scholarly journals Associations of maternal prenatal dietary intake of n-3 and n-6 fatty acids with maternal and umbilical cord blood levels

2009 ◽  
Vol 80 (5-6) ◽  
pp. 289-296 ◽  
Author(s):  
S.M.A. Donahue ◽  
S.L. Rifas-Shiman ◽  
S.F. Olsen ◽  
D.R. Gold ◽  
M.W. Gillman ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Dietary Intake ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Levels

scholarly journals Quantification of Lutein + Zeaxanthin Presence in Human Placenta and Correlations with Blood Levels and Maternal Dietary Intake

Nutrients ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 134 ◽  
Author(s):  
Melissa Thoene ◽  
Ann Anderson-Berry ◽  
Matthew Van Ormer ◽  
Jeremy Furtado ◽  
Ghada Soliman ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Human Placenta ◽  
Birth Outcome ◽  
Maternal Serum ◽  
Blood Levels ◽  
Cross Sectional ◽  
Maternal Dietary Intake

Lutein + zeaxanthin (L + Z) are carotenoids recognized in eye health, but less is known about their status during pregnancy. While quantified in maternal and umbilical cord blood, they have never been analyzed in placenta. The purpose of this study is to quantify combined L + Z concentrations in human placenta and correlate with levels in maternal dietary intake, maternal serum, and umbilical cord blood. The proportions of combined L + Z were compared within diet, placenta, maternal serum, and umbilical cord blood among additional carotenoids (lycopene, β-cryptoxanthin, α-carotene, and β-carotene). This Institutional Review Boardapproved cross-sectional study enrolled 82 mother-infant pairs. Placenta, maternal serum, and umbilical cord blood samples were analyzed for carotenoids concentrations. Mothers completed a food frequency questionnaire and demographic/birth outcome data were collected. L + Z were present in placenta, median 0.105 micrograms/gram (mcg/g) and were significantly correlated with maternal serum (r = 0.57; p < 0.001), umbilical cord blood levels (r = 0.49; p = 0.001), but not dietary intake (p = 0.110). L + Z were the most prevalent in placenta (49.1%) umbilical cord blood (37.0%), but not maternal serum (18.6%) or dietary intake (19.4%). Rate of transfer was 16.0%, the highest of all carotenoids. Conclusively, L + Z were identified as the two most prevalent in placenta. Results highlight unique roles L + Z may play during pregnancy.

scholarly journals Maternal and umbilical cord blood levels of mercury, manganese, iron, and copper in southern Taiwan: A cross-sectional study

2017 ◽  
Vol 80 (7) ◽  
pp. 442-451 ◽  
Author(s):  
Shih-Hui Huang ◽  
Ken-Pen Weng ◽  
Ching-Chiang Lin ◽  
Chung-Cheng Wang ◽  
Charles Tzu-Chi Lee ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Cross Sectional Study ◽  
Blood Levels ◽  
Sectional Study ◽  
Cross Sectional ◽  
Southern Taiwan

Umbilical cord blood levels of perfluoroalkyl acids and polybrominated flame retardants

2013 ◽  
Vol 216 (2) ◽  
pp. 184-194 ◽  
Author(s):  
Tye E. Arbuckle ◽  
Cariton Kubwabo ◽  
Mark Walker ◽  
Karelyn Davis ◽  
Kaela Lalonde ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Flame Retardants ◽  
Perfluoroalkyl Acids ◽  
Blood Levels

Maternal and Umbilical Cord Blood Levels of Arsenic, Cadmium, Manganese, and Lead in Rural Bangladesh

Epidemiology ◽  
2009 ◽  
Vol 20 ◽  
pp. S149-S150 ◽  
Author(s):  
Molly Kile ◽  
Robert Wright ◽  
Chitra Amarasiriwardena ◽  
Quazi Quamruzzaman ◽  
Mahmuder Rahman ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Levels ◽  
Rural Bangladesh

GLYCOSYLATED FIBRONECTIN AND INHIBIN ARE LOWER AND ANTI-MÜLLERIAN HORMONE IS HIGHER IN UMBILICAL CORD BLOOD WHEN MOTHERS HAVE PREECLAMPSIA

2020 ◽  
Vol 26 (3) ◽  
pp. 318-327
Author(s):  
Bridget DiPrisco ◽  
Ajay Kumar ◽  
Bhanu Kalra ◽  
Gopal V. Savjani ◽  
Zoe Michael ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Immunosorbent Assay ◽  
Plasma Protein ◽  
Umbilical Cord Blood ◽  
Enzyme Linked Immunosorbent Assay ◽  
Blood Levels ◽  
Insulin Like Growth Factor ◽  
Tertiary Teaching

