Syndromic Autism

Abstract: Autism is a highly inherited and extremely complex disorder in which results from various cases indicate chro-mosome anomalies, unusual single-gene mutations, and multiplicative effects of particular gene variants, characterized pri-marily by impaired speech and social interaction and restricted behavior. The precise etiology of Autism Spectrum Disorder (ASD) is currently unclear. The extracellular signal-regulated kinase (ERK) signaling mechanism affects neurogenesis and neuronal plasticity during the development of the central nervous mechanism. In this regard, the pathway of ERK has re-cently gained significant interest in the pathogenesis of ASD. The mutation occurs in a few ERK components. Besides, the ERK pathway dysfunction lies in the upstream of modified translation and contributes to synapse pathology in syndromic types of autism. In this review, we highlight the ERK pathway as a target for neurodevelopmental disorder autism. In addi-tion, we summarize the regulation of the ERK pathway with ERK inhibitors in neurological disorders. In conclusion, a better understanding of the ERK signaling pathway provides a range of therapeutic options for autism spectrum disorder

Association analysis of the GABRB3 promoter variant and susceptibility to autism spectrum disorder

Basal Ganglia ◽  
2018 ◽  
Vol 11 ◽  
pp. 4-7 ◽  
Author(s):  
Rezvan Noroozi ◽  
Mohammad Taheri ◽  
Abolfazl Movafagh ◽  
Soudeh Ghafouri-Fard ◽  
Arezou Sayad ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Association Analysis ◽  
Autism Spectrum ◽  
Spectrum Disorder
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