A novel water soluble axially substituted silicon(IV) phthalocyanine bearing quaternized 4-(4-pyridinyl)phenol groups: Synthesis, characterization, photophysicochemical properties and BSA/DNA binding behavior

Polyhedron ◽  
2021 ◽  
Vol 194 ◽  
pp. 114937
Author(s):  
Shaya Y. Al-Raqa ◽  
Khaoula Khezami ◽  
Esra Nur Kaya ◽  
Mahmut Durmuş
Keyword(s):  
Dna Binding ◽  
Water Soluble ◽  
Binding Behavior

Water soluble palladium(ii) and platinum(ii) acyclic diaminocarbene complexes: solution behavior, DNA binding, and antiproliferative activity

2020 ◽  
Vol 44 (15) ◽  
pp. 5762-5773 ◽  
Author(s):  
Tatiyana V. Serebryanskaya ◽  
Mikhail A. Kinzhalov ◽  
Vladimir Bakulev ◽  
Georgii Alekseev ◽  
Anastasiya Andreeva ◽  
...  
Keyword(s):  
Dna Binding ◽  
Antiproliferative Activity ◽  
Water Soluble ◽  
Solution Behavior ◽  
Antitumor Potential ◽  
Acyclic Diaminocarbene

Water soluble Pd(ii) and Pt(ii)–ADC species synthesized via the metal-mediated coupling of isocyanides and 1,2-diaminobenzene have demonstrated antitumor potential.

Water-soluble copper(II) complexes with 4,5-dichloro-isothiazole-3-carboxylic acid and heterocyclic N-donor ligands: Synthesis, crystal structures, cytotoxicity, and DNA binding study

2020 ◽  
Vol 510 ◽  
pp. 119778 ◽  
Author(s):  
Julia A. Eremina ◽  
Elizaveta V. Lider ◽  
Taisiya S. Sukhikh ◽  
Lyubov S. Klyushova ◽  
Maria L. Perepechaeva ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Dna Binding ◽  
Crystal Structures ◽  
Water Soluble ◽  
Binding Study ◽  
Donor Ligands

scholarly journals Synthesis and Guest-Binding Properties of pH/Reduction Dual-Responsive Cyclophane Dimer

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3097
Author(s):  
Osamu Hayashida ◽  
Yudai Tanaka ◽  
Takaaki Miyazaki
Keyword(s):  
Electrostatic Interaction ◽  
Disulfide Bonds ◽  
Water Soluble ◽  
Guest Molecules ◽  
Binding Behavior ◽  
Dual Responsive ◽  
Guest Binding ◽  
Basic Solutions ◽  
Ph Conditions ◽  
Almost All

A water-soluble cyclophane dimer having two disulfide groups as a reduction-responsive cleavable bond as well as several acidic and basic functional groups as a pH-responsive ionizable group 1 was successfully synthesized. It was found that 1 showed pH-dependent guest-binding behavior. That is, 1 strongly bound an anionic guest, 6-p-toluidinonaphthalene-2-sulfonate (TNS) with binding constant (K/M−1) for 1:1 host-guest complexes of 9.6 × 104 M−1 at pH 3.8, which was larger than those at pH 7.4 and 10.7 (6.0 × 104 and 2.4 × 104 M−1, respectively), indicating a favorable electrostatic interaction between anionic guest and net cationic 1. What is more, release of the entrapped guest molecules by 1 was easily controlled by pH stimulus. Large favorable enthalpies (ΔH) for formation of host-guest complexes were obtained under the pH conditions employed, suggesting that electrostatic interaction between anionic TNS and 1 was the most important driving force for host-guest complexation. Such contributions of ΔH for formation of host-guest complexes decreased along with increased pH values from acidic to basic solutions. Upon addition of dithiothreitol (DTT) as a reducing reagent to an aqueous PBS buffer (pH 7.4) containing 1 and TNS, the fluorescence intensity originating from the bound guest molecules decreased gradually. A treatment of 1 with DTT gave 2, having less guest-binding affinity by the cleavage of disulfide bonds of 1. Consequently, almost all entrapped guest molecules by 1 were released from the host. Moreover, such reduction-responsive cleavage of 1 and release of bound guest molecules was performed more rapidly in aqueous buffer at pH 10.7.

DNA Binding Behavior, Sensor Studies, Antimicrobial, Photocleavage and In vitro Cytotoxicity of Synthesized Ru(II) Complexes with Assorted Intercalating Polypyridyl Ligands

2016 ◽  
Vol 26 (3) ◽  
pp. 1101-1113 ◽  
Author(s):  
Rajender Reddy Mallepally ◽  
Venkat Reddy Putta ◽  
Nagamani Chintakuntla ◽  
Ravi Kumar Vuradi ◽  
Laxma Reddy Kotha ◽  
...  
Keyword(s):  
Dna Binding ◽  
In Vitro Cytotoxicity ◽  
Polypyridyl Ligands ◽  
Binding Behavior

Acid–base properties and DNA-binding of water soluble N-confused porphyrins with cationic side-arms

2008 ◽  
Vol 6 (22) ◽  
pp. 4157 ◽  
Author(s):  
Yoshiya Ikawa ◽  
Shoji Moriyama ◽  
Hiroyuki Harada ◽  
Hiroyuki Furuta
Keyword(s):  
Dna Binding ◽  
Water Soluble ◽  
Acid Base ◽  
Base Properties

Molecular binding behavior of bipyridium derivatives by water-soluble carboxylato-biphen[3]arene

2015 ◽  
Vol 51 (30) ◽  
pp. 6621-6624 ◽  
Author(s):  
Junwei Ma ◽  
Hongmei Deng ◽  
Suxiang Ma ◽  
Jian Li ◽  
Xueshun Jia ◽  
...  
Keyword(s):  
Water Soluble ◽  
Molecular Binding ◽  
Binding Behavior

Complexation of paraquat derivatives and bis(N-mono-substituted bipyridine) cations by a negatively charged carboxylato-biphen[3]arene in water is described.

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