Platelet phospholipid n−3 PUFA negatively associated with plasma homocysteine in middle-aged and geriatric hyperlipaemia patients

2007 ◽  
Vol 76 (5) ◽  
pp. 293-297 ◽  
Author(s):  
D. Li ◽  
X.M. Yu ◽  
H.B. Xie ◽  
Y.H. Zhang ◽  
Q. Wang ◽  
...  
Keyword(s):  
Plasma Homocysteine ◽  
Platelet Phospholipid ◽  
Middle Aged ◽  
Negatively Associated

scholarly journals Inflamm-Aging Is Associated with Lower Plasma PTX3 Concentrations and an Impaired Capacity of PBMCs to Express hTERT following LPS Stimulation

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Aaron L. Slusher ◽  
Tiffany M. Zúñiga ◽  
Edmund O. Acevedo
Keyword(s):  
Gene Expression ◽  
Young Adults ◽  
Telomere Length ◽  
Immune Cell ◽  
Ex Vivo ◽  
Middle Aged ◽  
Human Telomerase Reverse Transcriptase ◽  
Negatively Associated ◽  
Htert Gene ◽  
Age Related

Age-related elevations in proinflammatory cytokines, known as inflamm-aging, are associated with shorter immune cell telomere lengths. Purpose. This study examined the relationship of plasma PTX3 concentrations, a biomarker of appropriate immune function, with telomere length in 15 middle-aged (40-64 years) and 15 young adults (20-31 years). In addition, PBMCs were isolated from middle-aged and young adults to examine their capacity to express a key mechanistic component of telomere length maintenance, human telomerase reverse transcriptase (hTERT), following ex vivo cellular stimulation. Methods. Plasma PTX3 and inflammatory cytokines (i.e., IL-6, IL-10, TGF-β, and TNF-α), PBMC telomere lengths, and PBMC hTERT gene expression and inflammatory protein secretion following exposure to LPS, PTX3, and PTX3+LPS were measured. Results. Aging was accompanied by the accumulation of centrally located visceral adipose tissue, without changes in body weight and BMI, and alterations in the systemic inflammatory milieu (decreased plasma PTX3 and TGF-β; increased TNF-α (p≤0.050)). In addition, shorter telomere lengths in middle-aged compared to young adults (p=0.011) were negatively associated with age, body fat percentages, and plasma TNF-α (r=−0.404, p=0.027; r=−0.427, p=0.019; and r=−0.323, p=0.041, respectively). Finally, the capacity of PBMCs to increase hTERT gene expression following ex vivo stimulation was impaired in middle-aged compared to young adults (p=0.033) and negatively associated with telomere lengths (r=0.353, p=0.028). Conclusions. Proinflammation and the impaired hTERT gene expression capacity of PBMCs may contribute to age-related telomere attrition and disease.

scholarly journals Association of Childhood Socioeconomic Status with Edentulism Among Chinese Middle-aged Adults

2019 ◽  
Author(s):  
XIAONING ZHANG ◽  
SHUANG CHEN
Keyword(s):  
Socioeconomic Status ◽  
Directed Acyclic Graphs ◽  
Adult Health ◽  
Middle Aged ◽  
Childhood Health ◽  
Negatively Associated ◽  
Drinking Habits ◽  
Health Related Behaviors ◽  
Health Related ◽  
Childhood Socioeconomic Status

Abstract Objectives The purpose of this study was to examine the association between childhood socioeconomic status (SES) and edentulism using directed acyclic graphs (DAGs) for the selection of confounders, and after adjusting for childhood health, adult SES, adult health-related behaviors and father’s health-related behaviors. Methods Chinese respondents in a Health and Retirement Longitudinal Study (CHARLS) were assessed at age 45 and 59 years. Childhood SES was determined using the father’s education, parents’ occupation, father’s working status, family’s financial situation, self-perceived childhood health, relationship with the father, mother’s effort to care for her child, mother’s love and affection, parents quarrel and fight, residential community safety, primary residence, neighbors’ help, neighborhood relation, enough food availability and access to medical care and convenience. Father’ health-related behaviors were established by taking into account smoking and drinking habits. Childhood health was determined by considering childhood hospitalization and self-perceived childhood health status. Adult SES was established based on adulthood educational achievements. Adult health-related behaviors were determined by taking into account smoking and drinking habits, as well as physical activities and sleep time. Edentulism was determined using self-reported lost all of teeth. The mediators were selected using DAGs, cross-tabulation and binary logistic regression models based on DAGs. Model assessment of the regression equation was evaluated by Hosmer-Lemeshow goodness-of-fit test. Results Data from a total of 7,459 respondents were available, 140 of whom were edentulous (1.9%). The prevalence of edentulism at ages 45 and 59 years was substantially higher among those with low childhood SES. In all adjusted models based on DAGs, edentulism was negatively associated with father’s occupation as farmer (OR = 5.7, 95% CI = 1.3–25.0) and neighbor’s unwillingness to help (OR = 4.9, 95% CI = 1.6–15.4). Conclusion Childhood SES was associated with the prevalence of edentulism among middle-aged Chinese adults, whereas the father’s occupation, and neighbor’s help were negatively associated with edentulism. The experiences in early life associated with low SES contributes to poor dental health. Therefore, more attention needs to be paid to childhood SES in order to determine optimal recommendations and develop more effective intervention strategies.

