Synthesis, structural analysis, redox properties and in vitro antitumor evaluation of half-sandwich complexes of Ru(II) with aminocoumarins

Polyhedron ◽  
2017 ◽  
Vol 127 ◽  
pp. 307-314 ◽  
Author(s):  
Anna Skoczynska ◽  
Magdalena Małecka ◽  
Marcin Cieslak ◽  
Julia Kazmierczak-Baranska ◽  
Karolina Krolewska-Golinska ◽  
...  
Keyword(s):  
Structural Analysis ◽  
Redox Properties ◽  
Sandwich Complexes ◽  
Antitumor Evaluation ◽  
Half Sandwich

scholarly journals Cytotoxic effect, generation of reactive oxygen/nitrogen species and electrochemical properties of Cu(ii) complexes in comparison to half-sandwich complexes of Ru(ii) with aminochromone derivatives

RSC Advances ◽  
2019 ◽  
Vol 9 (55) ◽  
pp. 31943-31952
Author(s):  
Paulina Mucha ◽  
Pawel Hikisz ◽  
Krzysztof Gwoździński ◽  
Urszula Krajewska ◽  
Andrzej Leniart ◽  
...  
Keyword(s):  
Electrochemical Properties ◽  
Cytotoxic Effect ◽  
Reactive Oxygen ◽  
Redox Properties ◽  
Nitrogen Species ◽  
Sandwich Complexes ◽  
Chromone Derivatives ◽  
Half Sandwich

New Cu(ii)/Ru(ii) complexes with 6-aminoflavone/chromone derivatives as ligands were synthesized and characterized. Their cytotoxicity, pro-oxidative and redox properties were investigated.

Half-Sandwich Ru(p-cymene) Compounds with Diphosphanes: In Vitro and In Vivo Evaluation As Potential Anticancer Metallodrugs

2021 ◽  
Vol 60 (5) ◽  
pp. 2914-2930
Author(s):  
Oscar A. Lenis-Rojas ◽  
M. Paula Robalo ◽  
Ana Isabel Tomaz ◽  
Alexandra R. Fernandes ◽  
Catarina Roma-Rodrigues ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Half Sandwich ◽  
Anticancer Metallodrugs

scholarly journals In Silico Structural Modeling and Analysis of Interactions of Tremellomycetes Cytochrome P450 Monooxygenases CYP51s with Substrates and Azoles

2021 ◽  
Vol 22 (15) ◽  
pp. 7811
Author(s):  
Olufunmilayo Olukemi Akapo ◽  
Joanna M. Macnar ◽  
Justyna D. Kryś ◽  
Puleng Rosinah Syed ◽  
Khajamohiddin Syed ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Structural Analysis ◽  
In Silico ◽  
Web Application ◽  
Cytochrome P450 Monooxygenases ◽  
Agglomerative Clustering ◽  
Ligand Complex ◽  
P450 Monooxygenase ◽  
Study Results

Cytochrome P450 monooxygenase CYP51 (sterol 14α-demethylase) is a well-known target of the azole drug fluconazole for treating cryptococcosis, a life-threatening fungal infection in immune-compromised patients in poor countries. Studies indicate that mutations in CYP51 confer fluconazole resistance on cryptococcal species. Despite the importance of CYP51 in these species, few studies on the structural analysis of CYP51 and its interactions with different azole drugs have been reported. We therefore performed in silico structural analysis of 11 CYP51s from cryptococcal species and other Tremellomycetes. Interactions of 11 CYP51s with nine ligands (three substrates and six azoles) performed by Rosetta docking using 10,000 combinations for each of the CYP51-ligand complex (11 CYP51s × 9 ligands = 99 complexes) and hierarchical agglomerative clustering were used for selecting the complexes. A web application for visualization of CYP51s’ interactions with ligands was developed (http://bioshell.pl/azoledocking/). The study results indicated that Tremellomycetes CYP51s have a high preference for itraconazole, corroborating the in vitro effectiveness of itraconazole compared to fluconazole. Amino acids interacting with different ligands were found to be conserved across CYP51s, indicating that the procedure employed in this study is accurate and can be automated for studying P450-ligand interactions to cater for the growing number of P450s.

Half-sandwich complexes of Group 9 metals with N,Nʹ-ligands for CF3-carbenoid alkylation of N-(pyrimidin-2-yl)indole

2021 ◽  
pp. 121899
Author(s):  
Sofya S. Kuvshinova ◽  
Yulia V. Nelyubina ◽  
Vladimir A. Larionov ◽  
Daria V. Vorobyeva ◽  
Sergey N. Osipov ◽  
...  
Keyword(s):  
Sandwich Complexes ◽  
Half Sandwich

scholarly journals Uranium(iv) cyclobutadienyl sandwich compounds: synthesis, structure and chemical bonding

2020 ◽  
Vol 56 (6) ◽  
pp. 944-947 ◽  
Author(s):  
Nikolaos Tsoureas ◽  
Akseli Mansikkamäki ◽  
Richard A. Layfield
Keyword(s):  
Chemical Bonding ◽  
Molecular Structures ◽  
Sandwich Complexes ◽  
Sandwich Complex ◽  
Sandwich Compounds ◽  
Bonding Properties ◽  
Half Sandwich

The synthesis, molecular structures and bonding properties of two uranium(iv) cyclobutadienyl half-sandwich complexes and a doubly activated cyclobutadienyl sandwich complex are described.

Evaluation of Paclitaxel Nanocrystals In Vitro and In Vivo

Drug Research ◽  
2017 ◽  
Vol 68 (04) ◽  
pp. 205-212 ◽  
Author(s):  
Wanqing Li ◽  
Zhiguo Li ◽  
Lisha Wei ◽  
Aiping Zheng
Keyword(s):  
Drug Concentration ◽  
Antitumor Effects ◽  
High Drug ◽  
High Drug Concentration ◽  
Low Toxicity ◽  
Nanoparticle Drug Delivery ◽  
Antitumor Evaluation ◽  
Mcf 7

AbstractWe created a novel paclitaxel (PTX) nanoparticle drug delivery system and compared this to acommercial injection preparation to evaluate the antitumor effects for both formulations in vivo and in vitro.PTXnanocrystals were 194.9 nm with potential of −29.6 mV. Cytotoxicity tests indicated that both formulations had similar effects and cytotoxicity was dose- and time-dependent.Pharmacodynamics indicated that the drug concentration at the tumor was greater with PTX nanocrystals compared to commercial injection (P<0.01) and that drug accumulated more and for a longer duration. In vivo antitumor evaluation indicated significant antitumor effects and low toxicity of PTX nanocrystals. Moreover, bioimaging indicated that the PTX retention time in MCF-7-bearing mice was longer, especially at the tumor site, and this high drug concentration was maintained for a long time.Overall, PTX nanocrystalsare feasible and superior to traditional injection formulation chemotherapy.

scholarly journals The synthesis and unexpected solution chemistry of thermochromic carborane-containing osmium half-sandwich complexes

2016 ◽  
Vol 45 (4) ◽  
pp. 1763-1768 ◽  
Author(s):  
Anaïs Pitto-Barry ◽  
Amy South ◽  
Alison Rodger ◽  
Nicolas P. E. Barry
Keyword(s):  
Solution Chemistry ◽  
Sandwich Complexes ◽  
Lewis Bases ◽  
Half Sandwich

The functionalisation of the 16-electron complex [Os(η6-p-cymene)(1,2-dicarba-closo-dodecarborane-1,2-dithiolato)] (1) with a series of Lewis bases to give the corresponding 18-electron complexes is reported.

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