scholarly journals Late-life Depression: Evidence-based Treatment and Promising New Directions for Research and Clinical Practice

2011 ◽  
Vol 34 (2) ◽  
pp. 335-355 ◽  
Author(s):  
Carmen Andreescu ◽  
Charles F. Reynolds
Keyword(s):  
Clinical Practice ◽  
Late Life ◽  
Evidence Based ◽  
Late Life Depression ◽  
Evidence Based Treatment ◽  
New Directions

Refining Evidence-Based Treatments for Late-Life Depression

GeroPsych ◽  
2015 ◽  
Vol 28 (2) ◽  
pp. 67-76
Author(s):  
Grace C. Niu ◽  
Patricia A. Arean
Keyword(s):  
Older Adults ◽  
Mental Illness ◽  
Brain Plasticity ◽  
Late Life ◽  
Aging Population ◽  
The United States ◽  
Future Research ◽  
Evidence Based ◽  
Late Life Depression ◽  
Evidence Based Treatments

The recent increase in the aging population, specifically in the United States, has raised concerns regarding treatment for mental illness among older adults. Late-life depression (LLD) is a complex condition that has become widespread among the aging population. Despite the availability of behavioral interventions and psychotherapies, few depressed older adults actually receive treatment. In this paper we review the research on refining treatments for LLD. We first identify evidence-based treatments (EBTs) for LLD and the problems associated with efficacy and dissemination, then review approaches to conceptualizing mental illness, specifically concepts related to brain plasticity and the Research Domain Criteria (RDoc). Finally, we introduce ENGAGE as a streamlined treatment for LLD and discuss implications for future research.

scholarly journals The Complexity Approach to Phonological Treatment: How to Select Treatment Targets

2018 ◽  
Vol 49 (3) ◽  
pp. 463-481 ◽  
Author(s):  
Holly L. Storkel
Keyword(s):  
Clinical Practice ◽  
Preschool Children ◽  
Treatment Options ◽  
Target Selection ◽  
Evidence Based ◽  
Treatment Target ◽  
Evidence Based Treatment ◽  
Phonological Disorders ◽  
Link Type ◽  
Phonological Treatment

Purpose There are a number of evidence-based treatments for preschool children with phonological disorders (Baker & McLeod, 2011). However, a recent survey by Brumbaugh and Smit (2013) suggests that speech-language pathologists are not equally familiar with all evidence-based treatment alternatives, particularly the complexity approach. The goal of this clinical tutorial is to provide coaching on the implementation of the complexity approach in clinical practice, focusing on treatment target selection. Method Evidence related to selecting targets for treatment based on characteristics of the targets (i.e., developmental norms, implicational universals) and characteristics of children's knowledge of the targets (i.e., accuracy, stimulability) is reviewed. Free resources are provided to aid clinicians in assessing accuracy and stimulability of singletons and clusters. Use of treatment target selection and generalization prediction worksheets is illustrated with 3 preschool children. Results Clinicians can integrate multiple pieces of information to select complex targets and successfully apply the complexity approach to their own clinical practice. Conclusion Incorporating the complexity approach into clinical practice will expand the range of evidence-based treatment options that clinicians can use when treating preschool children with phonological disorders. Supplemental Material S1 https://doi.org/10.23641/asha.6007562 KU ScholarWorks Supplemental Material http://hdl.handle.net/1808/24767

scholarly journals Lactoferrin: Cytokine Modulation and Application in Clinical Practice

2021 ◽  
Vol 10 (23) ◽  
pp. 5482
Author(s):  
Santiago Presti ◽  
Sara Manti ◽  
Giuseppe Fabio Parisi ◽  
Maria Papale ◽  
Ignazio Alberto Barbagallo ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Respiratory Diseases ◽  
In Vivo Studies ◽  
Evidence Based ◽  
Evidence Based Treatment ◽  
Cytokine Modulation ◽  
Safe Option ◽  
Anti Oxidant

Multiple properties of lactoferrin have been reported in the literature so far. Decades of in vitro and in vivo studies have demonstrated the important antimicrobial, anti-inflammatory, anti-oxidant, and immunomodulating properties. It suggests the use of lactoferrin as an effective and safe option for the treatment of several common disorders. Herein, we show the applications of lactoferrin in clinical practice, highlighting its evidence-based capacities for the treatment of heterogeneous disorders, such as allergic, gastrointestinal, and respiratory diseases, and hematologic, oncologic, gynecologic, dermatologic, and dental disorders. Moreover, the widespread use of lactoferrin in neonatology is summarized here. As a result of its antiviral properties, lactoferrin has also been proposed as a valid option for the treatment for COVID-19 patients. Here, the uses of lactoferrin in clinical practice as a new, safe, and evidence-based treatment for many types of disorders are summarized.