scholarly journals Moderating Effects of Loneliness on COVID-19-Related Stress and Anxiety in Middle and Later Life in South Korea

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 141-141
Author(s):  
Sukyung Yoon ◽  
Soo Chan Choi
Keyword(s):  
Older Adults ◽  
South Korea ◽  
Living Arrangements ◽  
Service Providers ◽  
Later Life ◽  
Moderating Effects ◽  
Middle Aged ◽  
Negatively Associated ◽  
Related Stress ◽  
The Impact

Abstract Many people have suffered from psychological distress in the form of stress, loneliness, and anxiety resulting from the COVID-19 epidemic (Havnen et al., 2020; Luchetti et al., 2020). Along with these factors, physical health (hereafter health), resilience, and living arrangements as protective factors were examined. The research aims were to investigate 1) factors affecting the association between COVID-19-related stress (hereafter stress) and anxiety, and 2) moderating effects of loneliness on this association. Data was collected on 450 middle-aged and older adults (ages 45 through 76) living in South Korea during COVID-19. A multi-group path analysis was employed. Measurement invariance was examined by comparing unconstrained and fully constrained models. Both models fit. Moderating effects of loneliness existed. Stress was negatively associated with health and living arrangements for people with both higher and lower levels of loneliness. Health was positively associated with resilience for both groups. Resilience was negatively associated with anxiety for both groups. For people with higher levels of loneliness only, stress and health were negatively associated with resilience and anxiety, respectively. The association between stress and anxiety was significant for both groups. However, the impact of stress on anxiety was significantly larger for people with higher levels of loneliness than for people with lower levels of loneliness. Health practitioners and service providers should develop programs to maintain and promote resilience, social support, and good health among middle-aged and older adults in South Korea to mitigate negative mental health consequences during the pandemic.

Association of Baseline Knee Bone Size, Cartilage Volume, and Body Mass Index with Knee Cartilage Loss Over Time: A Longitudinal Study in Younger or Middle-aged Adults

2011 ◽  
Vol 38 (9) ◽  
pp. 1973-1980 ◽  
Author(s):  
BENNY ANTONY ◽  
CHANGHAI DING ◽  
OLIVER STANNUS ◽  
FLAVIA CICUTTINI ◽  
GRAEME JONES
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Cartilage Volume ◽  
Bone Size ◽  
Cartilage Loss ◽  
Annual Change ◽  
Knee Cartilage ◽  
Middle Aged ◽  
Negatively Associated ◽  
Middle Aged Adults

Objective.To determine the association of knee bone size, cartilage volume, and body mass index (BMI) at baseline with knee cartilage loss over 2 years in younger or middle-aged adults.Methods.A total of 324 subjects (mean age 45 yrs, range 26–61) were measured at baseline and about 2 years later. Knee cartilage volume and bone size were determined using T1-weighted fat-saturated magnetic resonance imaging.Results.In multivariable analysis, baseline knee bone size was negatively associated with annual change in knee cartilage volume at medial and lateral tibial sites (ß = −0.62% to −0.47%/cm2, all p < 0.001). The associations disappeared at medial tibial site after adjustment for baseline cartilage volume and became of borderline statistical significance at lateral tibial site after adjustment for both baseline cartilage volume and osteophytes (ß = −0.29, p = 0.059). Baseline knee cartilage volume was consistently and negatively associated with annual change in knee cartilage volume at all 3 medial tibial, lateral tibial, and patellar sites (ß = −4.41% to −1.37%/ml, all p < 0.001). Baseline BMI was negatively associated with an annual change in knee cartilage volume, but only in subjects within the upper tertile of baseline cartilage volume, even after adjusting for cartilage defects (ß = −0.16% to −0.34%/kg/m2, all p < 0.05).Conclusion.Our study suggests that both higher baseline tibial bone area and knee cartilage volume (most likely due to cartilage swelling) are associated with greater knee cartilage loss over 2 years. A higher BMI was associated with greater knee cartilage loss only in subjects with higher baseline cartilage volume.

