Facial emotion processing and social adaptation in adults with and without autism spectrum disorder

2010 ◽  
Vol 4 (4) ◽  
pp. 755-762 ◽  
Author(s):  
Domingo García-Villamisar ◽  
Johannes Rojahn ◽  
Rebecca H. Zaja ◽  
Marina Jodra
Keyword(s):  
Autism Spectrum Disorder ◽  
Emotion Processing ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Social Adaptation ◽  
Facial Emotion ◽  
Facial Emotion Processing

scholarly journals Serotonin differentially modulates the temporal dynamics of the limbic response to facial emotions in male adults with and without autism spectrum disorder (ASD): a randomised placebo-controlled single-dose crossover trial

2020 ◽  
Vol 45 (13) ◽  
pp. 2248-2256
Author(s):  
Nichol M. L. Wong ◽  
James L. Findon ◽  
Robert H. Wichers ◽  
Vincent Giampietro ◽  
Vladimira Stoencheva ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Temporal Dynamics ◽  
Emotion Processing ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Facial Emotion ◽  
Brain Dynamics ◽  
Facial Emotion Processing ◽  
Adults With Asd ◽  
Limbic Regions

Abstract Emotion processing—including signals from facial expressions—is often altered in individuals with autism spectrum disorder (ASD). The biological basis of this is poorly understood but may include neurochemically mediated differences in the responsivity of key ‘limbic’ regions (including amygdala, ventromedial prefrontal cortex (vmPFC) and nucleus accumbens (NAc)). Emerging evidence also suggests that ASD may be a disorder of brain temporal dynamics. Moreover, serotonin (5-HT) has been shown to be a key regulator of both facial-emotion processing and brain dynamics, and 5-HT abnormalities have been consistently implicated in ASD. To date, however, no one has examined how 5-HT influences the dynamics of facial-emotion processing in ASD. Therefore, we compared the influence of 5-HT on the responsivity of brain dynamics during facial-emotion processing in individuals with and without ASD. Participants completed a facial-emotion processing fMRI task at least 8 days apart using a randomised double-blind crossover design. At each visit they received either a single 20-mg oral dose of the selective serotonin reuptake inhibitor (SSRI) citalopram or placebo. We found that citalopram (which increases levels of 5-HT) caused sustained activation in key limbic regions during processing of negative facial emotions in adults with ASD—but not in neurotypical adults. The neurotypical adults’ limbic response reverted more rapidly to baseline following a 5-HT-challenge. Our results suggest that serotonergic homoeostatic control of the temporal dynamics in limbic regions is altered in adults with ASD, and provide a fresh perspective on the biology of ASD.

scholarly journals Autism in Fragile X Syndrome; A Functional MRI Study of Facial Emotion-Processing

Genes ◽  
2019 ◽  
Vol 10 (12) ◽  
pp. 1052
Author(s):  
Andrew G. McKechanie ◽  
Sonya Campbell ◽  
Sarah E. A. Eley ◽  
Andrew C. Stanfield
Keyword(s):  
Autism Spectrum Disorder ◽  
Fragile X Syndrome ◽  
Fragile X ◽  
Emotion Processing ◽  
Autistic Traits ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Facial Emotion ◽  
Facial Emotion Processing ◽  
The Impact

Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability and autism spectrum disorder, and among those with fragile X syndrome, approximately 1/3rd meet a threshold for an autism spectrum disorder (ASD) diagnosis. Previous functional imaging studies of fragile X syndrome have typically focused on those with fragile X syndrome compared to either neurotypical or autism spectrum disorder control groups. Further, the majority of previous studies have tended to focus on those who are more intellectually able than is typical for fragile X syndrome. In this study, we examine the impact of autistic traits in individuals with fragile X syndrome on a paradigm looking at facial emotion processing. The study included 17 individuals with fragile X syndrome, of whom 10 met criteria for autism as measured by the Autism Diagnostic Observation Schedule (ADOS). Prior to the scan, participants rehearsed on a mock scanner to help acclimatize to the scanner environment and thus allow more severely affected individuals to participate. The task examined the blood-oxygen-level-dependent (BOLD) response to fearful and neutral faces taken from the Ekman faces series. Individuals in the autism group had a region of significantly reduced activity centered on the left superior temporal gyrus, compared to those with FXS alone, in response to the fearful faces. We suggest that autism in individuals with fragile X syndrome is associated with similar changes in the neurobiology of facial emotion processing as seen in idiopathic autism.

scholarly journals Inflexibility in Autism Spectrum Disorder: Need for certainty and atypical emotion processing share the blame

2019 ◽  
Vol 136 ◽  
pp. 103599 ◽  
Author(s):  
Marianne Latinus ◽  
Helen Cléry ◽  
Frédéric Andersson ◽  
Frédérique Bonnet-Brilhault ◽  
Pierre Fonlupt ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Emotion Processing ◽  
Autism Spectrum ◽  
Spectrum Disorder

Facial emotion recognition in paranoid schizophrenia and autism spectrum disorder

2014 ◽  
Vol 159 (2-3) ◽  
pp. 509-514 ◽  
Author(s):  
Michael Sachse ◽  
Sabine Schlitt ◽  
Daniela Hainz ◽  
Angela Ciaramidaro ◽  
Henrik Walter ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Emotion Recognition ◽  
Paranoid Schizophrenia ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Facial Emotion Recognition ◽  
Facial Emotion

scholarly journals Electrophysiology of Inhibitory Control in the Context of Emotion Processing in Children With Autism Spectrum Disorder

2019 ◽  
Vol 13 ◽  
Author(s):  
Justine R. Magnuson ◽  
Nicholas A. Peatfield ◽  
Shaun D. Fickling ◽  
Adonay S. Nunes ◽  
Greg Christie ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Inhibitory Control ◽  
Emotion Processing ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder
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