The oxidation of kerosene and bio-kerosene (kerosene-rapeseed oil methyl esters 80/20 in mole) was studied experimentally in a jet-stirred reactor at 10 atm and constant residence time, over the high temperature range 740-1200 K, and for variable equivalence ratios in the range 0.5–1.5. Concentration profiles of reactants, stable intermediates, and final products were obtained by probe sampling followed by on-line and off-line GC analyses. The oxidation of these fuels in these conditions was modeled using a detailed kinetic reaction mechanism consisting of 2027 reversible reactions and 263 species. The surrogate bio-kerosene model-fuel used consisted of a mixture of n-hexadecane, n-propylcyclohexane, n-propylbenzene, and n-decane. For bio-kerosene, the methyl ester fraction was simply represented by n-hexadecane. The proposed kinetic reaction mechanism used in the modeling yielded a good representation of the kinetics of oxidation of kerosene and bio-kerosene under JSR conditions. The data and the model showed the bio-kerosene (Jet A-1/RME mixture) has a slightly higher reactivity than Jet A-1 whereas not major modification of the products distribution was observed besides the formation of small methyl esters from RME’s oxidation.