Differential expression of Janus kinase 3 (JAK3), matrix metalloproteinase 13 (MMP13), heat shock protein 60 (HSP60), and mouse double minute 2 (MDM2) in human colorectal cancer progression using human cancer cDNA microarrays

2005 ◽  
Vol 201 (12) ◽  
pp. 777-789 ◽  
Author(s):  
Daisuke Mori ◽  
Yuji Nakafusa ◽  
Kohji Miyazaki ◽  
Osamu Tokunaga
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Human Cancer ◽  
Janus Kinase ◽  
Heat Shock Protein 60 ◽  
Human Colorectal Cancer ◽  
Matrix Metalloproteinase 13 ◽  
Mouse Double Minute ◽  
Double Minute ◽  
Colorectal Cancer Progression

scholarly journals Sophoridine Inhibits Human Colorectal Cancer Progression via Targeting MAPKAPK2

2019 ◽  
Vol 17 (12) ◽  
pp. 2469-2479 ◽  
Author(s):  
Rui Wang ◽  
Hongwei Liu ◽  
Yingying Shao ◽  
Kailong Wang ◽  
Shuangshuang Yin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Progression

scholarly journals Patterns of methylation of the c-myc gene in human colorectal cancer progression

1992 ◽  
Vol 65 (5) ◽  
pp. 667-672 ◽  
Author(s):  
RM Sharrard ◽  
JA Royds ◽  
S Rogers ◽  
AJ Shorthouse
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Human Colorectal Cancer ◽  
Myc Gene ◽  
Colorectal Cancer Progression

scholarly journals lncRNA GAU1 Induces GALNT8 Overexpression and Potentiates Colorectal Cancer Progression

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Xuemei Tang ◽  
Haoyu Ruan ◽  
Liu Dong ◽  
Sihan Li ◽  
Zhiyuan Wu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Human Cancer ◽  
Enrichment Analysis ◽  
Cancer Cell Proliferation ◽  
Cancer Transcriptome ◽  
Tcga Dataset ◽  
Colorectal Cancer Progression ◽  
In Vitro Treatment

lncRNA is a key epigenetic regulator in biological processes. In the human cancer transcriptome library MiTranscriptome, we identified GAU1 as the top upregulated lncRNA in colorectal cancer (CRC) by sample set enrichment analysis (overexpression ranking percentile = 99.75 %, P < 10 − 50 ), which is coexpressed with the potential oncogene GALNT8 (Spearman rho = 0.67 , P = 2.44 × 10 − 23 , TCGA dataset n = 184 ). Experimental data revealed that GAU1 regulates the expression of GALNT8. The overexpression of either GAU1 or GALNT8 significantly promotes the cell cycle and proliferation of CRC cell lines and correlates with poor prognosis in patients with CRC ( P = 3.04 × 10 − 2 ), while silencing of GAU1 or GALNT8 suppressed the cancer cell proliferation and induced the CRC cell line resistance to oxaliplatin in vitro treatment. Our results suggested that the previously less studied GAU1 and GALNT8 may play as CRC prognosis markers and potential targets for chemotherapy treatment.

scholarly journals Human colorectal cancer progression correlates with LOX-induced ECM stiffening

2017 ◽  
Vol 13 (11) ◽  
pp. 1450-1457 ◽  
Author(s):  
Bo Wei ◽  
Xueling Zhou ◽  
Chenghua Liang ◽  
Xiaoming Zheng ◽  
Purun Lei ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Progression

LIMK/cofilin pathway and Slingshot are implicated in human colorectal cancer progression and chemoresistance

2018 ◽  
Vol 472 (5) ◽  
pp. 727-737 ◽  
Author(s):  
Helen Aggelou ◽  
Panagiota Chadla ◽  
Sofia Nikou ◽  
Sofia Karteri ◽  
Ioannis Maroulis ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Progression

scholarly journals Interleukin-11 is a Marker for Both Cancer- and Inflammation-Associated Fibroblasts that Contribute to Colorectal Cancer Progression

2020 ◽  
Author(s):  
Takashi Nishina ◽  
Yutaka Deguchi ◽  
Wakami Takeda ◽  
Masato Ohtsuka ◽  
Daisuke Ohshima ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Human Cancer ◽  
Tumor Development ◽  
Disease Free Survival ◽  
Reporter Mice ◽  
Stat3 Phosphorylation ◽  
Colorectal Cancer Progression ◽  
Cancer And Inflammation

SUMMARYInterleukin (IL)-11 is a member of the IL-6 family of cytokines and involved in multiple cellular responses, including tumor development. However, the origin and functions of IL-11-producing (IL-11+) cells are not fully understood. To characterize IL-11+ cells in vivo, we generated Il11 reporter mice. IL-11+ cells appeared in the colon of three murine tumor models, and a murine acute colitis model. Il11ra1 or Il11 deletion attenuated the development of colitis-associated colorectal cancer. IL-11+ cells expressed fibroblast markers, and genes associated with cell proliferation and tissue repair. IL-11 induced STAT3 phosphorylation in colonic fibroblasts, suggesting the activation of IL-11+ fibroblasts. Analysis using the human cancer database revealed that genes enriched in IL-11+ fibroblasts were elevated in human colorectal cancer, and correlated with reduced disease-free survival. Together, our results suggested that tumor cells induced IL-11+ fibroblasts, and that a feed-forward loop between IL-11 and IL-11+ fibroblasts might contribute to tumor development.

Differential Expression of the L-Plastin Gene in Human Colorectal Cancer Progression and Metastasis

2001 ◽  
Vol 289 (4) ◽  
pp. 876-881 ◽  
Author(s):  
Motoyuki Otsuka ◽  
Masaki Kato ◽  
Tsutomu Yoshikawa ◽  
Hua Chen ◽  
Eric J. Brown ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Differential Expression ◽  
Cancer Progression ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Progression
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