The significance of Ki-67/MIB-1 labeling index in human meningiomas: A literature study

2010 ◽  
Vol 206 (12) ◽  
pp. 810-815 ◽  
Author(s):  
Ellen Abry ◽  
Ingrid Ø. Thomassen ◽  
Øyvind O. Salvesen ◽  
Sverre H. Torp
Keyword(s):  
Labeling Index ◽  
Literature Study ◽  
Ki 67 ◽  
Human Meningiomas ◽  
Mib 1

Residual nonfunctioning pituitary adenomas: prognostic value of MIB-1 labeling index for tumor progression

2009 ◽  
Vol 111 (3) ◽  
pp. 563-571 ◽  
Author(s):  
Georg Widhalm ◽  
Stefan Wolfsberger ◽  
Matthias Preusser ◽  
Ingeborg Fischer ◽  
Adelheid Woehrer ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Pituitary Adenomas ◽  
Residual Tumor ◽  
Labeling Index ◽  
Ki 67 ◽  
Nonfunctioning Pituitary Adenomas ◽  
Time Period ◽  
Tumor Group ◽  
Significant Difference ◽  
Mib 1

Object In residual nonfunctioning pituitary adenomas, reliable prognostic parameters indicating probability of tumor progression are needed. The Ki 67 expression/MIB-1 labeling index (LI) is considered to be a promising candidate factor. The aim in the present study was to analyze the clinical usefulness of MIB-1 LI for prognosis of tumor progression. Methods The authors studied a cohort of 92 patients with nonfunctioning pituitary adenomas. Based on sequential postoperative MR images, patients were classified as tumor free (51 patients) or as harboring residual tumor (41 individuals). The residual tumor group was further subdivided in groups with stable residual tumors (14 patients) or progressive residual tumors (27 patients). The MIB-1 LI was assessed in tumor specimens obtained in all patients, and statistical comparisons of MIB-1 LI of the various subgroups were performed. Results . The authors found no significant difference of MIB-1 LI in the residual tumor group compared with the tumor-free group. However, MIB-1 LI was significantly higher in the progressive residual tumor group, compared with the stable residual tumor group. Additionally, the time period to second surgery was significantly shorter in residual adenomas showing an MIB-1 LI > 3%. Conclusions The data indicate that MIB-1 LI in nonfunctioning pituitary adenomas is a clinically useful prognostic parameter indicating probability of progression of postoperative tumor remnants. The MIB-1 LI may be helpful in decisions of postoperative disease management (for example, frequency of radiographic intervals, planning for reoperation, radiotherapy, and/or radiosurgery).

scholarly journals MIB-1 labeling index, Ki-67, is an indicator of invasive intraductal papillary mucinous neoplasm

2016 ◽  
Vol 5 (2) ◽  
pp. 317-322 ◽  
Author(s):  
Tatsuo Shimura ◽  
Yasuhide Kofunato ◽  
Ryo Okada ◽  
Rei Yashima ◽  
Koji Okada ◽  
...  
Keyword(s):  
Intraductal Papillary Mucinous Neoplasm ◽  
Labeling Index ◽  
Ki 67 ◽  
Mucinous Neoplasm ◽  
Mib 1

Increased MIB-1/Ki-67 Labeling Index as a Predictor of an Aggressive Course in a Case of Prolactinoma

2004 ◽  
Vol 61 (3) ◽  
pp. 111-116 ◽  
Author(s):  
Taiba Zornitzki ◽  
Hilla Knobler ◽  
Dvora Nass ◽  
Moshe Hadani ◽  
Ilan Shimon
Keyword(s):  
Labeling Index ◽  
Ki 67 ◽  
Mib 1

The clinical value of Ki-67/MIB-1 labeling index in human astrocytomas

2006 ◽  
Vol 12 (3) ◽  
pp. 143-147 ◽  
Author(s):  
Anne Linn Johannessen ◽  
Sverre Helge Torp
Keyword(s):  
Labeling Index ◽  
Clinical Value ◽  
Ki 67 ◽  
Human Astrocytomas ◽  
Mib 1

Correlation Between Digital and Manual Determinations of Ki-67/MIB-1 Proliferative Indices in Human Meningiomas

2019 ◽  
Vol 28 (3) ◽  
pp. 273-279 ◽  
Author(s):  
Duc-Tien Pham ◽  
Ivar Skaland ◽  
Theo L. Winther ◽  
Øyvind Salvesen ◽  
Sverre H. Torp
Keyword(s):  
Cox Regression ◽  
Rank Correlation ◽  
Tissue Microarrays ◽  
World Health ◽  
Daily Routine ◽  
Ki 67 ◽  
Human Meningiomas ◽  
Health Organization ◽  
Proliferative Indices ◽  
Mib 1

Objective. Proliferative activity in tumor tissues is assessed as the percentage of Ki-67/MIB-1-positive cells, or the proliferative index (PI). The PI is routinely assessed manually. However, the subjectivity of manual assessments might result in poor reproducibility. We hypothesized that digital assessments might reduce the error. Method. In our study, we assessed Ki-67/MIB-1 PIs, both manually and digitally, with tissue microarrays constructed from 141 human meningioma samples. Spearman-rank correlation and κ statistics were applied for correlation and agreement analyses, respectively. Mann-Whitney U tests were used to compare MIB-1 PIs between groups. Prognostic ability was assessed with Kaplan-Meier and Cox regression analyses. Results. We found a significant, high correlation (Spearman ρ = 0.832, P < .01) and moderate agreement (κ coefficient = 0.617, observed agreement = 80.9%) between the 2 methods. Both methods found significantly different Ki-67/MIB-1 PIs for different World Health Organization grades ( P < .05). Neither method showed significant prognostic value. Conclusion. Digital determinations of Ki-67/MIB-1 PIs in human meningiomas are feasible for the daily routine.

Correlation between the bromodeoxyuridine labeling index and the MIB-1 and Ki-67 proliferating cell indices in cerebral gliomas

Cancer ◽  
1994 ◽  
Vol 74 (7) ◽  
pp. 1921-1926 ◽  
Author(s):  
Kiyoshi Onda ◽  
Richard L. Davis ◽  
Makoto Shibuya ◽  
Charles B. Wilson ◽  
Takao Hoshino
Keyword(s):  
Labeling Index ◽  
Ki 67 ◽  
Cerebral Gliomas ◽  
Proliferating Cell ◽  
Mib 1

Value of KI-67/MIB-1 labeling index and simpson grading system to predict the recurrence of who grade I intracranial meningiomas compared to who grade II

2021 ◽  
Vol 86 ◽  
pp. 32-37
Author(s):  
Ricardo Prat-Acín ◽  
María Juliana Guarín-Corredor ◽  
Inma Galeano-Senabre ◽  
Angel Ayuso-Sacido ◽  
Francisco Vera-Sempere
Keyword(s):  
Labeling Index ◽  
Grading System ◽  
Ki 67 ◽  
Who Grade ◽  
Intracranial Meningiomas ◽  
Grade Ii ◽  
Mib 1
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