A series of mononuclear nickel(II) complexes of Schiff-base ligands having N,N,O- and N,N,N-donor sites: Syntheses, crystal structures, solid state thermal property and catecholase-like activity

Polyhedron ◽  
2013 ◽  
Vol 52 ◽  
pp. 669-678 ◽  
Author(s):  
Averi Guha ◽  
Kazi Sabnam Banu ◽  
Sudhanshu Das ◽  
Tanmay Chattopadhyay ◽  
Ria Sanyal ◽  
...  
Keyword(s):  
Schiff Base ◽  
Solid State ◽  
Thermal Property ◽  
Crystal Structures ◽  
Schiff Base Ligands

Syntheses, crystal structures and density functional theory investigations of copper(ii) complexes bearing tridentate Schiff base ligands derived from 8-aminoquinoline

CrystEngComm ◽  
2015 ◽  
Vol 17 (30) ◽  
pp. 5664-5671 ◽  
Author(s):  
Prasanta Kumar Bhaumik ◽  
Antonio Bauzá ◽  
Michael G. B. Drew ◽  
Antonio Frontera ◽  
Shouvik Chattopadhyay
Keyword(s):  
Density Functional Theory ◽  
Schiff Base ◽  
Solid State ◽  
Dft Calculations ◽  
Crystal Structures ◽  
Density Functional ◽  
Schiff Base Complexes ◽  
Schiff Base Ligands ◽  
Functional Theory ◽  
Tridentate Schiff Base

Three copper(ii) Schiff base complexes have been synthesized and characterized. Supramolecular assemblies in the solid state are analyzed by DFT calculations.

New Copper Compounds with Antiplatelet Aggregation Activity

2019 ◽  
Vol 15 (8) ◽  
pp. 850-862
Author(s):  
Mirthala Flores-García ◽  
Juan Manuel Fernández-G. ◽  
Cristina Busqueta-Griera ◽  
Elizabeth Gómez ◽  
Simón Hernández-Ortega ◽  
...  
Keyword(s):  
Schiff Base ◽  
Solid State ◽  
Thrombotic Event ◽  
X Ray Diffraction ◽  
Nmr Studies ◽  
Schiff Base Ligands ◽  
X Ray ◽  
Antiplatelet Aggregation ◽  
Aggregation Activity ◽  
L1 And L2

Background: Ischemic heart disease, cerebrovascular accident, and venous thromboembolism have the presence of a thrombotic event in common and represent the most common causes of death within the population. Objective: Since Schiff base copper(II) complexes are able to interact with polyphosphates (PolyP), a procoagulant and potentially prothrombotic platelet agent, we investigated the antiplatelet aggregating properties of two novel tridentate Schiff base ligands and their corresponding copper( II) complexes. Methods: The Schiff base ligands (L1) and (L2), as well as their corresponding copper(II) complexes (C1) and (C2), were synthesized and characterized by chemical analysis, X-ray diffraction, mass spectrometry, and UV-Visible, IR and far IR spectroscopy. In addition, EPR studies were carried out for (C1) and (C2), while (L1) and (L2) were further analyzed by 1H and 13C NMR. Tests for antiplatelet aggregation activities of all of the four compounds were conducted. Results: X-ray diffraction studies show that (L1) and (L2) exist in the enol-imine tautomeric form with a strong intramolecular hydrogen bond. NMR studies show that both ligands are found as enol-imine tautomers in CDCl3 solution. In the solid state, the geometry around the copper(II) ion in both (C1) and (C2) is square planar. EPR spectra suggest that the geometry of the complexes is similar to that observed in the solid state by X-ray crystallography. Compound (C2) exhibited the strongest antiplatelet aggregation activity. Conclusion: Schiff base copper(II) complexes, which are attracting increasing interest, could represent a new approach to treat thrombosis by blocking the activity of PolyP with a potential anticoagulant activity and, most importantly, demonstrating no adverse bleeding events.

