Microanalysis of hybrid characterization of PLA/cHA polymer scaffolds for bone regeneration

2020 ◽  
Vol 83 ◽  
pp. 106341 ◽  
Author(s):  
Bankole I. Oladapo ◽  
Ilesanmi A. Daniyan ◽  
Omolayo M. Ikumapayi ◽  
Olaoluwa B. Malachi ◽  
Idowu O. Malachi
Keyword(s):  
Bone Regeneration ◽  
Polymer Scaffolds ◽  
Hybrid Characterization

Characterization of biomimetic silicate- and strontium-containing hydroxyapatite microparticles embedded in biodegradable electrospun polycaprolactone scaffolds for bone regeneration

2019 ◽  
Vol 113 ◽  
pp. 67-77 ◽  
Author(s):  
Roman A. Surmenev ◽  
Svetlana Shkarina ◽  
Dina S. Syromotina ◽  
Elizaveta V. Melnik ◽  
Roman Shkarin ◽  
...  
Keyword(s):  
Bone Regeneration

Fabrication and characterization of bovine hydroxyapatite-gelatin-alendronate scaffold cross-linked by glutaraldehyde for bone regeneration

2021 ◽  
Vol 32 (4) ◽  
pp. 555-560
Author(s):  
Samirah ◽  
Aniek Setiya Budiatin ◽  
Ferdiansyah Mahyudin ◽  
Junaidi Khotib
Keyword(s):  
Compressive Strength ◽  
Bone Regeneration ◽  
Mtt Assay ◽  
Local Treatment ◽  
Swelling Ratio ◽  
High Concentration ◽  
Proliferation And Differentiation ◽  
Bovine Hydroxyapatite

Abstract Objectives Alendronate are widely used in the treatment of bone disorders characterized by inhibit osteoclast-mediated bone resorption such as Paget’s disease, fibrous dysplasia, myeloma, bone metastases and osteoporosis. In recent studies alendronate improves proliferation and differentiation of osteoblasts, thereby facilitating for bone regeneration. The disadvantages of this class are their poor bioavailability and side effects on oral and intravenous application such as stomach irritation and osteonecrosis in jaw. Thus, local treatment of alendronate is needed in order to achieve high concentration of drug. Bovine hydroxyapatite-gelatin scaffold with alendronate was studied. Glutaraldehyde was used as cross-linking agent, increase the characteristics of this scaffold. The objectives of this study were to manufacture and characterize alendronate scaffold using bovine hydroxyapatite-gelatin and crosslinked by glutaraldehyde. Methods Preparation of cross-linked bovine hydroxyapatite-gelatin and alendronate scaffold with different concentration of glutaraldehyde (0.00, 0.50, 0.75, and 1.00%). The scaffolds were characterized for compressive strength, porosity, density, swelling ratio, in vitro degradation, and cytotoxicity (the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, shorted as MTT assay). Results Bovine hydroxyapatite-gelatin-alendronate scaffold cross-linked with glutaraldehyde showed lower density than without glutaraldehyde. As glutaraldehyde concentration increased, porosity also increased. Eventually, it reduced compressive strength. Swelling ratio and in vitro degradation was negatively dependent on glutaraldehyde concentration. In addition, the scaffold has a good safety by MTT assay. Conclusions Bovine hydroxyapatite-gelatin-alendronate scaffold was fabricated with various concentrations of glutaraldehyde. The presence of glutaraldehyde on bovine hydroxyapatite-gelatin-alendronate is safe and suitable candidate scaffold for bone regeneration.

scholarly journals Crystallographic characterization of eggshells as scaffolds for bone regeneration

2014 ◽  
Vol 70 (a1) ◽  
pp. C1104-C1104
Author(s):  
Margarita García-Garduño ◽  
Laura Vargas-Ulloa ◽  
Genoveva Hernández-Padrón
Keyword(s):  
Bone Regeneration ◽  
High Speed ◽  
Energy Dispersive Spectrometer ◽  
Chemical Components ◽  
Cross Sectional ◽  
Calcium Carbonates ◽  
Organic Part ◽  
Major Chemical ◽  
Osseous Regeneration

The aim of this work was to characterize six different eggshell types as future osseous regeneration scaffolds. The study design was cross-sectional observational. The study was conducted in the Laboratory of Materials and the chemical analysis in the Faculty of Chemistry, UNAM, Mexico. Fifty samples of fresh eggs were obtained, 10 from each species (hen, turkey, duck, dove and quail). Square-shaped pieces of about 2 x 2 cm were obtained from the eggshells by means of a high-speed handpiece with a # 701 carbide bur. From the total of eggshell pieces, the ones coming from fresh eggs were included, and the ones showing signs of fracture or spots were excluded. Their morphology was analyzed with a low vacuum scanning electron microscope (JEOL 5200), with an accelerating voltage of 20 kV. The chemical elemental analysis was performed with an EDAX energy dispersive spectrometer (EDS) and the chemical composition was determined by means of a Siemens diffractometer. All of the eggshells were constituted by calcium carbonates, and their outer structure was less porous than the inner one, sometimes with granules and cuticles firmly attached to the inner surface of the eggshell. The eggshell major chemical components were mainly: oxygen, calcium, phosphorous, magnesium, sulfur and carbon. There are no significant quantities of sulfur (S) in the turkey and quail eggshells. These kinds of eggshells have not been tested yet as a scaffold, but it is expected that they may be used soon in bone regeneration once the organic part is removed. Eggshells are largely waste material. The authors anknowledge the technical support to Chem. Rafael Ivan Puente Lee

Design and characterization of a novel chitosan/nanocrystalline calcium phosphate composite scaffold for bone regeneration

2009 ◽  
Vol 88A (2) ◽  
pp. 491-502 ◽  
Author(s):  
Betsy M. Chesnutt ◽  
Ann M. Viano ◽  
Youling Yuan ◽  
Yunzhi Yang ◽  
Teja Guda ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Composite Scaffold

scholarly journals Characterization of Biodegradable/Bioresorbable Polymer Scaffolds for Osteoblast Cell Growth by SEM and TEM

2002 ◽  
Vol 8 (S02) ◽  
pp. 758-759
Author(s):  
S. Iadarola ◽  
A. Crugnola ◽  
R. Joshi ◽  
J. Tessier ◽  
C. Sung
Keyword(s):  
Cell Growth ◽  
Osteoblast Cell ◽  
Polymer Scaffolds ◽  
Sem And Tem ◽  
Bioresorbable Polymer

Microarchitectural and mechanical characterization of oriented porous polymer scaffolds

Biomaterials ◽  
2003 ◽  
Vol 24 (3) ◽  
pp. 481-489 ◽  
Author(s):  
Angela S.P Lin ◽  
Thomas H Barrows ◽  
Sarah H Cartmell ◽  
Robert E Guldberg
Keyword(s):  
Mechanical Characterization ◽  
Porous Polymer ◽  
Polymer Scaffolds
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