A Pilot 11C-Choline PET/CT Imaging Study Investigating the Ability to Detect Occult Metastatic Osseous Disease in Newly Diagnosed High-Risk Prostate Adenocarcinoma

2013 ◽  
Vol 3 (2) ◽  
pp. S27 ◽  
Author(s):  
D.N. Ayala-Peacock ◽  
N. Onyeuku ◽  
A.J. Thomas ◽  
P. Garg ◽  
A.W. Blackstock
Keyword(s):  
High Risk ◽  
Imaging Study ◽  
Prostate Adenocarcinoma ◽  
Ct Imaging ◽  
Newly Diagnosed ◽  
Choline Pet ◽  
Pet Ct

18F-F-Choline PET/CT in staging of newly diagnosed high-risk prostate cancer

2021 ◽  
Vol 45 (4) ◽  
pp. 223
Author(s):  
Y. Benameur ◽  
O. Ait Sahel ◽  
S. Nabih Oueriagli ◽  
J. El Bekkali ◽  
A. Doudouh
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Newly Diagnosed ◽  
Choline Pet ◽  
High Risk Prostate Cancer ◽  
Pet Ct ◽  
Risk Prostate Cancer

scholarly journals The Role of [18F]Fluciclovine PET/CT in the Characterization of High-Risk Primary Prostate Cancer: Comparison with [11C]Choline PET/CT and Histopathological Analysis

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1575
Author(s):  
Lucia Zanoni ◽  
Riccardo Mei ◽  
Lorenzo Bianchi ◽  
Francesca Giunchi ◽  
Lorenzo Maltoni ◽  
...  
Keyword(s):  
Bone Marrow ◽  
High Risk ◽  
Malignant Lesion ◽  
Lesion Detection ◽  
Histopathological Analysis ◽  
Choline Pet ◽  
Primary Prostate Cancer ◽  
Pet Ct

The primary aim of the study was to evaluate the role of [18F]Fluciclovine PET/CT in the characterization of intra-prostatic lesions in high-risk primary PCa patients eligible for radical prostatectomy, in comparison with conventional [11C]Choline PET/CT and validated by prostatectomy pathologic examination. Secondary aims were to determine the performance of PET semi-quantitative parameters (SUVmax; target-to-background ratios [TBRs], using abdominal aorta, bone marrow and liver as backgrounds) for malignant lesion detection (and best cut-off values) and to search predictive factors of malignancy. A six sextants prostate template was created and used by PET readers and pathologists for data comparison and validation. PET visual and semi-quantitative analyses were performed: for instance, patient-based, blinded to histopathology; subsequently lesion-based, un-blinded, according to the pathology reference template. Among 19 patients included (mean age 63 years, 89% high and 11% very-high-risk, mean PSA 9.15 ng/mL), 45 malignant and 31 benign lesions were found and 19 healthy areas were selected (n = 95). For both tracers, the location of the “blinded” prostate SUVmax matched with the lobe of the lesion with the highest pGS in 17/19 cases (89%). There was direct correlation between [18F]Fluciclovine uptake values and pISUP. Overall, lesion-based (n = 95), the performance of PET semiquantitative parameters, with either [18F]Fluciclovine or [11C]Choline, in detecting either malignant/ISUP2-5/ISUP4-5 PCa lesions, was moderate and similar (AUCs ≥ 0.70) but still inadequate (AUCs ≤ 0.81) as a standalone staging procedure. A [18F]Fluciclovine TBR-L3 ≥ 1.5 would depict a clinical significant lesion with a sensitivity and specificity of 85% and 68% respectively; whereas a SUVmax cut-off value of 4 would be able to identify a ISUP 4-5 lesion in all cases (sensitivity 100%), although with low specificity (52%). TBRs (especially with threshold significantly higher than aorta and slightly higher than bone marrow), may be complementary to implement malignancy targeting.

scholarly journals Biodistribution and Dosimetry of18F-Meta-Fluorobenzylguanidine: A First-in-Human PET/CT Imaging Study of Patients with Neuroendocrine Malignancies

2017 ◽  
Vol 59 (1) ◽  
pp. 147-153 ◽  
Author(s):  
Neeta Pandit-Taskar ◽  
Pat Zanzonico ◽  
Kevin D. Staton ◽  
Jorge A. Carrasquillo ◽  
Diane Reidy-Lagunes ◽  
...  
Keyword(s):  
Imaging Study ◽  
Ct Imaging ◽  
Pet Ct

scholarly journals Preoperative PET/CT does not accurately detect extrauterine disease in patients with newly diagnosed high‐risk endometrial cancer: A prospective study

Cancer ◽  
2019 ◽  
Vol 125 (19) ◽  
pp. 3347-3353 ◽  
Author(s):  
Katherine I. Stewart ◽  
Beth Chasen ◽  
William Erwin ◽  
Nicole Fleming ◽  
Shannon N. Westin ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
High Risk ◽  
Prospective Study ◽  
Newly Diagnosed ◽  
Pet Ct ◽  
A Prospective Study

68Ga-PSMA-11 PET/CT in Newly Diagnosed Prostate Adenocarcinoma

2018 ◽  
Vol 43 (12) ◽  
pp. e422-e427 ◽  
Author(s):  
Nurhan Ergül ◽  
Burçak Yilmaz Güneş ◽  
Uğur Yücetaş ◽  
Mahmut Gökhan Toktaş ◽  
Tevfik Fikret Çermik
Keyword(s):  
Prostate Adenocarcinoma ◽  
Newly Diagnosed ◽  
Pet Ct
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