Differential expression of DUSP6 with expression of ERK and Ki-67 in non-small cell lung carcinoma

2011 ◽  
Vol 207 (7) ◽  
pp. 428-432 ◽  
Author(s):  
Hyunjung Lee ◽  
Jin Man Kim ◽  
Song-Mei Huang ◽  
Seung-Kiel Park ◽  
Dong-Hoon Kim ◽  
...  
Keyword(s):  
Differential Expression ◽  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Ki 67 ◽  
Cell Lung Carcinoma

Quantitation of Ki-67 Expression in the Differential Diagnosis of Reserve Cell Hyperplasia vs. Small Cell Lung Carcinoma

2004 ◽  
Vol 48 (5) ◽  
pp. 608-612 ◽  
Author(s):  
Johanna M. M. Grefte ◽  
Maria R. J. Salet-van de Pol ◽  
Johanna H. Gemmink ◽  
Johan Bulten ◽  
Antonius G. J. M. Hanselaar ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Hyperplasia ◽  
Ki 67 ◽  
Cell Lung Carcinoma ◽  
Reserve Cell

scholarly journals Prognostic significance of PD-L1 in advanced non-small cell lung carcinoma patients: a cohort study at a single institute

2019 ◽  
Author(s):  
Yanjie Zhao ◽  
Feng Shi ◽  
Quan Zhou ◽  
Yuchen Li ◽  
Jiangping Wu ◽  
...  
Keyword(s):  
Cohort Study ◽  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Prognostic Significance ◽  
Small Cell ◽  
Advanced Stage ◽  
Small Cell Lung ◽  
Ki 67 ◽  
Cell Lung Carcinoma ◽  
Expression Status

Abstract Background This study aimed to investigate the prognostic effect of PD-L1 on Chinese non-small cell lung carcinoma patients.Methods A retrospective cohort study was conducted and consecutively recruited 97 patients with non-small cell lung carcinoma. The expression status of PD-1, PD-L1, p53 and Ki-67 was detected by immunohistochemistry. Kaplan-Meier survival curve with log-rank test was used to estimate survival. Cox-Hazard Proportion regression model was used to estimate the hazard ratio and 95% confidence intervalResults The median tumor size was 3.5 cm and 2.0 cm among patients with positive and negative PD-L1 expression, respectively (p<0.001). The proportion of patients with positive and negative PD-L1 expression having nerve invasion was 26.3% and 5.0% (p<0.01). 47.4% patients with positive PD-L1 expression had blood vessel invasion compared with 20.0% patients with negative PD-L1 expression (p<0.01). 64.9% patients with positive PD-L1 expression had lymph node metastasis compared with 27.5% patients with negative PD-L1 expression (p<0.001). Patients with positive PD-L1 expression were more likely to be in advanced stage (p<0.001) and had higher Ki-67 index (p<0.01). PD-L1 expression status did not show any significant association with DFS or OS. However among advanced patients, HR of PD-L1 expression was 4.13 (95%CI 1.06, 16.12).Conclusions Positive PD-L1 expression is associated with poorer prognosis in advanced stage patients. Compare to patients with negative expression, patients with positive PD-L1 expression had more aggressive pathological features. Further prospective studies are needed to confirm the results.

scholarly journals CircRNA_100395 Carried by Exosomes From Adipose-Derived Mesenchymal Stem Cells Inhibits the Malignant Transformation of Non-Small Cell Lung Carcinoma Through the miR-141-3p-LATS2 Axis

2021 ◽  
Vol 9 ◽  
Author(s):  
Chong Zhang ◽  
Jinlin Cao ◽  
Wang Lv ◽  
Haibo Mou
Keyword(s):  
Biological Activity ◽  
Malignant Transformation ◽  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Tumour Volume ◽  
Small Cell ◽  
Signalling Pathway ◽  
Small Cell Lung ◽  
Ki 67 ◽  
Cell Lung Carcinoma

Objective: The specific purpose of this study is to investigate the impact exosomes from adipose-derived mesenchymal stem cell (AMSC) has on non-small cell lung carcinoma (NSCLC) and the relative applications. Methods: circ_100395, miR-141-3p, and LATS2 were expressed and detected in NSCLC and paracancerous tissues as well as NSCLC cell lines. Pearson correlation analysis, Dual-Luciferase Reporter Assay and RNA pull-down assay were used to validate their expression and interaction, respectively. After isolation and culture of AMSCs, exosomes were extracted and identified. EdU, epithelial-mesenchymal transition (EMT), and cell colony formation assay were used to distinguish the biological activity of the cells. Expression Hippo/YAP signalling pathway-related proteins were measured by western blotting. Subsequently, tumour volume and weight were confirmed based on xenograft nude mice models, Ki-67 and LATS2 expression was observed by immunohistochemistry. Results: circ_100395 was lowly expressed in NSCLC tissues or cells. The negative correlations and interactions were confirmed between circ_100395 and miR-141-3p, miR-141-3p, and LATS2. AMSC-derived exosomes with overexpression of circ_100395 (exo-circ_100395) significantly inhibited the biological activity as well as EMT of H1650 cells and Hippo/YAP signalling pathway activity. In addition, exo-circ_100395 markedly reduced tumour volume and weight as well as Ki-67 and LASP1 expression in vivo. However, overexpressed miR-141-3p or knocked down LATS2 alleviated the above effects. Conclusion: Exo-circ_100395 can increase LATS2 expression by sponging miR-141-3p to regulate Hippo/YAP signalling pathway, thereby inhibiting NSCLC malignant transformation.

CD117, Ki-67, and p53 predict survival in neuroendocrine carcinomas, but not within the subgroup of small cell lung carcinoma

Tumor Biology ◽  
2010 ◽  
Vol 32 (1) ◽  
pp. 107-111 ◽  
Author(s):  
Brian S. Erler ◽  
Matthew M. Presby ◽  
Meredith Finch ◽  
Allison Hodges ◽  
Kari Horowitz ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Ki 67 ◽  
Cell Lung Carcinoma ◽  
Neuroendocrine Carcinomas
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