Objective: Preeclampsia is a common disorder of pregnancy, causing significant morbidity and mortality for mothers and infants. Several molecules, including glycosylated fibronectin (GlyFn), the inhibin-related proteins, anti-müllerian hormone (AMH), and the insulin-like growth factor axis, are altered in maternal plasma in the setting of preeclampsia; however, these molecules have not been previously measured in cord blood of infants born to mothers with preeclampsia, which may represent changes in fetal physiology. We evaluated potential biomarkers of preeclampsia in umbilical cord blood to fill the gap in knowledge. Methods: This is a case-control study of 196 neonates born at a tertiary teaching hospital in Boston from 2010–2017. Forty-nine neonates born to mothers with preeclampsia were matched 1:3 by gestational age, sex, and birth weight z-score with 147 controls. Eleven analytes were measured in cord blood by enzyme-linked immunosorbent assay. Binary logistic regression analyses were performed to evaluate associations between preeclampsia and analytes. Results: Mean cord blood levels of GlyFn and total inhibin were significantly lower in neonates born to mothers with preeclampsia compared to controls, and AMH levels were significantly higher in males born to mothers with preeclampsia than male controls. Associations remained significant after controlling for maternal and neonatal characteristics. Conclusion: Cord blood levels of GlyFn and inhibin are decreased and AMH (male) levels are increased in infants of preeclamptic mothers, which is opposite the pattern these biomarkers show in serum of mothers with preeclampsia. These molecules may be important in the pathophysiology and long-term effects of preeclampsia on the developing fetus. Abbreviations: AMH = anti-müllerian hormone; ELISA = enzyme-linked immunosorbent assay; GlyFn = glycosylated fibronectin; IGF = insulin-like growth factor; IGFBP5 = insulin-like growth factor binding protein 5; LOD = limit of detection; PAPP-A = pregnancy-associated plasma protein A; PAPP-A2 = pregnancy-associated plasma protein A2

scholarly journals Umbilical cord blood levels of maternal antibodies reactive with p200 and full-length Ro 52 in the assessment of risk for cardiac manifestations of neonatal lupus

2012 ◽  
Vol 64 (9) ◽  
pp. 1373-1381 ◽  
Author(s):  
Joanne H. Reed ◽  
Robert M. Clancy ◽  
Kristen H. Lee ◽  
Amit Saxena ◽  
Peter M. Izmirly ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Full Length ◽  
Maternal Antibodies ◽  
Blood Levels ◽  
Neonatal Lupus ◽  
Cardiac Manifestations

Are postnatal ampicillin levels actually related to the duration of intrapartum antibiotic prophylaxis prior to delivery? A pharmacokinetic study in 120 neonates

2017 ◽  
Vol 103 (2) ◽  
pp. F152-F156 ◽  
Author(s):  
Alberto Berardi ◽  
Zaira Pietrangiolillo ◽  
Maria Letizia Bacchi Reggiani ◽  
Valentina Bianco ◽  
Daniela Gallesi ◽  
...  
Keyword(s):  
Antibiotic Prophylaxis ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Peripheral Blood ◽  
Blood Levels ◽  
Loading Dose ◽  
Intrapartum Antibiotic Prophylaxis ◽  
Intrapartum Antibiotic ◽  
Full Loading

ObjectiveTo assess ampicillin levels according to the duration of intrapartum antibiotic prophylaxis (IAP).DesignProspective cohort single-centre study.SettingTertiary care centre (Modena, Italy).Patients120 neonates≥35 weeks’ gestation exposed to IAP.InterventionsNeonates were divided into four groups, according to the duration of IAP prior to delivery: group 1 (n=30; <1 hour), group 2 (n=30; ≥1 and <2 hours), group 3 (n=30; ≥2 and <4 hours) and group 4 (n=30; ≥2 doses, ≥4 hours).Main outcome measuresBlood samples were collected at delivery (from the umbilical cord) and at age 4 hours (from a peripheral vessel).ResultsMedian duration of IAP was 121 min (range 7–2045 min). Median ampicillin levels in umbilical cord blood were 10.4 µg/mL (IQR 6.4–14.9) and in peripheral blood were 4.7 µg/mL (IQR 2.8–6.4µg/mL). Umbilical cord blood levels reached a peak approximately 30 min after IAP and then declined significantly (p<0.001). Peripheral blood levels did not differ among study groups. Neonates exposed to a full loading dose (n=115) had peripheral blood levels 2.5–70 times higher than the minimal inhibitory concentration for group B streptococcus. There was no relationship between neonatal ampicillin concentrations and the duration of IAP prior to delivery (β=−0.0003, 95% CI −0.02 to 0.001, p=0.680).ConclusionsAmpicillin levels reach a peak in the umbilical cord blood within 30 min of intrapartum administration. After a full loading dose, bactericidal levels persist for at least 4 hours after birth and seem independent of the duration of IAP prior to delivery.

Maternal and umbilical cord blood levels of mercury, lead, cadmium, and essential trace elements in Arctic Canada

2006 ◽  
Vol 100 (3) ◽  
pp. 295-318 ◽  
Author(s):  
Jody Butler Walker ◽  
Jan Houseman ◽  
Laura Seddon ◽  
Ed McMullen ◽  
Karen Tofflemire ◽  
...  
Keyword(s):  
Trace Elements ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Levels ◽  
Arctic Canada ◽  
Essential Trace Elements
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