Mechanisms for the effects of fish oil lipid emulsions in the management of parenteral nutrition-associated liver disease

2013 ◽  
Vol 89 (4) ◽  
pp. 153-158 ◽  
Author(s):  
P. Nandivada ◽  
E. Cowan ◽  
S.J. Carlson ◽  
M. Chang ◽  
K.M. Gura ◽  
...  
Keyword(s):  
Liver Disease ◽  
Parenteral Nutrition ◽  
Fish Oil ◽  
Lipid Emulsions

scholarly journals Influence of Fish Oil-Containing Lipid Emulsions on Parenteral Nutrition-Associated Liver Disease in Neonates

2017 ◽  
Vol 9 (1) ◽  
pp. 21-29
Author(s):  
Jeong-A Park ◽  
Ji-Eun Park ◽  
Min-Jae Jeong ◽  
Jae-Song Kim ◽  
Eun-Sun Son ◽  
...  
Keyword(s):  
Liver Disease ◽  
Parenteral Nutrition ◽  
Fish Oil ◽  
Lipid Emulsions

scholarly journals Fish Oil–Based Lipid Emulsions in the Treatment of Parenteral Nutrition-Associated Liver Disease: An Ongoing Positive Experience

2014 ◽  
Vol 5 (1) ◽  
pp. 65-70 ◽  
Author(s):  
Muralidhar H. Premkumar ◽  
Beth A. Carter ◽  
Keli M. Hawthorne ◽  
Kristi King ◽  
Steven A. Abrams
Keyword(s):  
Liver Disease ◽  
Parenteral Nutrition ◽  
Fish Oil ◽  
Lipid Emulsions ◽  
Positive Experience

scholarly journals Fish oil-based lipid emulsions versus standard lipid emulsions for prevention of parenteral nutrition-associated liver disease in children

2016 ◽  
Author(s):  
Juan Cristóbal Gana ◽  
Alex Castet ◽  
Luis A Villarroel del Pino ◽  
Lorena I Cifuentes ◽  
Romina Torres-Robles ◽  
...  
Keyword(s):  
Liver Disease ◽  
Parenteral Nutrition ◽  
Fish Oil ◽  
Lipid Emulsions

scholarly journals Fish oil-based lipid emulsions versus standard lipid emulsions for treatment of parenteral nutrition-associated liver disease in children

2016 ◽  
Author(s):  
Gigliola Alberti ◽  
Alex Castet ◽  
Luis A Villarroel del Pino ◽  
Lorena I Cifuentes ◽  
Marcela Rivera-Cornejo ◽  
...  
Keyword(s):  
Liver Disease ◽  
Parenteral Nutrition ◽  
Fish Oil ◽  
Lipid Emulsions

Fish Oil–Based Lipid Emulsions Prevent and Reverse Parenteral Nutrition–Associated Liver Disease: The Boston Experience

2009 ◽  
Vol 33 (5) ◽  
pp. 541-547 ◽  
Author(s):  
Vincent E. de Meijer ◽  
Kathleen M. Gura ◽  
Hau D. Le ◽  
Jonathan A. Meisel ◽  
Mark Puder
Keyword(s):  
Liver Disease ◽  
Parenteral Nutrition ◽  
Fish Oil ◽  
Lipid Emulsions

Parenteral Nutrition Associated Liver Toxicity: Prevention, Diagnosis and Management

2017 ◽  
Author(s):  
Meredith A. Baker ◽  
Lorenzo Anez-Bustillos ◽  
Duy T. Dao ◽  
Gillian L. Fell ◽  
Kathleen M. Gura ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Function ◽  
Parenteral Nutrition ◽  
Fish Oil ◽  
Liver Toxicity ◽  
Lipid Emulsions ◽  
Older Children ◽  
Key Factors ◽  
Prevention And Treatment

Long-term parenteral nutrition (PN) treatment is limited by parenteral nutrition–associated liver disease (PNALD), which is characterized initially by intrahepatic cholestasis, typically defined as a direct bilirubin greater than 2 mg/dL in the absence of other causes of liver disease. PNALD is typically less common and less severe and progresses more slowly in older children and adults than in infants. The etiology of PNALD is multifactorial. Key factors include immature liver function, sepsis, and a lack of enteral nutrition. Additionally, nearly every component of PN has been attributed to or exacerbated hepatotoxicity. PN preparations must be carefully individualized and monitored to minimize hepatotoxicity from its various components. Although many hepatotoxic components or imbalances have been recognized, soybean oil–based lipid emulsions continue to be widely used as they are the only lipid emulsions currently approved for PN by the Food and Drug Administration. Fish oil–based lipid emulsions have been shown to reverse PNALD, with an associated decrease in mortality. As such, fish oil therapy should be considered early once biochemical cholestasis is detected in PN-dependent patients. Studies investigating the use of novel lipid emulsions for prevention and treatment of PNALD are ongoing.   This review contains 5 figures, 5 tables, and  114 references.

Parenteral Nutrition Associated Liver Toxicity: Prevention, Diagnosis and Management

2017 ◽  
Author(s):  
Meredith A. Baker ◽  
Lorenzo Anez-Bustillos ◽  
Duy T. Dao ◽  
Gillian L. Fell ◽  
Kathleen M. Gura ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Function ◽  
Parenteral Nutrition ◽  
Fish Oil ◽  
Liver Toxicity ◽  
Lipid Emulsions ◽  
Older Children ◽  
Key Factors ◽  
Prevention And Treatment

Long-term parenteral nutrition (PN) treatment is limited by parenteral nutrition–associated liver disease (PNALD), which is characterized initially by intrahepatic cholestasis, typically defined as a direct bilirubin greater than 2 mg/dL in the absence of other causes of liver disease. PNALD is typically less common and less severe and progresses more slowly in older children and adults than in infants. The etiology of PNALD is multifactorial. Key factors include immature liver function, sepsis, and a lack of enteral nutrition. Additionally, nearly every component of PN has been attributed to or exacerbated hepatotoxicity. PN preparations must be carefully individualized and monitored to minimize hepatotoxicity from its various components. Although many hepatotoxic components or imbalances have been recognized, soybean oil–based lipid emulsions continue to be widely used as they are the only lipid emulsions currently approved for PN by the Food and Drug Administration. Fish oil–based lipid emulsions have been shown to reverse PNALD, with an associated decrease in mortality. As such, fish oil therapy should be considered early once biochemical cholestasis is detected in PN-dependent patients. Studies investigating the use of novel lipid emulsions for prevention and treatment of PNALD are ongoing.   This review contains 5 figures, 5 tables, and  114 references.

Mo1843 Parenteral Fish Oil Reverses Cholestasis in Parenteral Nutrition Associated Liver Disease

2013 ◽  
Vol 144 (5) ◽  
pp. S-1027
Author(s):  
Ryan Spurrier ◽  
Christa N. Grant ◽  
Pui Yuk Yan ◽  
Tracy Grikscheit ◽  
Russell Merritt
Keyword(s):  
Liver Disease ◽  
Parenteral Nutrition ◽  
Fish Oil
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