A case-control study between the gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and coronary artery disease in a Chinese Han population

2011 ◽  
Vol 85 (6) ◽  
pp. 329-333 ◽  
Author(s):  
Ling Qin ◽  
Lin Sun ◽  
Lin Ye ◽  
Jieping Shi ◽  
Liting Zhou ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Fatty Acids ◽  
Gene Polymorphisms ◽  
Case Control Study ◽  
Case Control ◽  
Chinese Han ◽  
Han Population ◽  
Artery Disease ◽  
Rate Limiting ◽  
Control Study

Role of SNPs of CPTIA and CROT genes in the carnitine-shuttle in coronary artery disease: a case-control study

2019 ◽  
Vol 44 (6) ◽  
pp. 822-830
Author(s):  
Aslihan Demircan ◽  
Ender Coskunpinar ◽  
Deniz Kanca ◽  
Gulcin Ozkara ◽  
Fatih Yanar ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Fatty Acids ◽  
Case Control Study ◽  
Threshold Value ◽  
Case Control ◽  
Long Chain Fatty Acids ◽  
Artery Disease ◽  
Control Study ◽  
Long Chain

Abstract Objective Fatty acid β-oxidation defects can lead to difficulties at covering energy requirement of heart. The carnitine-shuttle is responsible for the transfering of long-chain fatty acids from the internal mitochondrial membrane. The role of genetic variants of the enzymes in the carnitine shuttle in coronary artery disease (CAD) has not been studied. Therefore, we performed a case-control study investigating the possible relation between the CPTIA-rs3019613 and CROT-rs2214930 gene variations located carnitine shuttle and CAD risk. Materials and methods Study groups were comprised of 96 CAD patients and 85 controls. CPTIA-rs3019613 G > A and CROT-rs2214930 T > C polymorphisms were determined by real-time-PCR. Results The CROT-rs2214930-CC genotype was found to be associated with decreased HDL-cholesterol (HDL-C) in controls (p = 0.029). In patients with CPTIA-rs3019613-A allele, body mass index (BMI) (p = 0.016) and BMI threshold-value (p = 0.030) were found be higher compared to those with GG-genotype, while HDL-C threshold-value (HDL-C ≤ 0.90 mmol/L) was found to be lower (p = 0.015). Regression analysis confirmed CPTIA-rs3019613-A allele has a significant relationship with decreased HDL-C (p = 0.009) in patients. Conclusion Our study indicated that the polymorphisms of the CROT and CPTIA genes related to β-oxidation of long-chain fatty acids had an important effect on serum HDL-C levels and may be a potential risk for CAD.

Association of MTHFR, IL-6 and ICAM-1 gene Polymorphisms with Coronary Artery Disease in South-Indian Ethnic Subset: A Case-Control Study

2018 ◽  
Vol 9 (3) ◽  
pp. 115-122 ◽  
Author(s):  
Latheef Latheef K ◽  
Rajasekhar Rajasekhar D ◽  
Vanajakshamma Vanajakshamma V ◽  
Aparna Aparna BR ◽  
Chaudhury Chaudhury A ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Polymorphisms ◽  
Case Control Study ◽  
Case Control ◽  
South Indian ◽  
Artery Disease ◽  
Control Study
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