scholarly journals Sequential induction of pro- and anti-inflammatory prostaglandins and peroxisome proliferators-activated receptor-gamma during normal wound healing: A time course study

2007 ◽  
Vol 76 (2) ◽  
pp. 103-112 ◽  
Author(s):  
Mohit Kapoor ◽  
Fumiaki Kojima ◽  
Lihua Yang ◽  
Leslie J. Crofford
Keyword(s):  
Wound Healing ◽  
Time Course ◽  
Peroxisome Proliferators ◽  
Normal Wound Healing ◽  
Anti Inflammatory ◽  
Time Course Study ◽  
Sequential Induction

scholarly journals Hypoxia impairs mesenchymal stromal cell-induced macrophage M1 to M2 transition

TECHNOLOGY ◽  
2017 ◽  
Vol 05 (02) ◽  
pp. 81-86 ◽  
Author(s):  
Renea A. Faulknor ◽  
Melissa A. Olekson ◽  
Emmanuel C. Ekwueme ◽  
Paulina Krzyszczyk ◽  
Joseph W. Freeman ◽  
...  
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Interleukin 10 ◽  
M2 Macrophage ◽  
Therapeutic Effects ◽  
M1 Macrophages ◽  
Normal Wound Healing ◽  
Hypoxic Environment ◽  
Anti Inflammatory ◽  
M2 Phenotype

The transition of macrophages from the pro-inflammatory M1 to the anti-inflammatory M2 phenotype is crucial for the progression of normal wound healing. Persistent M1 macrophages within the injury site may lead to an uncontrolled macrophage-mediated inflammatory response and ultimately a failure of the wound healing cascade, leading to chronic wounds. Mesenchymal stromal cells (MSCs) have been widely reported to promote M1 to M2 macrophage transition; however, it is unclear whether MSCs can drive this transition in the hypoxic environment typically observed in chronic wounds. Here we report on the effect of hypoxia (1% O[Formula: see text] on MSCs’ ability to transition macrophages from the M1 to the M2 phenotype. While hypoxia had no effect on MSC secretion, it inhibited MSC-induced M1 to M2 macrophage transition, and suppressed macrophage expression and production of the anti-inflammatory mediator interleukin-10 (IL-10). These results suggest that hypoxic environments may impede the therapeutic effects of MSCs.

PDGF supplementation alters oxidative events in wound healing process: a time course study

2013 ◽  
Vol 305 (5) ◽  
pp. 415-422 ◽  
Author(s):  
Kaan Kaltalioglu ◽  
Sule Coskun-Cevher ◽  
Fatmanur Tugcu-Demiroz ◽  
Nevin Celebi
Keyword(s):  
Wound Healing ◽  
Time Course ◽  
Healing Process ◽  
Wound Healing Process ◽  
Time Course Study

scholarly journals Time course study of delayed wound healing in a biofilm-challenged diabetic mouse model

2012 ◽  
Vol 20 (3) ◽  
pp. 342-352 ◽  
Author(s):  
Ge Zhao ◽  
Marcia L. Usui ◽  
Robert A. Underwood ◽  
Pradeep K. Singh ◽  
Garth A. James ◽  
...  
Keyword(s):  
Wound Healing ◽  
Mouse Model ◽  
Time Course ◽  
Diabetic Mouse ◽  
Delayed Wound Healing ◽  
Time Course Study

scholarly journals Time-Course Study of Gastric Damages in Rats by Anti-Inflammatory Drugs Using a Gastroscope and Its Quantification

1988 ◽  
Vol 48 (3) ◽  
pp. 317-322 ◽  
Author(s):  
Akira FUJII ◽  
Noboru KUBOYAMA ◽  
Sumi KOBAYASHI ◽  
Yoshikazu NAMIKI ◽  
Toyoyuki TAMURA
Keyword(s):  
Time Course ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Time Course Study

scholarly journals Nonsteroidal Anti-Inflammatory Drugs for Wounds: Pain Relief or Excessive Scar Formation?

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
Wen-Hsiang Su ◽  
Ming-Huei Cheng ◽  
Wen-Ling Lee ◽  
Tsung-Shan Tsou ◽  
Wen-Hsun Chang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Transforming Growth Factor ◽  
Scar Formation ◽  
Normal Wound Healing ◽  
Mediators Of Inflammation ◽  
Aberrant Form ◽  
Inflammatory Drugs ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
Cox 2 Inhibitors

The inflammatory process has direct effects on normal and abnormal wound healing. Hypertrophic scar formation is an aberrant form of wound healing and is an indication of an exaggerated function of fibroblasts and excess accumulation of extracellular matrix during wound healing. Two cytokines—transforming growth factor-β(TGF-β) and prostaglandin E2 (PGE2)—are lipid mediators of inflammation involving wound healing. Overproduction of TGF-βand suppression of PGE2 are found in excessive wound scarring compared with normal wound healing. Nonsteroidal anti-inflammatory drugs (NSAIDs) or their selective cyclooxygenase-2 (COX-2) inhibitors are frequently used as a pain-killer. However, both NSAIDs and COX-2 inhibitors inhibit PGE2 production, which might exacerbate excessive scar formation, especially when used during the later proliferative phase. Therefore, a balance between cytokines and medication in the pathogenesis of wound healing is needed. This report is a literature review pertaining to wound healing and is focused on TGF-βand PGE2.

