D4/163 – Hepatocyte growth factor attenuates functional and pathological abnormalities in newborn mouse model of bronchopulmonary dysplasia

2006 ◽  
Vol 7 ◽  
pp. S299-S300
Author(s):  
Y. Ohki ◽  
H. Mayuzumi ◽  
K. Tokuyama ◽  
Y. Yoshizawa ◽  
H. Arakawa ◽  
...  
Keyword(s):  
Growth Factor ◽  
Mouse Model ◽  
Hepatocyte Growth Factor ◽  
Bronchopulmonary Dysplasia ◽  
Newborn Mouse ◽  
Hepatocyte Growth

Hepatocyte growth factor overexpression ameliorates liver inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis

2011 ◽  
Vol 6 (3) ◽  
pp. 620-630 ◽  
Author(s):  
Hiroki Tojima ◽  
Satoru Kakizaki ◽  
Takashi Kosone ◽  
Norio Horiguchi ◽  
Yuichi Yamazaki ◽  
...  
Keyword(s):  
Growth Factor ◽  
Mouse Model ◽  
Hepatocyte Growth Factor ◽  
Nonalcoholic Steatohepatitis ◽  
Liver Inflammation ◽  
Hepatocyte Growth

scholarly journals Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease.

1998 ◽  
Vol 101 (9) ◽  
pp. 1827-1834 ◽  
Author(s):  
S Mizuno ◽  
T Kurosawa ◽  
K Matsumoto ◽  
Y Mizuno-Horikawa ◽  
M Okamoto ◽  
...  
Keyword(s):  
Growth Factor ◽  
Mouse Model ◽  
Renal Disease ◽  
Hepatocyte Growth Factor ◽  
Renal Fibrosis ◽  
Chronic Renal Disease ◽  
Hepatocyte Growth

scholarly journals Molecular Therapy Targeting Sonic Hedgehog and Hepatocyte Growth Factor Signaling in a Mouse Model of Medulloblastoma

2010 ◽  
Vol 9 (9) ◽  
pp. 2627-2636 ◽  
Author(s):  
Valerie Coon ◽  
Tamara Laukert ◽  
Carolyn A. Pedone ◽  
John Laterra ◽  
K. Jin Kim ◽  
...  
Keyword(s):  
Growth Factor ◽  
Mouse Model ◽  
Hepatocyte Growth Factor ◽  
Sonic Hedgehog ◽  
Molecular Therapy ◽  
Growth Factor Signaling ◽  
Hepatocyte Growth

scholarly journals ID: 1041 Effectiveness of human adipose-derived stem cell therapy pretreated with hepatocyte growth factor in liver fibrosis mouse model

2017 ◽  
Vol 4 (S) ◽  
pp. 119
Author(s):  
Ngoc Hong Vo ◽  
Trinh Van Le ◽  
Nam Hai Nguyen ◽  
Yen K.T. Nguyen ◽  
Thanh Minh Dang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Liver Fibrosis ◽  
Mouse Model ◽  
Hepatocyte Growth Factor ◽  
Therapeutic Effect ◽  
Smooth Muscle Actin ◽  
Alpha Smooth Muscle Actin ◽  
Promoting Effect ◽  
Significant Difference ◽  
Hepatocyte Growth

Background: Adipose-derived stem cells (ADSCs) have the potential therapeutic impact on the liver fibrosis. Hepatocyte growth factor (HGF) is pivotal for damage repair with its anti-apoptotic, anti-fibrotic and cell migration-promoting effect. In this study, the therapy with HGF-pretreated hADSCs was expected to enhance the therapeutic effect in the amelioration of liver fibrosis compared with untreated hADSCs.   Method: HGF-hADSCs were prepared by culturing hADSCs for seven days in the medium added HGF. HGF-hADSCs transplantation was performed to investigate the therapeutic effect of these cells on carbon tetrachloride (CCl4)-induced liver fibrosis in a mouse model.  Results: After seven days and fourteen days of cell transfusion, HGF-hADSCs ameliorated the liver fibrosis. The results showed the attenuation of the liver injury (ALT level), the down-regulation of procollagen-1 (7 days, 3-fold; 14 days, 6.7-fold) and alpha -smooth muscle actin (alpha-SMA) expression (7 days, 10-fold; 14 days, 2-fold), and the histological improvement. Notably, there was the significant difference in the procollagen-1 between HGF-hADSCs and untreated hADSCs groups. Thus, the therapy with HGF-hADSCs was more efficient in the liver fibrosis treatment compared with untreated hADSCs.  Conclusion: HGF pretreated hADSCs have a potential therapy in the treatment of liver fibrosis

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