scholarly journals Prostate cancer trajectory-map: clinical decision support system for prognosis management of radical prostatectomy

Author(s):  
Jihwan Park ◽  
Mi Jung Rho ◽  
Hyong Woo Moon ◽  
Yong Hyun Park ◽  
Choung-Soo Kim ◽  
...  
2020 ◽  
Vol 10 (4) ◽  
pp. 1333 ◽  
Author(s):  
Sun Jung Lee ◽  
Sung Hye Yu ◽  
Yejin Kim ◽  
Jae Kwon Kim ◽  
Jun Hyuk Hong ◽  
...  

Prostate cancer is the fourth most common cancer affecting South Korean males, and the biochemical recurrence (BCR) of prostate cancer occurs in approximately 25% of patients five years after radical prostatectomy. The ability to predict BCR would help clinicians and patients to make better treatment decisions. Therefore, in this study, we have proposed a web-based clinical decision support system that predicts the BCR of prostate cancer in Korean patients. The data were obtained from the Korean Prostate Cancer Registry (KPCR) database, which contained information about 7394 patients with prostate cancer who were treated at one of the six major medical institutions in South Korea between May 2001 and December 2014. We tested 13 prediction models and selected the gradient boosting classifier because it demonstrated excellent prediction performance. Using this model, we were able to create a web application and once clinical data from patients were entered, the three- and five-year post-surgery BCR predictions could be extracted. We developed a clinical decision support system to provide a prostate cancer BCR predictive function to facilitate postoperative follow-up and clinical management. This system will help clinicians develop a strategic approach for prostate cancer treatment by predicting the likelihood of prostate cancer recurrence.


Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1309-P
Author(s):  
JACQUELYN R. GIBBS ◽  
KIMBERLY BERGER ◽  
MERCEDES FALCIGLIA

2020 ◽  
Vol 16 (3) ◽  
pp. 262-269
Author(s):  
Tahere Talebi Azad Boni ◽  
Haleh Ayatollahi ◽  
Mostafa Langarizadeh

Background: One of the greatest challenges in the field of medicine is the increasing burden of chronic diseases, such as diabetes. Diabetes may cause several complications, such as kidney failure which is followed by hemodialysis and an increasing risk of cardiovascular diseases. Objective: The purpose of this research was to develop a clinical decision support system for assessing the risk of cardiovascular diseases in diabetic patients undergoing hemodialysis by using a fuzzy logic approach. Methods: This study was conducted in 2018. Initially, the views of physicians on the importance of assessment parameters were determined by using a questionnaire. The face and content validity of the questionnaire was approved by the experts in the field of medicine. The reliability of the questionnaire was calculated by using the test-retest method (r = 0.89). This system was designed and implemented by using MATLAB software. Then, it was evaluated by using the medical records of diabetic patients undergoing hemodialysis (n=208). Results: According to the physicians' point of view, the most important parameters for assessing the risk of cardiovascular diseases were glomerular filtration, duration of diabetes, age, blood pressure, type of diabetes, body mass index, smoking, and C reactive protein. The system was designed and the evaluation results showed that the values of sensitivity, accuracy, and validity were 85%, 92% and 90%, respectively. The K-value was 0.62. Conclusion: The results of the system were largely similar to the patients’ records and showed that the designed system can be used to help physicians to assess the risk of cardiovascular diseases and to improve the quality of care services for diabetic patients undergoing hemodialysis. By predicting the risk of the disease and classifying patients in different risk groups, it is possible to provide them with better care plans.


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