Dinuclear ruthenium(II) polypyridyl complexes: Mechanistic study with biomolecules, DNA/BSA interactions and cytotoxic activity

Polyhedron ◽  
2020 ◽  
Vol 178 ◽  
pp. 114334 ◽  
Author(s):  
Milica Medjedović ◽  
Ana Rilak Simović ◽  
Dušan Ćoćić ◽  
Milan Milutinović ◽  
Laura Senft ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Mechanistic Study ◽  
Polypyridyl Complexes ◽  
Dinuclear Ruthenium

scholarly journals Design, Synthesis and Pharmacological Evaluation of Three Novel Dehydroabietyl Piperazine Dithiocarbamate Ruthenium (II) Polypyridyl Complexes as Potential Antitumor Agents: DNA Damage, Cell Cycle Arrest and Apoptosis Induction

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1453
Author(s):  
Haoran Wang ◽  
Jianhua Wei ◽  
Hong Jiang ◽  
Ye Zhang ◽  
Caina Jiang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Cell Cycle Arrest ◽  
Antitumor Agents ◽  
Mechanistic Study ◽  
Ros Generation ◽  
Polypyridyl Complexes ◽  
Expression Levels ◽  
Cycle Arrest ◽  
Study Results

The use of cisplatin is severely limited by its toxic side-effects, which has spurred chemists to employ different strategies in the development of new metal-based anticancer agents. Here, three novel dehydroabietyl piperazine dithiocarbamate ruthenium (II) polypyridyl complexes (6a–6c) were synthesized as antitumor agents. Compounds 6a and 6c exhibited better in vitro antiproliferative activity against seven tumor cell lines than cisplatin, they displayed no evident resistance in the cisplatin-resistant cell line A549/DPP. Importantly, 6a effectively inhibited tumor growth in the T-24 xenograft mouse model in comparison with cisplatin. Gel electrophoresis assay indicated that DNA was the potential targets of 6a and 6c, and the upregulation of p-H2AX confirmed this result. Cell cycle arrest studies demonstrated that 6a and 6c arrested the cell cycle at G1 phase, accompanied by the upregulation of the expression levels of the antioncogene p27 and the down-regulation of the expression levels of cyclin E. In addition, 6a and 6c caused the apoptosis of tumor cells along with the upregulation of the expression of Bax, caspase-9, cytochrome c, intracellular Ca2+ release, reactive oxygen species (ROS) generation and the downregulation of Bcl-2. These mechanistic study results suggested that 6a and 6c exerted their antitumor activity by inducing DNA damage, and consequently causing G1 stage arrest and the induction of apoptosis.

Modulation of Internuclear Communication in Multinuclear Ruthenium(II) Polypyridyl Complexes

2003 ◽  
Vol 68 (8) ◽  
pp. 1467-1487 ◽  
Author(s):  
Wesley R. Browne ◽  
Frances Weldon ◽  
Adrian Guckian ◽  
Johannes G. Vos
Keyword(s):  
Ground State ◽  
Weak Interactions ◽  
Electrochemical Studies ◽  
Protonation State ◽  
Ruthenium Polypyridyl ◽  
Bridging Ligands ◽  
Polypyridyl Complexes ◽  
Bridging Ligand ◽  
Dinuclear Ruthenium ◽  
Ruthenium Polypyridyl Complexes

The syntheses and characterisation of a series of mononuclear and dinuclear ruthenium polypyridyl complexes based on the bridging ligands 1,3-bis-[5-(2-pyridyl)-1H-1,2,4-triazol-3-yl]benzene, 1,4-bis-[5-(2-pyridyl)-1H-1,2,4-triazol-3-yl]benzene, 2,5-bis-[5-(2-pyridyl)-1H-1,2,4-triazol-3-yl]thiophene, 2,5-bis-[5-pyrazinyl-1H-1,2,4-triazol-3-yl]thiophene are reported. Electrochemical studies indicate that in these systems, the ground state interaction is critically dependent on the nature of the bridging ligand and its protonation state, with strong and weak interactions being observed for thiophene- and phenylene-bridged complexes, respectively.

Evaluation of anticancer activity in vitro and in vivo of iridium(iii) polypyridyl complexes

2019 ◽  
Vol 43 (22) ◽  
pp. 8566-8579 ◽  
Author(s):  
Miao He ◽  
Qiao-Yan Yi ◽  
Wen-Yao Zhang ◽  
Lan Bai ◽  
Fan Du ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Membrane Potential ◽  
Cytotoxic Activity ◽  
Anticancer Activity ◽  
Cell Cycle Arrest ◽  
Mitochondrial Membrane ◽  
Polypyridyl Complexes ◽  
Cycle Arrest

Three new iridium(iii) polypyridyl complexes were synthesized. The cytotoxic activity in vitro and in vivo, apoptosis, cell cycle arrest, mitochondrial membrane potential, ROS and the expression of Bcl-2 family proteins were investigated.

scholarly journals Self-assembled supramolecular cages containing dinuclear ruthenium(II) polypyridyl complexes

2017 ◽  
Vol 458 ◽  
pp. 122-128 ◽  
Author(s):  
Chao Shen ◽  
Aaron D.W. Kennedy ◽  
William A. Donald ◽  
Allan M. Torres ◽  
William S. Price ◽  
...  
Keyword(s):  
Polypyridyl Complexes ◽  
Dinuclear Ruthenium ◽  
Self Assembled

Dinuclear ruthenium(ii) polypyridyl complexes as single and two-photon luminescence cellular imaging probes

2014 ◽  
Vol 50 (17) ◽  
pp. 2123 ◽  
Author(s):  
Wenchao Xu ◽  
Jiarui Zuo ◽  
Lili Wang ◽  
Liangnian Ji ◽  
Hui Chao
Keyword(s):  
Cellular Imaging ◽  
Polypyridyl Complexes ◽  
Two Photon ◽  
Imaging Probes ◽  
Dinuclear Ruthenium

scholarly journals Assessment of intercomponent interaction in phenylene bridged dinuclear ruthenium(ii) and osmium(ii) polypyridyl complexes

2004 ◽  
pp. 3943 ◽  
Author(s):  
Adrian L. Guckian ◽  
Manfred Doering ◽  
Michael Ciesielski ◽  
Olaf Walter ◽  
Johan Hjelm ◽  
...  
Keyword(s):  
Polypyridyl Complexes ◽  
Dinuclear Ruthenium

scholarly journals Synthesis, Characterization, Cytotoxic Activity, and Metabolic Studies of Ruthenium(II) Polypyridyl Complexes Containing Flavonoid Ligands

2020 ◽  
Vol 59 (7) ◽  
pp. 4424-4434 ◽  
Author(s):  
Alexandra-Cristina Munteanu ◽  
Anna Notaro ◽  
Marta Jakubaszek ◽  
Joseph Cowell ◽  
Mickaël Tharaud ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Polypyridyl Complexes ◽  
Metabolic Studies
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