Reproducibility of flow properties of microcrystalline cellulose — Avicel PH102

2011 ◽  
Vol 212 (1) ◽  
pp. 253-257 ◽  
Author(s):  
Limin Shi ◽  
Sayantan Chattoraj ◽  
Changquan Calvin Sun
Keyword(s):  
Microcrystalline Cellulose ◽  
Flow Properties

Optimization of Microcrystalline Cellulose PH 101, Lactose, and Kollidon® K 30 To Obtain Co-Processed Excipient Through Spray Drying

2017 ◽  
Vol 7 (2) ◽  
Author(s):  
Kusuma P. ◽  
Syukri Y ◽  
Sholehuddin F. ◽  
Fazzri N. ◽  
Romdhonah . ◽  
...  
Keyword(s):  
Spray Drying ◽  
Microcrystalline Cellulose ◽  
Chemical Change ◽  
Direct Compression ◽  
Flow Properties ◽  
Scanning Calorimetry ◽  
Compression Process ◽  
Infrared Spectrophotometer ◽  
Physical Mixtures ◽  
Spray Dried

The most efficient tablet processing method is direct compression. For this method, the filler-binder can be made by coprocessing via spray drying method. The purpose of this study was to investigate the effect of spray dried co-processing on microcrystalline cellulose (MCC) PH 101, lactose and Kollidon® K 30 as well as to define the optimum proportions. Spray dried MCC PH 101, lactose, and Kollidon® K 30 were varied in 13 different mixture design proportions to obtain compact, free-flowing filler-binder co-processed excipients (CPE). Compactibility and flow properties became the key parameters to determine the optimum proportions of CPE that would be compared to their physical mixtures. The result showed that the optimum proportion of CPE had better compactibility and flow properties than the physical mixtures. The optimum CPE, consisting of only MCC PH 101 and Kollidon® K 30 without lactose, that were characterized using infrared spectrophotometer, differential scanning calorimetry (DSC), X-ray diffraction (XRD), and scanning electron microscope (SEM) indicated no chemical change therein. Therefore, this study showed that spray dried MCC PH 101, lactose and Kollidon® K 30 could be one of the filler-binder alternatives for direct compression process.

Rheology and microstructure of concentrated microcrystalline cellulose (MCC)/1-allyl-3-methylimidazolium chloride (AmimCl)/water mixtures

Soft Matter ◽  
2018 ◽  
Vol 14 (37) ◽  
pp. 7615-7624 ◽  
Author(s):  
Ashna Rajeev ◽  
Abhijit P. Deshpande ◽  
Madivala G. Basavaraj
Keyword(s):  
Microcrystalline Cellulose ◽  
Flow Properties ◽  
Solvent Quality

Water added to a solution of microcrystalline cellulose (MCC) in 1-allyl-3-methylimidazolium chloride (AmimCl) reduces the solvent quality and causes significant changes in the flow properties and microstructure due to restructuring and aggregation of cellulose molecules.

scholarly journals The effect of magnesium stearate and sodium starch glycolate on powder flowability

2019 ◽  
pp. 304-310
Author(s):  
Gordana Svonja-Parezanovic ◽  
Mladena Lalic-Popovic ◽  
Svetlana Golocorbin-Kon ◽  
Nemanja Todorovic ◽  
Nebojsa Pavlovic ◽  
...  
Keyword(s):  
Microcrystalline Cellulose ◽  
Magnesium Stearate ◽  
Angle Of Repose ◽  
Flow Properties ◽  
Sodium Starch Glycolate ◽  
Compressibility Index ◽  
Powder Flowability ◽  
The Individual ◽  
Full Factorial ◽  
Spray Dried

The powder flow plays an important role in the manufacture of dosage form such as direct compression tablets. The objective of this research was to investigate the individual and interaction effects of magnesium stearate (MgSt) (Merck Ltd., Germany) as lubricant and sodium starch glycolate (SSG) (Primojel?) as superdesintegrator on powder flowability. Powder formulations were prepared by mixing different concentration of MgSt (0.25% and 5%) and SSG (0.5% and 4%) with microcrystalline cellulose (MCC) (Vivapur?101) or spray-dried lactose (LAC) (Super Tab 21AN) as diluents. Eight powder formulations were prepared using as filler LAC and MCC, as superdesintegrator SSG and as lubricant MgSt in ratios as follows: P1 (LAC : 0.5% SSG : 0.25% MgSt); P2 (LAC : 4% SSG : 5% MgSt); P3 (LAC : 0.5% SSG : 5% MgSt); P4 (LAC : 4% SSG : 5% MgSt); P5 (MCC : 0.5% SSG : 0.25% MgSt); P6 (MCC : 4% SSG : 5% MgSt); P7 (MCC : 0.5% SSG : 5% MgSt); P8 (MCC : 4% SSG : 0.25% MgSt). The powder formulations were evaluated using indirect methods of flowability evaluation according to 9th European Pharmacopoeia: measurement of tapped and bulk density (Ph.Eur.9, 2.9.34) and angle of repose (Ph.Eur. 2.9.36). Also, compressibility index, Hausner?s ratio were calculated. A full factorial design with three factors at two levels and response surface methodology were applied to evaluate the influence of various concentrations of MgSt and SSG on powder flowability. The results indicate that flow properties improved with decrease of SSG content and with increase of MgSt content. Magnesium stearate in powder formulations with microcrystalline cellulose has a greater influence on the improvement of the flow properties than powder formulations with spray-dried lactose.

scholarly journals Production and Evaluation of Disintegrant Properties of Microcrystalline Cellulose Derived from SaccharumofficinarumL (Poaceae) in Metronidazole Based Formulation

2021 ◽  
Vol 6 (4) ◽  
pp. 42-51
Author(s):  
Oraeluno J.N. ◽  
Obasi J.C ◽  
Bamigbola E.A ◽  
Joseph B.A
Keyword(s):  
Microcrystalline Cellulose ◽  
Release Profile ◽  
Tablet Formulation ◽  
Maize Starch ◽  
Flow Properties ◽  
British Pharmacopoeia ◽  
Comparative Characterization ◽  
High Release ◽  
Dissolution Properties

The aim of the study was to produce microcrystalline cellulose from Saccharumofficinarum and to evaluate its use as a disintegrant in metronidazole tablet formulation. Cellulose was produced and characterized. This was followed by a comparative characterization of the tablets formulated by using Saccharumofficinarummicrocrystalline cellulose (SO-MCC), maize starch and crosscarmellose sodium (Ac-di-sol®) as disintegrants. The granules were evaluated for flow properties and the tablet evaluated for hardness, friability, disintegration and dissolution properties. For disintegration studies, the disintegrants disintegrated within 10 minutes in this order: Ac-di-sol® >SO-MCC>Maize starch. All the tablets exhibited high release profile which conformed to British Pharmacopoeia standards. Hence, SO-MCC can be used as an alternative disintegrant in terms of cost and availability.

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