Icosapent ethyl, a pure EPA omega-3 fatty acid: Effects on plasma and red blood cell fatty acids in patients with very high triglyceride levels (results from the MARINE study)

2013 ◽  
Vol 89 (4) ◽  
pp. 195-201 ◽  
Author(s):  
Rene A. Braeckman ◽  
Mehar S. Manku ◽  
Harold E. Bays ◽  
William G. Stirtan ◽  
Paresh N. Soni
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Icosapent Ethyl ◽  
Very High ◽  
High Triglyceride

Red blood cell omega-3 fatty acid levels and neurocognitive performance in deployed U.S. Servicemembers

2013 ◽  
Vol 16 (1) ◽  
pp. 30-38 ◽  
Author(s):  
Daniel T. Johnston ◽  
Patricia A. Deuster ◽  
William S. Harris ◽  
Holden MacRae ◽  
Michael N. Dretsch
Keyword(s):  
Fatty Acid ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Omega 3 ◽  
Neurocognitive Performance ◽  
Omega 3 Fatty Acid

Depletion of Omega-3 Fatty Acid Levels in Red Blood Cell Membranes of Depressive Patients

1998 ◽  
Vol 43 (5) ◽  
pp. 315-319 ◽  
Author(s):  
Malcolm Peet ◽  
Brendan Murphy ◽  
Janet Shay ◽  
David Horrobin
Keyword(s):  
Fatty Acid ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Membranes ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Red Blood Cell Membranes ◽  
Depressive Patients

scholarly journals Red Blood Cell Membrane Fatty Acids in U. S. Blood Donors (P06-123-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Carissa Powers ◽  
David Scully ◽  
Rosemary Schleicher
Keyword(s):  
Gender Differences ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Blood Donors ◽  
Saturated Fatty Acids ◽  
Omega 3 ◽  
Cardiac Events ◽  
Membrane Fatty Acids

Abstract Objectives The purpose of this study was to use a newly validated method for measuring 21 cis-fatty acids in red blood cell (RBC) membranes to investigate race-ethnic and gender differences in saturated fatty acids (SFA), monounsaturated fatty acids (MUFA), and polyunsaturated fatty acids (PUFA). In addition, two long-chain PUFA, namely, eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), were summed to provide an Omega-3 Index for each participant. This index is considered a cardiovascular risk factor. Methods Units (n = 120) of whole blood in EDTA were purchased from BioIVT (Westbury, NY). The demographic make-up of the set was 60:60 men: women. Of the 120 blood donors, 37% were black, 29% were white, and 34% were Hispanic. Average ages were 44 y (black), 48 y (white), and 43 y (Hispanic). Upon arrival, units were washed, treated with 1% BHT, and packed RBC were frozen until time of analysis. Hydrolysis of esters, derivitization with pentafluorobenzyl bromide, gas chromatography, and mass spectrometric detection were carried out to measure the 21 most abundant cis-fatty acid concentrations in RBC, which were converted to weight percentages of total. For the Omega-3 Index, the percentage of totals calculated for EPA and DHA were summed. Results There were few small (≤1%) race-ethnic differences and no gender differences in the proportions of fatty acids as SFA, MUFA, or PUFA; overall these averaged (SD) 44% (1%), 16% (1%), and 40% (1%), respectively. The Omega-3 Index averaged (SD) 3.5% (1%). One blood donor reached the suggested goal of ≥ 8%, which is associated with low risk for cardiac events. Conclusions This small study was undertaken in advance of the U.S. nationally representative survey, NHANES 2019–2020, in which RBC membrane fatty acids will be measured in the same laboratory. It will be interesting to learn whether NHANES will confirm the mostly null demographic findings in RBC fatty acid percentages and the low average Omega-3 Index. Funding Sources None.

scholarly journals Omega-3 fatty acid levels in red blood cell membranes and physical decline over 3 years: longitudinal data from the MAPT study

GeroScience ◽  
2017 ◽  
Vol 39 (4) ◽  
pp. 429-437 ◽  
Author(s):  
Bertrand Fougère ◽  
◽  
Sabine Goisser ◽  
Christelle Cantet ◽  
Gaëlle Soriano ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Blood Cell ◽  
Longitudinal Data ◽  
Red Blood Cell ◽  
Cell Membranes ◽  
Omega 3 ◽  
Physical Decline ◽  
Omega 3 Fatty Acid ◽  
Red Blood Cell Membranes

scholarly journals Relation Between Red Blood Cell Omega-3 Fatty Acid Index and Bleeding During Acute Myocardial Infarction

2012 ◽  
Vol 109 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Adam C. Salisbury ◽  
William S. Harris ◽  
Amit P. Amin ◽  
Kimberly J. Reid ◽  
James H. O'Keefe ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Fatty Acid ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Acid Index
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