Salt-, pH- and temperature-responsive semi-interpenetrating polymer network hydrogel based on poly(aspartic acid) and poly(acrylic acid)

Polymer ◽  
2006 ◽  
Vol 47 (22) ◽  
pp. 7702-7710 ◽  
Author(s):  
Ying Zhao ◽  
Juan Kang ◽  
Tianwei Tan
Keyword(s):  
Acrylic Acid ◽  
Aspartic Acid ◽  
Polymer Network ◽  
Interpenetrating Polymer Network ◽  
Temperature Responsive ◽  
Poly Acrylic Acid

Synthesis and Characteristics of Interpenetrating Polymer Network Hydrogels Based on Konjac Glucomannan with Different Molecular Weights and Poly(acrylic acid)

2011 ◽  
Vol 393-395 ◽  
pp. 1004-1007
Author(s):  
Xue Yao ◽  
Xue Gang Luo ◽  
Ben Chao Han
Keyword(s):  
Acrylic Acid ◽  
Enzymatic Degradation ◽  
Drug Carrier ◽  
Polymer Network ◽  
Konjac Glucomannan ◽  
Interpenetrating Polymer Network ◽  
Swelling Ratio ◽  
Molecular Weights ◽  
Ft Ir ◽  
Poly Acrylic Acid

Konjac glucomannan with different molecular weights/poly(acrylic acid) hydrogels were prepared in this paper. The structure of the IPN hydrogels was characterized by FT-IR and SEM. The swelling ratio of these hydrogels showed they had pH-sensitive properties and the enzymatic degradation tests showed the hydrogels retain the enzymatic degradation character of KGM. Furthermore, hydrogel composed of native KGM degraded sharply in enzymatic degradation test and it had bigger swelling ratio and weight loss ratio than those hydrogels which composed of lower molecular weights KGM. Therefore, hydrogels composed of lower molecular weight might release drug more stable when they were used as drug carrier.

Water Behavior of Poly(acrylic acid)/ Poly (acrylonitrile) Semi-Interpenetrating Polymer Network Hydrogels

2004 ◽  
Vol 16 (4) ◽  
pp. 625-635 ◽  
Author(s):  
Seon Jeong Kim ◽  
Ki Jung Lee ◽  
Sang Min Lee ◽  
In Young Kim ◽  
Sun I. Kim
Keyword(s):  
Acrylic Acid ◽  
Polymer Network ◽  
Interpenetrating Polymer Network ◽  
Water Behavior ◽  
Poly Acrylonitrile ◽  
Poly Acrylic Acid

Optimal response surface design of Gum tragacanth-based poly[(acrylic acid)-co-acrylamide] IPN hydrogel for the controlled release of the antihypertensive drug losartan potassium

RSC Advances ◽  
2014 ◽  
Vol 4 (75) ◽  
pp. 39822-39829 ◽  
Author(s):  
Saruchi Saruchi ◽  
B. S. Kaith ◽  
Rajeev Jindal ◽  
Vaneet Kumar ◽  
Manpreet S. Bhatti
Keyword(s):  
Controlled Release ◽  
Acrylic Acid ◽  
Polymer Network ◽  
Interpenetrating Polymer Network ◽  
Losartan Potassium ◽  
Surface Design ◽  
Gum Tragacanth ◽  
Ph Conditions ◽  
Poly Acrylic Acid

The present study proposes the development and optimization of a new interpenetrating polymer network (IPN), consisting of Gum tragacanth, poly(acrylic acid) (PAA), and poly(acrylamide) (PAAm), for the in situ controlled release of losartan potassium under different pH conditions at 37 °C.

scholarly journals Preparation and In Vitro Evaluation of Aspartic/Alginic Acid Based Semi-Interpenetrating Network Hydrogels for Controlled Release of Ibuprofen

Gels ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. 68
Author(s):  
Muhammad Suhail ◽  
Yi-Han Hsieh ◽  
Arshad Khan ◽  
Muhammad Usman Minhas ◽  
Pao-Chu Wu
Keyword(s):  
Drug Release ◽  
Acrylic Acid ◽  
Aspartic Acid ◽  
Alginic Acid ◽  
Drug Loading ◽  
Polymer Network ◽  
Interpenetrating Polymer Network ◽  
Polymerization Process ◽  
Ph Dependent

Different combinations of polymers, aspartic acid (ASP), alginic acid (AL), and monomer acrylic acid (AA) were crosslinked in the presence of an initiator ammonium peroxodisulfate (APS) and cross-linker ethylene glycol dimethacrylate (EGDMA) to develop aspartic acid/alginic acid-co-poly(acrylic acid) (ASP/ALPAA) (semi-interpenetrating polymer network (SIPN)) hydrogels by the free radical polymerization technique for the controlled delivery of ibuprofen (IBP). Various studies such as dynamic swelling studies, drug loading, in vitro drug release and sol−gel analysis were carried out for the hydrogels. Higher swelling was observed at higher pH 7.4 as compared to lower pH 1.2, due to the presence of carboxylic groups of polymers and the monomer. Hence, pH-dependent swelling was exhibited by the developed hydrogels which led to a pH-dependent drug release and vice versa. The structural properties of the hydrogels were assessed by FTIR, PXRD, TGA, DSC, and SEM which confirmed the fabrication and stability of the developed structure. FTIR analysis revealed the reaction of both polymers with the monomer during the polymerization process and confirmed the overlapping of the monomer on the backbone of the both polymers. The disappearance of high intense crystalline peaks and the encapsulation of the drug by the hydrogel network was confirmed by PXRD. TGA and DSC showed that the developed hydrogels were thermally more stable than their basic ingredients. Similarly, the surface morphology of the hydrogels was analyzed by SEM and showed a smooth surface with few pores. Conclusively, ASP/ALPAA hydrogels have the potential to deliver IBP for a long period of time in a controlled way.

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