Reduced expression of Raf-1 kinase inhibitory protein predicts regional lymph node metastasis and shorter survival in esophageal squamous cell carcinoma

2012 ◽  
Vol 208 (5) ◽  
pp. 292-299 ◽  
Author(s):  
Hyun-Soo Kim ◽  
Kyu Yeoun Won ◽  
Gou Young Kim ◽  
Soo Cheol Kim ◽  
Yong-Koo Park ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Regional Lymph Node ◽  
Regional Lymph Node Metastasis ◽  
Inhibitory Protein ◽  
Node Metastasis

scholarly journals Cytoplasmic HDPR1 Is Involved in Regional Lymph Node Metastasis and Tumor Development via Beta-Catenin Accumulation in Esophageal Squamous Cell Carcinoma

2011 ◽  
Vol 59 (7) ◽  
pp. 711-718 ◽  
Author(s):  
Jian Hou ◽  
En-Min Li ◽  
Jin-Hui Shen ◽  
Qing-Zhao ◽  
Zhi-Yong Wu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Regional Lymph Node ◽  
Tumor Development ◽  
Regional Lymph Node Metastasis ◽  
Beta Catenin ◽  
Node Metastasis

The aim of this study was to evaluate HDPR1 expression in esophageal squamous cell carcinoma (ESCC) and the relationship between HDPR1 and beta-catenin by immunohistochemical analysis. The clinical relevance of these proteins was also analyzed. Immunohistochemistry was performed on paraffin-embedded tissue specimens from 184 ESCC patients to detect the expression of HDPR1 and beta-catenin. The correlation between the results of immunoexpression and the clinicopathologic features was processed statistically. Increased cytoplasmic and nuclear HDPR1 expression was noted in 100 (54.3%) and 131 (71.2%) of 184 specimens, respectively. Statistical analysis showed significant associations of cytoplasmic HDPR1 with regional lymph node metastasis ( p = 0.021) and P-stage ( p = 0.004). The increased nuclear staining was only correlated with P-stage ( p = 0.047). Significant associations of coexpression of cytoplasmic and nuclear HDPR1 with regional lymph node metastasis ( p = 0.015) or P-stage ( p = 0.002) were observed. Enhanced cytoplasmic expression of HDPR1 was positively correlated with increased cytoplasmic but not reduced membranous beta-catenin expression ( r = 0.239, p = 0.027 and r = 0.126, p = 0.089, respectively). These finding suggested that cytoplasmic HDPR1 protein expression was associated with tumor malignant progression via beta-catenin accumulation. It implicated that cytoplasmic HDPR1 expression may serve as a potential predictive factor for lymph node metastasis and tumor development in ESCC.

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