Copper(II) complexes with tridentate halogen‐substituted Schiff base ligands: synthesis, crystal structures and investigating the effect of halogenation, leaving group and ligand flexibility on antiproliferative activities

2021 ◽  
Author(s):  
Nazanin Kordestani ◽  
Hadi Amiri Rudbari ◽  
Alexandra R Fernandes ◽  
Luís R Raposo ◽  
André Luz ◽  
...  
Keyword(s):  
Schiff Base ◽  
Anticancer Activity ◽  
Crystal Structures ◽  
Copper Complexes ◽  
Schiff Base Ligands ◽  
Leaving Group ◽  
Leaving Groups ◽  
Tridentate Schiff Base ◽  
Antiproliferative Activities

To investigate the effect of different halogen substituents, leaving groups and the flexibility of ligand on the anticancer activity of copper complexes, sixteen copper(II) complexes with eight different tridentate Schiff-base...

scholarly journals Thermal and long period stability of series of V(V), V(IV) and V(III) complex with Schiff base ligands in solid state

2019 ◽  
Vol 4 (1) ◽  
pp. 30-36 ◽  
Author(s):  
Janusz Szklarzewicz ◽  
Anna Jurowska ◽  
Maciej Hodorowicz ◽  
Ryszard Gryboś
Keyword(s):  
Thermal Stability ◽  
Schiff Base ◽  
Solid State ◽  
Physicochemical Properties ◽  
General Formula ◽  
Oxidation State ◽  
Magnetic Moment ◽  
Tridentate Ligand ◽  
Schiff Base Ligands ◽  
Long Period

The synthesis and physicochemical properties of three new complexes of vanadium at +5, +4 and +3 oxidation state are described and discussed. The octahedral surrounding of vanadium for V(III) complexes of [V(L1)(HL1)] general formula is filled with two ONO tridentate ligand L, for V(IV) one ONO ligand L, oxido ligand and 1,10-phenanthroline (phen) as a co-ligand are presented in complexes of [VO(L2)(phen)]. For V(V) the complexes of [VO2(L1)(solv)] type were formed. As ligands, the H2L Schiff bases were formed in reaction between 5-hydroxysalcylaldehyde and phenylacetic hydrazide (H2L1) and 3,5-dichlorosalicyaldehyde and 4-hydroxybenzhydrazide (L2). The magnetic moment measurements, in 8 year period, show, that V(III) complexes slowly oxidise to V(IV) with preservation of the nonoxido character of the complexes, while V(IV) complexes were found to be stable. The TG and SDTA measurements indicate, that thermal stability depends mainly on the oxidation state of vanadium. The less thermally stable are the V(V) complexes, while V(IV) and V(III) are stable up to ca. 200oC. In solution, at pH 2 (similar to that in human digestion system), again the V(IV) are the most stable, only at pH 7.0 V(III) complexes had higher stability. The most stable, thus best for pharmaceutical use, are V(IV) complexes.

Syntheses, crystal structures, DNA binding, DNA cleavage and DFT study of Co(iii) complexes involving azo-appended Schiff base ligands

2018 ◽  
Vol 42 (20) ◽  
pp. 16571-16582 ◽  
Author(s):  
Saikat Banerjee ◽  
Roumi Patra ◽  
Pravat Ghorai ◽  
Paula Brandão ◽  
Sougata Ghosh Chowdhury ◽  
...  
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Crystal Structures ◽  
Dna Cleavage ◽  
Dft Study ◽  
Schiff Base Ligands

Herein, we have reported three new Co(iii) complexes involving azo-appended Schiff base ligands.

From solid state to in vitro anticancer activity of copper(ii) compounds with electronically-modulated NNO Schiff base ligands

2020 ◽  
Vol 49 (41) ◽  
pp. 14626-14639
Author(s):  
Luca Rigamonti ◽  
Francesco Reginato ◽  
Erika Ferrari ◽  
Laura Pigani ◽  
Lara Gigli ◽  
...  
Keyword(s):  
Schiff Base ◽  
Solid State ◽  
Anticancer Activity ◽  
Nitro Group ◽  
Schiff Base Ligands

The electron withdrawing nitro group enhances the in vitro cytotoxicity of copper(ii) complexes bearing tridentate NNO Schiff base ligands.

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