Azithromycin differentially affects the IL-13-induced expression profile in human bronchial epithelial cells

2016 ◽  
Vol 39 ◽  
pp. 14-20 ◽  
Author(s):  
Tinne C.J. Mertens ◽  
Pieter S. Hiemstra ◽  
Christian Taube
Keyword(s):  
Epithelial Cells ◽  
Expression Profile ◽  
Bronchial Epithelial Cells ◽  
Human Bronchial Epithelial Cells ◽  
Induced Expression ◽  
Bronchial Epithelial

scholarly journals Activation of MAPKs in human bronchial epithelial cells exposed to metals

1998 ◽  
Vol 275 (3) ◽  
pp. L551-L558 ◽  
Author(s):  
James M. Samet ◽  
Lee M. Graves ◽  
Jacqueline Quay ◽  
Lisa A. Dailey ◽  
Robert B. Devlin ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Bronchial Epithelial Cells ◽  
Human Bronchial Epithelial Cells ◽  
Subsequent Increase ◽  
Induced Expression ◽  
Bronchial Epithelial ◽  
Mitogen Activated Protein ◽  
Metallic Compounds ◽  
Factor Α

We have previously shown that in vitro exposure to metallic compounds enhances expression of interleukin (IL)-6, IL-8, and tumor necrosis factor-α in human bronchial epithelial cells. To characterize signaling pathways involved in metal-induced expression of inflammatory mediators and to identify metals that activate them, we studied the effects of As, Cr, Cu, Fe, Ni, V, and Zn on the mitogen-activated protein kinases (MAPK) extracellular receptor kinase (ERK), c-Jun NH2-terminal kinase (JNK), and P38 in BEAS cells. Noncytotoxic concentrations of As, V, and Zn induced a rapid phosphorylation of MAPK in BEAS cells. Activity assays confirmed marked activation of ERK, JNK, and P38 in BEAS cells exposed to As, V, and Zn. Cr and Cu exposure resulted in a relatively small activation of MAPK, whereas Fe and Ni did not activate MAPK under these conditions. Similarly, the transcription factors c-Jun and ATF-2, substrates of JNK and P38, respectively, were markedly phosphorylated in BEAS cells treated with As, Cr, Cu, V, and Zn. The same acute exposure to As, V, or Zn that activated MAPK was sufficient to induce a subsequent increase in IL-8 protein expression in BEAS cells. These data suggest that MAPK may mediate metal-induced expression of inflammatory proteins in human bronchial epithelial cells.

GENE EXPRESSION PROFILE BY RNAi-MEDIATED SUPPRESSION OF S100A2 IN HUMAN BRONCHIAL EPITHELIAL CELLS

Toukeibu Gan ◽  
2005 ◽  
Vol 31 (4) ◽  
pp. 481-486
Author(s):  
Nobuhiko ORIDATE ◽  
Takatsugu MIZUMACHI ◽  
Fumiyuki SUZUKI ◽  
Akihiro HOMMA ◽  
Yasushi FURUTA ◽  
...  
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Bronchial Epithelial Cells ◽  
Human Bronchial Epithelial Cells ◽  
Bronchial Epithelial

scholarly journals Gene Expression Profile and Toxic Effects in Human Bronchial Epithelial Cells Exposed to Zearalenone

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e96404 ◽  
Author(s):  
Mei Yu So ◽  
ZhiPeng Tian ◽  
Yong Shian Phoon ◽  
Sha Sha ◽  
Michael N. Antoniou ◽  
...  
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Bronchial Epithelial Cells ◽  
Toxic Effects ◽  
Human Bronchial Epithelial Cells ◽  
Bronchial Epithelial
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