Reduction of paw edema and liver oxidative stress in carrageenan-induced acute inflammation by Lobaria pulmonaria and Parmelia caperata, lichen species, in mice

2019 ◽  
pp. 1-9
Author(s):  
Samira Salem ◽  
Essaid Leghouchi ◽  
Rachid Soulimani ◽  
Jaouad Bouayed
Keyword(s):  
Time Course ◽  
Acute Inflammation ◽  
Lichen Species ◽  
Paw Edema ◽  
Sod Activity ◽  
Edema Formation ◽  
Lobaria Pulmonaria ◽  
Anti Inflammatory ◽  
Endogenous Antioxidant ◽  
Inflammatory Effect

Abstract. Paw edema volume reduction is a useful marker in determining the anti-inflammatory effect of drugs and plant extracts in carrageenan-induced acute inflammation. In this study, the anti-inflammatory effect of Lobaria pulmonaria (LP) and Parmelia caperata (PC), two lichen species, was examined in carrageenan-induced mouse paw edema test. Compared to the controls in carrageenan-induced inflammation (n = 5/group), our results showed that pretreatment by single oral doses with PC extract (50–500 mg/kg) gives better results than LP extract (50–500 mg/kg) in terms of anti-edematous activity, as after 4 h of carrageenan subplantar injection, paw edema formation was inhibited at 82–99% by PC while at 35–49% by LP. The higher anti-inflammatory effect of PC, at all doses, was also observed on the time-course of carrageenan-induced paw edema, displaying profile closely similar to that obtained with diclofenac (25 mg/kg), an anti-inflammatory drug reference (all p < 0.001). Both LP and PC, at all doses, significantly ameliorated liver catalase (CAT) activity (all p < 0.05). However, superoxide dismutase (SOD) activity, glutathione peroxidase (GPx) activity and glutathione (GSH) levels were found increased in liver of PC- compared to LP-carrageenan-injected mice. Our findings demonstrated on one hand higher preventive effects of PC compared to LP in a mouse carrageenan-induced inflammatory model and suggested, on the other hand, that anti-inflammatory effects elicited by the two lichens were closely associated with the amelioration in the endogenous antioxidant status of liver.

An in vitro model for investigation of vitamin A effects on wound healing

2021 ◽  
pp. 1-6
Author(s):  
Hoda Keshmiri Neghab ◽  
Mohammad Hasan Soheilifar ◽  
Gholamreza Esmaeeli Djavid
Keyword(s):  
Wound Healing ◽  
Endothelial Cell ◽  
Vitamin A ◽  
In Vitro Model ◽  
Cellular Proliferation ◽  
Endothelial Cell Migration ◽  
Normal Fibroblast ◽  
Anti Inflammatory ◽  
Vitro Model

Abstract. Wound healing consists of a series of highly orderly overlapping processes characterized by hemostasis, inflammation, proliferation, and remodeling. Prolongation or interruption in each phase can lead to delayed wound healing or a non-healing chronic wound. Vitamin A is a crucial nutrient that is most beneficial for the health of the skin. The present study was undertaken to determine the effect of vitamin A on regeneration, angiogenesis, and inflammation characteristics in an in vitro model system during wound healing. For this purpose, mouse skin normal fibroblast (L929), human umbilical vein endothelial cell (HUVEC), and monocyte/macrophage-like cell line (RAW 264.7) were considered to evaluate proliferation, angiogenesis, and anti-inflammatory responses, respectively. Vitamin A (0.1–5 μM) increased cellular proliferation of L929 and HUVEC (p < 0.05). Similarly, it stimulated angiogenesis by promoting endothelial cell migration up to approximately 4 fold and interestingly tube formation up to 8.5 fold (p < 0.01). Furthermore, vitamin A treatment was shown to decrease the level of nitric oxide production in a dose-dependent effect (p < 0.05), exhibiting the anti-inflammatory property of vitamin A in accelerating wound healing. These results may reveal the therapeutic potential of vitamin A in diabetic wound healing by stimulating regeneration, angiogenesis, and anti-inflammation responses.

In vitro anti-inflammatory and wound healing activities of Citrus auraptene

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
F Epifano ◽  
S Genovese ◽  
L Zhao ◽  
V Dang La ◽  
D Grenier
Keyword(s):  
Wound Healing ◽  
Anti Inflammatory

Time course study of blood pressure in children over a three-year period. Bogalusa Heart Study

Hypertension ◽  
1980 ◽  
Vol 2 (4) ◽  
pp. 102-108 ◽  
Author(s):  
A. W. Voors ◽  
L. S. Webber ◽  
G. S. Berenson
Keyword(s):  
Blood Pressure ◽  
Time Course ◽  
Bogalusa Heart Study ◽  
Heart Study ◽  
Time Course Study
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