Structural diversity of lanthanide–amino acid complexes under near physiological pH conditions and their recognition of single-stranded DNA

Polyhedron ◽  
2007 ◽  
Vol 26 (18) ◽  
pp. 5250-5256 ◽  
Author(s):  
Hai-yuan Zhang ◽  
Hai-jia Yu ◽  
Hai-xia Xu ◽  
Jin-song Ren ◽  
Xiao-gang Qu
Keyword(s):  
Amino Acid ◽  
Structural Diversity ◽  
Single Stranded Dna ◽  
Amino Acid Complexes ◽  
Ph Conditions

Metal-, and Organocatalyst-Free One-Pot Assembly of Chiral Aza-Tricyclic Molecules: Creating Six Contiguous Stereocenters from 2-D-Structures and an Amino Acid

2020 ◽  
Author(s):  
Dung Do
Keyword(s):  
Amino Acid ◽  
Chemical Space ◽  
Structural Diversity ◽  
Therapeutic Agents ◽  
Chiral Molecules ◽  
One Pot ◽  
Complex Molecules ◽  
Chiral Catalyst ◽  
Chiral Complex ◽  
Free Process

<p>Chiral molecules with their defined 3-D structures are of paramount importance for the study of chemical biology and drug discovery. Having rich structural diversity and unique stereoisomerism, chiral molecules offer a large chemical space that can be explored for the design of new therapeutic agents.<sup>1</sup> Practically, chiral architectures are usually prepared from organometallic and organocatalytic processes where a transition metal or an organocatalyst is tailor-made for desired reactions. As a result, developing a method that enables rapid assembly of chiral complex molecules under metal- and organocatalyst-free condition represents a daunting challenge. Here we developed a straightforward route to create a chiral 3-D structure from 2-D structures and an amino acid without any chiral catalyst. The center of this research is the design of a <a>special chiral spiroimidazolidinone cyclohexadienone intermediate</a>, a merger of a chiral reactive substrate with multiple nucleophillic/electrophillic sites and a transient organocatalyst. <a>This unique substrate-catalyst (“subcatalyst”) dual role of the intermediate enhances </a><a>the coordinational proximity of the chiral substrate and catalyst</a> in the key Aza-Michael/Michael cascade resulting in a substantial steric discrimination and an excellent overall diastereoselectivity. Whereas the “subcatalyst” (hidden catalyst) is not present in the reaction’s initial components, which renders a chiral catalyst-free process, it is strategically produced to promote sequential self-catalyzed reactions. The success of this methodology will pave the way for many efficient preparations of chiral complex molecules and aid for the quest to create next generation of therapeutic agents.</p>

Potentiometric study of enantioselective effects in α-amino acid complexes of copper(II)

1985 ◽  
Vol 104 (1) ◽  
pp. 63-67 ◽  
Author(s):  
I.L. Ulanovski ◽  
A.A. Kurganov ◽  
V.A. Davankov
Keyword(s):  
Amino Acid ◽  
Potentiometric Study ◽  
Amino Acid Complexes

scholarly journals Synthesis, Characterization, and Non-Covalent Interactions of Palladium(II)-Amino Acid Complexes

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4331
Author(s):  
David B. Hobart ◽  
Michael A. G. Berg ◽  
Hannah M. Rogers ◽  
Joseph S. Merola
Keyword(s):  
Amino Acid ◽  
High Resolution Mass Spectrometry ◽  
Resonance Spectroscopy ◽  
Spectroscopic Techniques ◽  
X Ray Diffraction ◽  
Amino Acid Complexes ◽  
Acetone Water ◽  
Square Planar ◽  
Non Covalent Interactions ◽  
Covalent Interactions

The reaction of palladium(II) acetate with acyclic amino acids in acetone/water yields square planar bis-chelated palladium amino acid complexes that exhibit interesting non-covalent interactions. In all cases, complexes were examined by multiple spectroscopic techniques, especially HRMS (high resolution mass spectrometry), IR (infrared spectroscopy), and 1H NMR (nuclear magnetic resonance) spectroscopy. In some cases, suitable crystals for single crystal X-ray diffraction were able to be grown and the molecular structure was obtained. The molecular geometries of the products are discussed. Except for the alanine complex, all complexes incorporate water molecules into the extended lattice and exhibit N-H···O and/or O···(HOH)···O hydrogen bonding interactions. The non-covalent interactions are discussed in terms of the extended lattice structures exhibited by the structures.

Ternary chromium(III)-nucleotide-amino acid complexes III. L-Glutamic acid derivatives

1989 ◽  
Vol 165 (1) ◽  
pp. 131-137 ◽  
Author(s):  
M. Vicens ◽  
J.J. Fiol ◽  
A. Terron ◽  
V. Moreno
Keyword(s):  
Amino Acid ◽  
Glutamic Acid ◽  
Amino Acid Complexes ◽  
Glutamic Acid Derivatives

Equilibrium constants of metal amino acid complexes

Polyhedron ◽  
1990 ◽  
Vol 9 (5) ◽  
pp. 665-668 ◽  
Author(s):  
F. Rey ◽  
J.M. Antelo ◽  
F. Arce ◽  
F.J. Penedo
Keyword(s):  
Amino Acid ◽  
Equilibrium Constants ◽  
Amino Acid Complexes

Synthesis and properties of Zn(II)-salicylidene amino acid complexes

1987 ◽  
Vol 118 (11) ◽  
pp. 1289-1296 ◽  
Author(s):  
M. R. Mahmoud ◽  
S. A. El-Gyar ◽  
A. Shaker ◽  
A. M. Abdel-Mawgoud
Keyword(s):  
Amino Acid ◽  
Amino Acid Complexes

Fluoride-assisted stabilisation of amino acid complexes of vanadium Synthesis and characterisation

1996 ◽  
Vol 78 (2) ◽  
pp. 131-135 ◽  
Author(s):  
Mihir K. Chaudhuri ◽  
Shiv K. Chettri ◽  
Pradip C. Paul ◽  
Pendyala Srinivas
Keyword(s):  
Amino Acid ◽  
Amino Acid Complexes
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