scholarly journals Threshold changes in rat brain docosahexaenoic acid incorporation and concentration following graded reductions in dietary alpha-linolenic acid

2016 ◽  
Vol 105 ◽  
pp. 26-34 ◽  
Author(s):  
Ameer Y. Taha ◽  
Lisa Chang ◽  
Mei Chen
Keyword(s):  
Docosahexaenoic Acid ◽  
Rat Brain ◽  
Linolenic Acid ◽  
Alpha Linolenic Acid ◽  
Acid Incorporation

scholarly journals Effect of dietary docosahexaenoic acid on biosynthesis of docosahexaenoic acid from alpha-linolenic acid in young rats

2008 ◽  
Vol 49 (9) ◽  
pp. 1963-1980 ◽  
Author(s):  
James C. DeMar ◽  
Carmine DiMartino ◽  
Adam W. Baca ◽  
William Lefkowitz ◽  
Norman Salem
Keyword(s):  
Docosahexaenoic Acid ◽  
Linolenic Acid ◽  
Alpha Linolenic Acid ◽  
Young Rats ◽  
Dietary Docosahexaenoic Acid

scholarly journals Docosahexaenoic acid synthesis from α-linolenic acid by rat brain is unaffected by dietary n-3 PUFA deprivation

2007 ◽  
Vol 48 (5) ◽  
pp. 1150-1158 ◽  
Author(s):  
Miki Igarashi ◽  
James C. DeMar ◽  
Kaizong Ma ◽  
Lisa Chang ◽  
Jane M. Bell ◽  
...  
Keyword(s):  
Docosahexaenoic Acid ◽  
Rat Brain ◽  
Linolenic Acid ◽  
Acid Synthesis

scholarly journals Polyunsaturated fatty acids and risk of Alzheimer’s disease: a Mendelian randomization study

2019 ◽  
Vol 59 (4) ◽  
pp. 1763-1766 ◽  
Author(s):  
Yasutake Tomata ◽  
Susanna C. Larsson ◽  
Sara Hägg
Keyword(s):  
Fatty Acids ◽  
Arachidonic Acid ◽  
Linoleic Acid ◽  
Docosahexaenoic Acid ◽  
Polyunsaturated Fatty Acids ◽  
Eicosapentaenoic Acid ◽  
Linolenic Acid ◽  
Mendelian Randomization ◽  
Docosapentaenoic Acid ◽  
Alpha Linolenic Acid

Abstract Purpose Observational studies have suggested that polyunsaturated fatty acids (PUFAs) may decrease Alzheimer’s disease (AD) risk. In the present study, we examined this hypothesis using a Mendelian randomization analysis. Methods We used summary statistics data for single-nucleotide polymorphisms associated with plasma levels of n-6 PUFAs (linoleic acid, arachidonic acid) and n-3 PUFAs (alpha-linolenic acid, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid), and the corresponding data for AD from a genome-wide association meta-analysis of 63,926 individuals (21,982 diagnosed AD cases, 41,944 controls). Results None of the genetically predicted PUFAs was significantly associated with AD risk; odds ratios (95% confidence interval) per 1 SD increase in PUFA levels were 0.98 (0.93, 1.03) for linoleic acid, 1.01 (0.98, 1.05) for arachidonic acid, 0.96 (0.88, 1.06) for alpha-linolenic acid, 1.03 (0.93, 1.13) for eicosapentaenoic acid, 1.03 (0.97, 1.09) for docosapentaenoic acid, and 1.01 (0.81, 1.25) for docosahexaenoic acid. Conclusions This study did not support the hypothesis that PUFAs decrease AD risk.

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