scholarly journals The Association between Omega-3 Fatty Acid Intake and Human Brain Connectivity in Middle-Aged Depressed Women

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2191
Author(s):  
Seon-Joo Park ◽  
Do-Kyung Lee ◽  
Bokyoung Kim ◽  
Kyoung-Sae Na ◽  
Chang-Ho Lee ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Fatty Acid ◽  
Functional Connectivity ◽  
Depression Scale ◽  
Omega 3 ◽  
Middle Aged ◽  
Negatively Associated ◽  
Omega 3 Fatty Acid ◽  
The Right ◽  
Brain Functional Connectivity

Omega-3 fatty acid (n-3 FA) intake is known to have a preventive effect on depressive symptoms in a general population. This study assessed the effects of n-3 FA intake on depressive symptoms and brain function in middle-aged women. Depressive symptoms were screened using the Beck Depression Inventory-II (BDI-II) and Center for Epidemiologic Studies-Depression scale (CES-D) assessment questionnaires, and n-3 FA intakes were assessed using semiquantitative food frequency questionnaire. We found that n-3 FA intakes were negatively associated with depressive symptoms in middle-aged women. Psychiatrists diagnosed the presence of depressive disorders using the 5th edition of the Mental Disorder Diagnosis and Statistics Manual (DSM-5). Resting-state functional magnetic resonance imaging (rs-fMRI) was performed to investigate the association between n-3 FA intake and brain functional connectivity. Functional connectivity of the right middle frontal cortex (default mode network) and the right middle temporal pole (frontoparietal network) was positively associated with depressive symptom scores and negatively associated with n-3 FA intakes. In conclusion, high n-3 FA intake decreases the risk of depressive symptoms and modifies the brain functional connectivity in middle-aged women.

scholarly journals Serum sex hormone and plasma homocysteine levels in middle-aged and elderly men

2006 ◽  
Vol 155 (6) ◽  
pp. 887-893 ◽  
Author(s):  
Hamid Reza Nakhai Pour ◽  
Diederick E Grobbee ◽  
Majon Muller ◽  
Marielle Emmelot-Vonk ◽  
Yvonne T van der Schouw
Keyword(s):  
Creatinine Clearance ◽  
Visceral Fat ◽  
Linear Regression Analysis ◽  
Plasma Homocysteine ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Middle Aged ◽  
Elderly Men ◽  
Fasting Plasma

Objective: To investigate whether circulating levels of testosterone (total, bioavailable), estradiol (total, bioavailable), and DHEA sulfate (DHEAS) are associated with fasting plasma homocysteine (tHcy) levels in middle-aged and elderly men. Design: A population-based sample of 400 independently living men between 40 and 80 years of age in a cross-sectional study. Methods: Total testosterone, sex hormone binding globulin (SHBG), and total estradiol were measured by RIA methods and bioavailable testosterone and estradiol were calculated. DHEAS was measured using an immunometric technique. Fasting homocysteine was measured by fluorescence polarization immunoassay. Anthropometric characteristics were also measured and two standardized questionnaires completed, including life-style factors and diet. Linear regression analysis adjusted for age, body mass index (BMI), creatinine clearance, and mean visceral fat was used to assess the association of endogenous sex hormones and fasting plasma homocysteine levels. Results: After adjustment for age, BMI, creatinine clearance, and mean visceral fat no statistically significant association was observed between testosterone (total, bioavailable), DHEAS, and estradiol (total, bioavailable)levels with natural log tHcy (β = −2 × 10−3; 95% confidence intervals (CI) −9 × 10−3; 5 × 10−3), (β = −4 × 10−3; 95% CI −18 × 10−3; 9 × 10−3), (β = 3 × 10−3; 95% CI −6 × 10−3; 12 × 10−3), (β = −9.3 × 10−5; 95% CI −1 × 10−3; 1 × 10−3), and (β = 0.00; 95% CI −3 × 10−3; 2 × 10−3) respectively. Additional adjustment for smoking, alcohol intake, daily physical activity, diabetes mellitus, and hypertension did not change these findings. Conclusion: The results of our study do not support a direct role for circulating sex hormone levels in the regulation of fasting plasma tHcy concentrations in middle-aged and elderly men.