The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia

Blood ◽  
2011 ◽  
Vol 117 (16) ◽  
pp. 4190-4207 ◽  
Author(s):  
Cindy Neunert ◽  
Wendy Lim ◽  
Mark Crowther ◽  
Alan Cohen ◽  
Lawrence Solberg ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Practice Guideline ◽  
Salvage Therapy ◽  
Immune Thrombocytopenia ◽  
Evidence Based ◽  
Front Line ◽  
First Line ◽  
Evidence Based Treatment ◽  
Line Therapy ◽  
American Society

AbstractImmune thrombocytopenia (ITP) is commonly encountered in clinical practice. In 1996 the American Society of Hematology published a landmark guidance paper designed to assist clinicians in the management of this disorder. Since 1996 there have been numerous advances in the management of both adult and pediatric ITP. These changes mandated an update in the guidelines. This guideline uses a rigorous, evidence-based approach to the location, interpretation, and presentation of the available evidence. We have endeavored to identify, abstract, and present all available methodologically rigorous data informing the treatment of ITP. We provide evidence-based treatment recommendations using the GRADE system in those areas in which such evidence exists. We do not provide evidence in those areas in which evidence is lacking, or is of lower quality—interested readers are referred to a number of recent, consensus-based recommendations for expert opinion in these clinical areas. Our review identified the need for additional studies in many key areas of the therapy of ITP such as comparative studies of “front-line” therapy for ITP, the management of serious bleeding in patients with ITP, and studies that will provide guidance about which therapy should be used as salvage therapy for patients after failure of a first-line intervention.

scholarly journals What are evidence-based treatment recommendations?

2011 ◽  
Vol 20 (1) ◽  
pp. 29-31 ◽  
Author(s):  
C. Barbui ◽  
A. Cipriani
Keyword(s):  
Clinical Practice ◽  
Treatment Recommendations ◽  
Evidence Based ◽  
Primary Research ◽  
Everyday Clinical Practice ◽  
Evidence Based Treatment ◽  
Assessment Development ◽  
New Methodologies ◽  
Grade Methodology

In recent years new methodologies for developing treatment recommendations that give consideration to evidence, values, preferences and feasibility issues have been developed. One of the most well-developed approaches is theGrading of Recommendations Assessment, Development and Evaluation(GRADE) methodology. This article briefly presents how this methodology may be employed to develop treatment recommendations that might constitute a permanent infrastructure between primary research and everyday clinical practice.

The Prevalence of Late-Lifedepression and Physicians’ Attitude Toward it in Primary Care Settings of China

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
S. Chen
Keyword(s):  
Primary Care ◽  
Clinical Practice ◽  
Older People ◽  
Primary Care Physicians ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Late Life ◽  
Well Being ◽  
Late Life Depression ◽  
Primary Care Settings

Late-life depression is associated with physical and psychological comorbidity, functional and cognitive impairment, and increased mortality due to suicide and other causes. However, studies in the west show that the identification of depression in older people is problematic and consequently the illness is underdiagnosed and undertreated. We investigated the prevalence of late-life depression and physicians’ attitude toward it in primary care settings of China.The survey was performed in urban primary care settings of Hangzhou, China. 1000 patients aged ≥ 55 years and 300 primary care physicians were recruited, of which 689 patients and 247 physicians provided complete data. The Geriatric Depression Scale (GDS-30) was used for investigating the prevalence of late-life depression in patients, and the Depression Attitude Questionnaire (DAQ) for investigating physicians’ attitudes and knowledge about depression.Of the 689 patients, 23.4% (n=161) scored ≥ 11 on the GDS-30, including 3% (n=21) who scored ≥ 21. Among the physicians, 72% (n=178) endorsed that “Becoming depressed is a natural part of being old”, and 70% (n=173) of them thought “Working with depressed patients is heavy going”; in their clinical practice. Only 6.6% of physicians prescribed anti-depressants.Primary care physicians in China are ill prepared to diagnose and treat depression in older adults, which presents at high rates in primary care clinics. How to improve their attitudes and clinical practice is crucial to the well-being of older people in China.

scholarly journals Neurobiology Informed, Mobile Technology Augmented Interventions for Late-Life Depression and Suicidality

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 622-622
Author(s):  
George Alexopoulos
Keyword(s):  
Mobile Technology ◽  
Behavioral Activation ◽  
Mobile Apps ◽  
Late Life ◽  
Evidence Based ◽  
Behavioral Strategies ◽  
Late Life Depression ◽  
Community Based ◽  
Problem Solving Therapy ◽  
Behavioral Pathology

Abstract Depression is a major risk factor of suicide in late life. Evidence based psychotherapies for late-life depression are underutilized, mainly because of their complexity. In response, we created “Engage”, an innovative streamlined psychotherapy that relies on neurobiology findings to identify core behavioral pathology of late-life depression and targets it with simple cognitive-behavioral strategies of known efficacy, co-designed with community therapists so that its interventions can be mastered my community based clinicians. We demonstrated that “Engage” is non-inferior to the evidence based Problem Solving Therapy and documented that behavioral activation precedes improvement of depression. We have also shown that activities with important others have the strongest behavioral activation value. “Engage” served as a model for three novel, mobile technology augmented psychotherapies that address the clinical and psychosocial context of distinct populations of depressed older adults. Our interventions and mobile apps provide interventions for emotion regulation as a way of reducing suicidality.

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