Plexiform hybrid granular cell tumor/perineurioma: A novel variant of benign peripheral nerve sheath tumor with divergent differentiation

2012 ◽  
Vol 208 (5) ◽  
pp. 310-314 ◽  
Author(s):  
Alexandra Matter ◽  
Ekkehard Hewer ◽  
Andreas Kappeler ◽  
Achim Fleischmann ◽  
Istvan Vajtai
Keyword(s):  
Peripheral Nerve ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath ◽  
Divergent Differentiation ◽  
Novel Variant

A Rare Perineurioma/Granular Cell Tumor Hybrid Peripheral Nerve Sheath Tumor

2020 ◽  
Vol 42 (10) ◽  
pp. 762-765
Author(s):  
Koorosh Haghayeghi ◽  
Gladys Telang ◽  
Sonja Chen ◽  
Jack Bevivino ◽  
Shamlal Mangray ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath

Canine Peripheral Nerve Sheath Tumor with Eosinophilic Cytoplasmic Globules

1998 ◽  
Vol 35 (3) ◽  
pp. 223-226 ◽  
Author(s):  
M. Kuwamura ◽  
J. Yamate ◽  
T. Kotani ◽  
T. Takeuchi ◽  
S. Sakuma
Keyword(s):  
Peripheral Nerve ◽  
Tumor Cells ◽  
Periodic Acid ◽  
Neuron Specific Enolase ◽  
Granular Cell ◽  
Nerve Sheath Tumor ◽  
Periodic Acid Schiff ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath ◽  
Spindle Cell Proliferation

A 13-year-old male Shetland Sheepdog had a subcutaneous tumor in the left brachium. The tumor was removed and recurred several times at 5, 13, 16, 22, and 31 months after the initial presentation. Histologically, the removed nodules from the fourth resection were composed of neoplastic proliferation of round to fusiform cells, which possessed eosinophilic globules in their cytoplasm. The globules were periodic acid–Schiff positive and diastase resistant. Positive reactions for acid phosphatase were observed in the cytoplasm of the tumor cells. Ultrastructurally, these globules consisted of membrane-bound, dense structures containing dense granules, lucent vacuoles, and homogeneous materials. The recurrent tumors removed at the fifth resection consisted of spindle cell proliferation arranged in interlacing fascicles with wavy nuclei and containing a small number of cells with cytoplasmic globules. The tumor cells were immunoreactive to vimentin, S-100 protein, myelin basic protein, and neuron-specific enolase. The tumor was diagnosed as a peripheral nerve sheath tumor with eosinophilic cytoplasmic globules. These findings are unique for the histogenesis of granular cell tumors.

Malignant Peripheral Nerve Sheath Tumor With Divergent Differentiation

2003 ◽  
Vol 127 (3) ◽  
pp. e147-e150 ◽  
Author(s):  
Li Huang ◽  
Carmen Espinoza ◽  
Ronald Welsh
Keyword(s):  
African American ◽  
Peripheral Nerve ◽  
Pulmonary Embolus ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath ◽  
Spindle Cells ◽  
Divergent Differentiation ◽  
Rare Cells ◽  
Tumor Death

Abstract Right posterior thigh malignant peripheral nerve sheath tumor with malignant glandular and rhabdomyoblastic components was diagnosed in a 24-year-old African American man. Malignant glands and rhabdomyoblastic cells were admixed with the spindle cells. Immunohistochemistry demonstrated spindle cells positive for S100 and vimentin; the glandular component was positive for chromogranin, and rare cells were positive for CK20 but negative for CK7. Rhabdomyoblastic cells were positive for muscle-specific actin and desmin. A single pulmonary metastasis occurred 5 months after surgical resection of the tumor. Death occurred 1 month later and was probably due to a pulmonary embolus.

scholarly journals Malignant peripheral nerve sheath tumor with divergent differentiation

2009 ◽  
Vol 52 (1) ◽  
pp. 74 ◽  
Author(s):  
TN Suresh ◽  
ML Harendra Kumar ◽  
C.S.B.R Prasad ◽  
R Kalyani ◽  
K Borappa
Keyword(s):  
Peripheral Nerve ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath ◽  
Divergent Differentiation

scholarly journals Morphological spectrum of peripheral nerve sheath tumors: An insight into World Health Organization 2013 classification

2016 ◽  
Vol 07 (03) ◽  
pp. 346-354 ◽  
Author(s):  
Panduranga Chikkannaiah ◽  
Mythri M. Boovalli ◽  
Velusamy Nathiyal ◽  
Srinivasamurthy Venkataramappa
Keyword(s):  
Peripheral Nerve ◽  
Granular Cell Tumor ◽  
Malignant Tumors ◽  
Granular Cell ◽  
Cell Tumor ◽  
World Health ◽  
Nerve Sheath Tumors ◽  
Peripheral Nerve Sheath Tumors ◽  
Nerve Sheath ◽  
Health Organization

ABSTRACT Introduction: Peripheral nerve sheath tumors (PNSTs) are neuroectodermal in origin. Now these tumors are classified under World Health Organization (WHO) classification of tumors of soft tissue and bone 2013. Objective: To study the morphological spectrum of PNST and to study the secondary degenerative changes associated with it. Materials and Methods: This study was conducted from January 2010 to June 2015. The gross details of tumor and patient's demographic profiles were reviewed. The hematoxylin and eosin stained slides were reassessed and the lesions were categorized and classified as per the WHO 2013 classification. The tumors were also assessed for secondary degenerative changes. Results: Our study comprised 143 cases of PNST. Age of the patients ranged from 5 to 75 years. 21–30 years is the most common age of occurrence with head and neck being the most common site. The PNSTs observed in the present study were neurofibroma (NF) (61.5%), schwannoma (36%), malignant PNST (2%), and granular cell tumor (0.5%). Nearly 10% of NF fulfilled the criteria for neurofibromatosis 1 (NF1). Rare tumors such as plexiform schwannoma and granular cell tumor were also observed. Malignant tumors were larger in dimension than benign. Myxoid, cystic, and hyaline changes were commonly associated with benign tumors while necrosis, hemorrhage, and mitotic activity were seen with malignant tumors. Conclusion: This series highlights the pathological variants of PNST along with their morphological changes and NF1 association. It is essential to be familiar with all these variants of PNST for accurate diagnosis as they have varied biological behavior.

scholarly journals Granular Cell Tumor of Brachial Plexus Mimicking Nerve Sheath Tumor: A Case Report

2012 ◽  
Vol 9 (3) ◽  
pp. 275 ◽  
Author(s):  
Young-Im Kim ◽  
Chul-kyu Lee ◽  
Ki Hong Cho ◽  
Sang-Hyun Kim
Keyword(s):  
Case Report ◽  
Brachial Plexus ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Nerve Sheath Tumor ◽  
Nerve Sheath

Malignant Peripheral Nerve Sheath Tumor Arising from a Solitary Neurofibroma in a Patient without Neurofibromatosis Type 1

2016 ◽  
Vol 78 (5) ◽  
pp. 516-521
Author(s):  
Fumihisa SAWADA ◽  
Eiichi MAKINO ◽  
Takenobu YAMAMOTO ◽  
Ryo TANAKA ◽  
Yutaka FUJIWARA ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Neurofibromatosis Type 1 ◽  
Neurofibromatosis Type ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath ◽  
Solitary Neurofibroma
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