Copper, nickel and zinc complexes of 3-acetyl coumarin thiosemicarbazone: Synthesis, characterization and in vitro evaluation of cytotoxicity and DNA/protein binding properties

Polyhedron ◽  
2017 ◽  
Vol 135 ◽  
pp. 26-35 ◽  
Author(s):  
K.N. Anees Rahman ◽  
Jebiti Haribabu ◽  
Chandrasekar Balachandran ◽  
Nattamai S.P. Bhuvanesh ◽  
Ramasamy Karvembu ◽  
...  
2010 ◽  
Vol 11 (8) ◽  
pp. 2864-2874 ◽  
Author(s):  
Pornanong Aramwit ◽  
Pornprom Muangman ◽  
Nantaporn Namviriyachote ◽  
Teerapol Srichana

2019 ◽  
Vol 37 (16) ◽  
pp. 4238-4250 ◽  
Author(s):  
Ziba Sorinezami ◽  
Hassan Mansouri-Torshizi ◽  
Mohammad Aminzadeh ◽  
Arezou Ghahghaei ◽  
Nasimeh Jamgohari ◽  
...  

2017 ◽  
Vol 2017 ◽  
pp. 1-7
Author(s):  
Wan Raihana Wan Aasim ◽  
Soo Choon Tan ◽  
Siew Hua Gan

Abuse of 3,4-methylenedioxymethamphetamine (MDMA) is becoming more common worldwide. To date, there is no information available on stereoselectivity of MDMA protein binding in humans, rats, and mice. Since stereoselectivity plays an important role in MDMA’s pharmacokinetics and pharmacodynamics, in this study we investigated its stereoselectivity in protein binding. The stereoselective protein binding ofrac-MDMA was investigated using two different concentrations (20 and 200 ng/mL) in human plasma and mouse and rat sera using an ultrafiltration technique. No significant stereoselectivity in protein binding was observed in both human plasma and rat serum; however, a significant stereoselective binding (p<0.05) was observed in mouse serum. Since the protein binding of MDMA in mouse serum is considerably lower than in humans and rats, caution should be exercised when using mice for in vitro studies involving MDMA.


2001 ◽  
Vol 120 (5) ◽  
pp. A316-A317
Author(s):  
P MAERTEN ◽  
S COLPAERT ◽  
Z LIU ◽  
K GEBOES ◽  
J CEUPPENS ◽  
...  

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