scholarly journals Nutritional effects of folic acid controlled release from mesoporous materials

2011 ◽  
Vol 1 ◽  
pp. 1828-1832 ◽  
Author(s):  
José Barat ◽  
Édgar Pérez-Esteve ◽  
Andrea Bernardos ◽  
Ramón Martínez-Mañez
Keyword(s):  
Folic Acid ◽  
Controlled Release ◽  
Mesoporous Materials ◽  
Nutritional Effects

Influence of the structural and textural properties of ordered mesoporous materials and hierarchical zeolitic supports on the controlled release of methylprednisolone hemisuccinate

2014 ◽  
Vol 2 (45) ◽  
pp. 7996-8004 ◽  
Author(s):  
R. A. García-Muñoz ◽  
V. Morales ◽  
M. Linares ◽  
P. E. González ◽  
R. Sanz ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Mesoporous Materials ◽  
Textural Properties ◽  
Effective Drug ◽  
Hierarchical Zeolite ◽  
Ordered Mesoporous Materials ◽  
Drug Delivery Vehicles ◽  
Ordered Mesoporous ◽  
Delivery Vehicles

Influence of structural and textural properties of mesostructured siliceous and hierarchical zeolite materials in designing effective drug delivery vehicles.

scholarly journals Polymer Composites Containing Gated Mesoporous Materials for On-Command Controlled Release

2014 ◽  
Vol 6 (9) ◽  
pp. 6453-6460 ◽  
Author(s):  
Carolina Acosta ◽  
Edgar Pérez-Esteve ◽  
Carlos A. Fuenmayor ◽  
Simona Benedetti ◽  
Maria Stella Cosio ◽  
...  
Keyword(s):  
Controlled Release ◽  
Polymer Composites ◽  
Mesoporous Materials

scholarly journals Ethyl Cellulose Microcapsules for Protecting and Controlled Release of Folic Acid

2009 ◽  
Vol 10 (4) ◽  
Author(s):  
Satit Prasertmanakit ◽  
Nalena Praphairaksit ◽  
Worawadee Chiangthong ◽  
Nongnuj Muangsin
Keyword(s):  
Folic Acid ◽  
Controlled Release ◽  
Ethyl Cellulose

scholarly journals Controlled release of targeted anti-leukemia drugs azacitidine and decitabine monitored using surface-enhanced Raman scattering (SERS) spectroscopy

2017 ◽  
Vol 6 (4) ◽  
pp. 125-132 ◽  
Author(s):  
Madison Smith ◽  
Maria Hepel
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Controlled Release ◽  
Drug Release ◽  
Raman Scattering ◽  
Cancer Cells ◽  
Surface Enhanced Raman Scattering ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

A new targeted drug delivery system with controlled release of anti-cancer drugs, azacitidine and decitabine, was investigated to enhance the efficacy of cancer treatment and reduce the effects of high drug toxicity to healthy tissues. The proposed drug nanocarriers are based on gold nanoparticles (AuNPs) modified with mercaptobenzoic acid (MBA) linker to enable the immobilization of azacitidine (AZA) and decitabine (DAC) on AuNPs in the form of AuNP@MBA/AZA,DAC entities. The cancer cell recognition was accomplished by covalently binding folic acid (FA) ligands to para-aminothiophenol (PATP) in the mixed SAM shell on gold nanoparticle nanocarriers, AuNP@MBA,PATP. The FA ligand was used due to the strong expression of folic acid receptors (FR) in the membrane of cancer cells. This enables the functionalized carriers to target only cancer cells owing to the efficient FA-FR binding property. The amide bonds between the linkers and azacitidine/decitabine are pH sensitive and undergo acid hydrolysis in a low pH environment of the cytosol in cancer cells. Using the solutions of different pH, the release of azacitidine/decitabine was monitored by surface-enhanced Raman scattering spectroscopy (SERS) measurements of the MBA Raman modes at 1586 cm-1 and 1074 cm-1 . At pH 7.4, the release of the drug was found to be negligible, while at pH 4.0 and 5.5 a continuous drug release was observed over 3 hours. The utilization of SERS monitoring for the drug release was based on the strong Raman signals which are generated by the MBA linker when it is bound to a plasmonic AuNP. During the immobilization of azacitidine/decitabine on AuNP carriers, the SERS signals are strongly reduced due to the shielding by drug molecules but they increase sharply upon the drug release confirming the amide bond breakage and successful drug delivery.

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