Heterocyclic thioamide/phosphine mixed-ligand silver(I) complexes: Synthesis, molecular structures, DNA-binding properties and antibacterial activity

Polyhedron ◽  
2018 ◽  
Vol 151 ◽  
pp. 131-140 ◽  
Author(s):  
Despoina Varna ◽  
Eleni Kapetanaki ◽  
Alexandra Koutsari ◽  
Antonios G. Hatzidimitriou ◽  
George Psomas ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Dna Binding ◽  
Mixed Ligand ◽  
Molecular Structures ◽  
Binding Properties ◽  
Dna Binding Properties

scholarly journals Antibacterial Activity and DNA Binding Properties of Bivalent Metal Complexes of Cuminaldehyde Acetoylhydrazone

2021 ◽  
Vol 37 (5) ◽  
pp. 1125-1131
Author(s):  
Y.B. Nagamani ◽  
K. Hussain Reddy ◽  
K. Srinivasulu ◽  
D. Dhanalakshmi ◽  
K. Anuja
Keyword(s):  
Antibacterial Activity ◽  
Dna Binding ◽  
Binding Constants ◽  
Dna Interactions ◽  
Bivalent Metal ◽  
Binding Properties ◽  
Hydrazone Ligand ◽  
Metal Compounds ◽  
Physico Chemical ◽  
Dna Binding Properties

Metallo-hydrazones having the formula [M(IBAH)2] (where, M = Ni(II), Cu(II) and Zn(II); IBAH = p-Isopropylbenzaldehyde acetoylhydrazone) are prepared and confirmed on the basis of physico-chemical and spectral analyses. Conductivity data revealed that the complexes are non-electrolytes. Metal-DNA interactions are investigated using absorption spectrophotometry. Binding constant (Kb) data revealed that the copper complex interact DNA more strongly than other complexes. Antibacterial activity studies indicated higher activity for complexes than the metal free hydrazone ligand. The copper compound displays higher activity. DNA binding constants are correlated with the activity of metal compounds in this article.

Synthesis, characterization, DNA binding properties, and biological activities of a mixed ligand copper(II) complex of ofloxacin

2009 ◽  
Vol 34 (7) ◽  
pp. 757-763 ◽  
Author(s):  
Chang-Yun Chen ◽  
Quan-Zhan Chen ◽  
Xiao-Feng Wang ◽  
Min-Sheng Liu ◽  
Yun-Feng Chen
Keyword(s):  
Dna Binding ◽  
Biological Activities ◽  
Mixed Ligand ◽  
Binding Properties ◽  
Dna Binding Properties

DNA-Binding Properties of Iron(II) Mixed-Ligand Complexes Containing 1,10-Phenanthroline and Dipyrido[3,2-a:2’,3’-c]phenazine

2004 ◽  
Vol 59 (3) ◽  
pp. 310-318 ◽  
Author(s):  
◽  
Karna Wijaya ◽  
Daryono H. Tjahjono ◽  
Naoki Yoshioka ◽  
Hidenari Inoue
Keyword(s):  
Dna Binding ◽  
Bathochromic Shift ◽  
Mixed Ligand Complex ◽  
Visible Region ◽  
Spectrophotometric Titration ◽  
Mixed Ligand ◽  
Ligand Complex ◽  
Binding Properties ◽  
Ct Dna ◽  
Dna Binding Properties

An iron(II) mixed-ligand complex with 1,10-phenanthroline (phen) and dipyrido[3,2-a:2’,3’- c]phenazine (dppz), [Fe(phen)2(dppz)]2+, has been synthesized. The DNA-binding properties of the mixed-ligand complex have been studied in terms of equilibrium binding constant, thermodynamic parameter, thermal denaturation as well as Pfeiffer effect upon binding to DNA. The spectrophotometric titration of [Fe(phen)2(dppz)]2+ with calf thymus DNA (ct-DNA) has shown that the iron(II) mixed-ligand complex binds effectively to ct-DNA in an intercalation mode as indicated by remarkable hypochromicity (ca. 36%) and moderate bathochromic shift (8 nm) of the absorption spectra. This intercalative mode is supported by a significant increase (Δ Tm = 21 °C) in the melting temperature (Tm) of ct-DNA at R([complex]/[ct-DNA]) = 1.5. The binding of [Fe(phen)2(dppz)]2+ to ct-DNA is entropically driven as characterized by a positive enthalpy change and a large negative TΔ S term. An intense CD signal in the UV and visible region develops upon addition of ct-DNA to the racemate solution of [Fe(phen)2(dppz)]2+. This has revealed that a shift in diastereomeric inversion equilibrium takes place in the solution to yield an excess of one enantiomer of the DNA-iron(II) complex (Pfeiffer effect). The striking resemblance of the CD spectral profiles to those of the corresponding Δ -enantiomer indicates that Δ -[Fe(phen)2(dppz)]2+ is preferentially bound to ct-DNA

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