scholarly journals Influence of bone remodelling rate on quantitative ultrasound parameters at the calcaneus and DXA BMDa of the hip and spine in middle-aged and elderly European men: the European Male Ageing Study (EMAS)

2011 ◽  
Vol 165 (6) ◽  
pp. 977-986 ◽  
Author(s):  
Steven Boonen ◽  
Stephen R Pye ◽  
Terence W O'Neill ◽  
Pawel Szulc ◽  
Evelien Gielen ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Bone Turnover ◽  
Quantitative Ultrasound ◽  
Bone Health ◽  
Bone Markers ◽  
Bone Remodelling ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Middle Aged ◽  
Negatively Associated

ObjectiveTo assess the influence of sex hormones on markers of bone turnover and to explore the association between these markers and bone health in middle-aged and elderly European men.DesignA cross-sectional population-based survey.MethodsMen aged 40–79 years were recruited from population registers in eight European centres. Subjects completed a postal questionnaire which included questions concerning lifestyle and were invited to undergo quantitative ultrasound (QUS) of the calcaneus and to provide a fasting blood sample from which the bone markers serum N-terminal propeptide of type 1 procollagen (P1NP) and crosslinks (β C-terminal cross-linked telopeptide (β-cTX)), total testosterone, total oestradiol (E2), sex hormone-binding globulin (SHBG) and insulin-like growth factor 1 (IGF1) were measured. Dual-energy X-ray absorptiometry (DXA) of the hip and lumbar spine was performed in two centres.ResultsA total of 3120, mean age 59.9 years (s.d.=11.0) were included. After adjustment for centre, age, height, weight, lifestyle factors, season and other hormones, total and free E2were negatively associated with β-cTX but not P1NP while SHBG, IGF1 and parathyroid hormone (PTH) were positively associated with both β-cTX and P1NP. Total or free testosterone was not independently associated with either bone marker. After the same adjustments, higher levels of both bone markers were significantly associated with lower QUS parameters and lower DXA-assessed bone density at the total hip and lumbar spine.ConclusionsE2, SHBG, IGF1 and PTH contribute significantly to the regulation/rate of bone turnover in middle-aged and older European men. Higher rates of bone remodelling are negatively associated with male bone health.

scholarly journals Associations of plasma phospholipid fatty acids with plasma homocysteine in Chinese vegetarians

2012 ◽  
Vol 109 (9) ◽  
pp. 1688-1694 ◽  
Author(s):  
Tao Huang ◽  
Xiaomei Yu ◽  
Tianxing Shou ◽  
Mark L. Wahlqvist ◽  
Duo Li
Keyword(s):  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Plasma Phospholipid ◽  
Plasma Homocysteine ◽  
Fatty Acid Status ◽  
Standard Methods ◽  
Negatively Associated ◽  
Acid Status ◽  
Total Pufa

The association of plasma phospholipid (PL) fatty acid composition with plasma homocysteine (Hcy) in Chinese vegetarians is not understood. The main aim of the present study was to investigate the plasma PL fatty acid status, and its association with plasma Hcy in Chinese vegetarians and omnivores. A total of 103 male vegetarians and 128 male omnivores were recruited in Linyin Temple, Hangzhou. Plasma Hcy and PL fatty acid concentrations were determined by standard methods. Compared with omnivores, plasma PL n-3 PUFA (P< 0·001), 22 : 6n-3 (P< 0·001), 22 : 5n-6 (P= 0·021), 22 : 2n-6 (P< 0·001) and SFA (P= 0·017) were significantly lower, while plasma PL n-6 PUFA (P= 0·007) and total PUFA (P< 0·001) were significantly higher in vegetarians. The prevalence of hyperhomocysteinaemia (HHcy) in vegetarians (26·47 %) was significantly higher than that in omnivores (13·28 %). In vegetarians, plasma PL 22 : 6n-3 (r − 0·257, P= 0·046) was significantly negatively associated with plasma Hcy. In omnivores, plasma PL 18 : 1n-7 (r 0·237, P= 0·030) was significantly positively associated with plasma Hcy. Plasma PL 22 : 6n-3 (r − 0·217, P= 0·048) was negatively associated with plasma Hcy in omnivores. Plasma PL SFA were positively associated with the prevalence of HHcy. It would seem appropriate for vegetarians to increase their dietary n-3 PUFA and decrease dietary SFA, and thus reduce the risk of HHcy.

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