scholarly journals The attenuation of dysfunctional emotional processing with stimulant medication: An fMRI study of adolescents with ADHD

2011 ◽  
Vol 193 (3) ◽  
pp. 151-160 ◽  
Author(s):  
Jonathan Posner ◽  
Tiago V. Maia ◽  
Damien Fair ◽  
Bradley S. Peterson ◽  
Edmund J. Sonuga-Barke ◽  
...  
Author(s):  
T. Pattyn ◽  
L. Schmaal ◽  
F. Van Den Eede ◽  
L. Cassiers ◽  
BW Penninx ◽  
...  

2007 ◽  
Vol 13 (11) ◽  
pp. 1011-1020 ◽  
Author(s):  
R Norbury ◽  
C E Mackay ◽  
P J Cowen ◽  
G M Goodwin ◽  
C J Harmer

NeuroImage ◽  
2000 ◽  
Vol 11 (5) ◽  
pp. S377
Author(s):  
Michelle L. Keightley ◽  
Cheryl L. Grady ◽  
Simon J. Graham ◽  
Gordon Winocur ◽  
Helen S. Mayberg

2020 ◽  
Vol 17 (3) ◽  
pp. 225-236 ◽  
Author(s):  
Rosa M. Molina-Ruiz ◽  
T. García-Saiz ◽  
Jeffrey C.L. Looi ◽  
E. Via Virgili ◽  
M. Rincón Zamorano ◽  
...  

Objective Emotional processing dysfunction evident in eating disorders (ED) such as anorexia nervosa (AN) and bulimia nervosa (BN), is considered relevant to the development and maintenance of these disorders. The purpose of the current functional magnetic resonance imaging (fMRI) study was to pilot a comparison of the activity of the fronto-limbic and fronto-striatal brain areas during an emotion processing task in persons with ED.Methods 24 women patients with ED were scanned, while showing emotionally stimulating (pleasant, unpleasant) and neutral images from the International Affective Picture System (IAPS).Results During the pleasant condition, significant differences in Dorsolateral Prefrontal Cortex (DLPFC) activations were found with AN participants presenting greater activation compared to BN and ED comorbid groups (EDc) and healthy controls also showing greater activation of this brain area compared to BN and EDc. Left putamen was less activated in EDc compared to both controls (C) and AN. During the unpleasant condition, AN participants showed hyperactivation of the Orbito-frontal Cortex (OFC) when compared to EDc.Conclusion This study highlights the potential functional relevance of brain areas that have been associated with self-control. These findings should help advance understanding the neural substrate of ED, though they should be considered as preliminary and be cautiously interpreted.


2016 ◽  
Vol 30 (3) ◽  
pp. 114-123 ◽  
Author(s):  
Tokiko Harada ◽  
Akiko Hayashi ◽  
Norihiro Sadato ◽  
Tetsuya Iidaka

Abstract. Facial expressions play a significant role in displaying feelings. A person’s facial expression automatically induces a similar emotional feeling in an observer; this phenomenon is known as emotional contagion. However, little is known about the neural mechanisms underlying such emotional responses. We conducted an event-related functional magnetic resonance imaging (fMRI) study to examine the neural substrates involved in automatic responses and emotional feelings induced by movies of another person’s happy and sad facial expressions. The fMRI data revealed observing happiness (vs. sadness) evoked activity in the left anterior cingulate gyrus, which is known to be responsible for positive emotional processing and fear inhibition. Conversely, observing sadness (vs. happiness) increased activity in the right superior temporal sulcus and bilateral inferior parietal lobes, which have been reported to be involved in negative emotional processing and the representation of facial movements. In addition, both expressions evoked activity in the right inferior frontal gyrus. These patterns of activity suggest that the observation of dynamic facial expressions automatically elicited dissociable and partially overlapping responses for happy and sad emotions.


2020 ◽  
Vol 32 (6) ◽  
pp. 1117-1129
Author(s):  
Eva Loos ◽  
Nathalie Schicktanz ◽  
Matthias Fastenrath ◽  
David Coynel ◽  
Annette Milnik ◽  
...  

The amygdala is critically involved in emotional processing, including fear responses, and shows hyperactivity in anxiety disorders. Previous research in healthy participants has indicated that amygdala activity is down-regulated by cognitively demanding tasks that engage the PFC. It is unknown, however, if such an acute down-regulation of amygdala activity might correlate with reduced fear in anxious participants. In an fMRI study of 43 participants (11 men) with fear of snakes, we found reduced amygdala activity when visual stimuli were processed under high cognitive load, irrespective of whether the stimuli were of neutral or phobic content. Furthermore, dynamic causal modeling revealed that this general reduction in amygdala activity was partially mediated by a load-dependent increase in dorsolateral PFC activity. Importantly, high cognitive load also resulted in an acute decrease in perceived phobic fear while viewing the fearful stimuli. In conclusion, our data indicate that a cognitively demanding task results in a top–down regulation of amygdala activity and an acute reduction of fear in phobic participants. These findings may inspire the development of novel psychological intervention approaches aimed at reducing fear in anxiety disorders.


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