High grade transformation of salivary gland acinic cell carcinoma with emphasis on histological diagnosis and clinical implications

2016 ◽  
Vol 212 (11) ◽  
pp. 1059-1063 ◽  
Author(s):  
Danielle Bury ◽  
Mugtaba Dafalla ◽  
Shabada Ahmed ◽  
Henrik Hellquist
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Histological Diagnosis ◽  
Acinic Cell Carcinoma ◽  
Clinical Implications ◽  
High Grade ◽  
Acinic Cell ◽  
High Grade Transformation

scholarly journals Oncogenic Orphan Nuclear Receptor NR4A3 Interacts and Cooperates with MYB in Acinic Cell Carcinoma

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2433
Author(s):  
David Y. Lee ◽  
Kathryn J. Brayer ◽  
Yoshitsugu Mitani ◽  
Eric A. Burns ◽  
Pulivarthi H. Rao ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Salivary Gland Tumor ◽  
Binding Domain ◽  
Acinic Cell Carcinoma ◽  
High Grade ◽  
Orphan Nuclear Receptor ◽  
Acinic Cell ◽  
High Grade Transformation ◽  
Domain Transformation

Acinic cell carcinoma (AcCC) is a morphologically distinctive salivary gland malignancy often associated with chromosome rearrangements leading to overexpression of the NR4A3 transcription factor. However, little is known about how NR4A3 contributes to AcCC biology. Detailed RNA-sequencing of 21 archived AcCC samples revealed fusion reads arising from recurrent t(4;9), t(9;12), t(8;9) or t(2;4) chromosomal translocations, which positioned highly active enhancers adjacent to the promoter of the NR4A3 gene or the closely related NR4A2 gene, resulting in their aberrant overexpression. Transcriptome analyses revealed several distinct subgroups of AcCC tumors, including a subgroup that overexpressed both NR4A3 and MSANTD3. A poor survival subset of the tumors with high-grade transformation expressed NR4A3 and POMC as well as MYB, an oncogene that is the major driver in a different type of salivary gland tumor, adenoid cystic carcinoma. The combination of NR4A3 and MYB showed cooperativity in regulating a distinct set of genes. In addition, the ligand binding domain of NR4A3 directly bound the Myb DNA binding domain. Transformation assays indicated that, while overexpressed NR4A3 was sufficient to generate transformed colonies, the combination of NR4A3 plus Myb was more potent, leading to anchorage-independent growth and increased cellular invasiveness. The results confirm that NR4A3 and NR4A2 are the main driver genes of AcCC and suggest that concurrent overexpression of NR4A3 and MYB defines a subset of AcCC patients with high-grade transformation that display exceptionally poor outcome.

scholarly journals High-Grade Transformation of Acinic Cell Carcinoma: Potentially Underrecognized and Inadequately Treated

2016 ◽  
Vol 94 (4) ◽  
pp. 946
Author(s):  
A.V. Chintakuntlawar ◽  
W. Shon ◽  
M. Erickson-Johnson ◽  
E. Bilodeau ◽  
S. Jenkins ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Acinic Cell Carcinoma ◽  
High Grade ◽  
Acinic Cell ◽  
High Grade Transformation

scholarly journals Dedifferentiated Acinic Cell Carcinoma of the Parotid Gland With Myoepithelial Features

2002 ◽  
Vol 126 (9) ◽  
pp. 1104-1105 ◽  
Author(s):  
Simonetta Piana ◽  
Alberto Cavazza ◽  
Corrado Pedroni ◽  
Rosa Scotti ◽  
Luigi Serra ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Cell Carcinoma ◽  
Clinical Course ◽  
Acinic Cell Carcinoma ◽  
Low Grade ◽  
High Grade ◽  
Epithelial Proliferation ◽  
Acinic Cell

Abstract Dedifferentiated acinic cell carcinoma of the salivary gland is an uncommon variant of acinic cell carcinoma, characterized by the coexistence of both an usual low-grade acinic cell carcinoma and a high-grade dedifferentiated component, as well as by an accelerated clinical course. We describe a case of acinic cell carcinoma of the parotid gland in a 67-year-old woman, which recurred 4 times after surgery and radiotherapy. The recurrences consisted of residual foci of acinic cell carcinoma intermingled with a high-grade epithelial proliferation; the latter was focally constituted by cells with morphologic and immunohistochemical features of myoepithelium.

High-grade transformation of acinic cell carcinoma: an inadequately treated entity?

2016 ◽  
Vol 121 (5) ◽  
pp. 542-549.e1 ◽  
Author(s):  
Ashish V. Chintakuntlawar ◽  
Wonwoo Shon ◽  
Michele Erickson-Johnson ◽  
Elizabeth Bilodeau ◽  
Sarah M. Jenkins ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Acinic Cell Carcinoma ◽  
High Grade ◽  
Acinic Cell ◽  
High Grade Transformation

High-grade transformation in acinic cell carcinoma of the salivary glands: A rare but important clinical entity.

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. 5581-5581
Author(s):  
K. A. R. Price ◽  
W. Shon ◽  
J. A. Davidson ◽  
J. E. Lewis ◽  
D. L. Price ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Salivary Glands ◽  
Clinical Entity ◽  
Acinic Cell Carcinoma ◽  
High Grade ◽  
Acinic Cell ◽  
High Grade Transformation

scholarly journals Clinicopathologic and Immunophenotypic Characterization of 25 Cases of Acinic Cell Carcinoma with High-Grade Transformation

2015 ◽  
Vol 10 (2) ◽  
pp. 152-160 ◽  
Author(s):  
Lester D. Thompson ◽  
Muhammad N. Aslam ◽  
Jennifer N. Stall ◽  
Aaron M. Udager ◽  
Simion Chiosea ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Acinic Cell Carcinoma ◽  
High Grade ◽  
Acinic Cell ◽  
High Grade Transformation
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