Failure of conjugated linoleic acid supplementation to enhance biosynthesis of docosahexaenoic acid from α-linolenic acid in healthy human volunteers

2007 ◽  
Vol 76 (3) ◽  
pp. 121-130 ◽  
Author(s):  
N.M. Attar-Bashi ◽  
R.S. Weisinger ◽  
D.P. Begg ◽  
D. Li ◽  
A.J. Sinclair
Keyword(s):  
Linoleic Acid ◽  
Docosahexaenoic Acid ◽  
Conjugated Linoleic Acid ◽  
Linolenic Acid ◽  
Healthy Human ◽  
Acid Supplementation ◽  
Human Volunteers

scholarly journals Effects of conjugated linoleic acid on linoleic and linolenic acid metabolism in man

2006 ◽  
Vol 95 (4) ◽  
pp. 727-733 ◽  
Author(s):  
Anu M. Turpeinen ◽  
Sonja Bärlund ◽  
Riitta Freese ◽  
Peter Lawrence ◽  
Thomas Brenna
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Linolenic Acid ◽  
Animal Studies ◽  
Peak Plasma ◽  
Human Subjects ◽  
Essential Fatty Acids ◽  
Daily Intake ◽  
Area Under The Curve ◽  
Healthy Human

Evidence from animal studies suggests that conjugated linoleic acid (CLA) modulates plasma and tissue appearance of newly synthesized PUFA. The effects of a 1·2g (0·5% energy) daily intake of the cis-9, trans-11 (c9, t11) isomer of CLA, trans-10,cis-12 (t10, c12) isomer of CLA or olive oil (placebo) on linoleic acid (LA) and linolenic acid (LNA) metabolism in healthy human volunteers was investigated. Fifteen subjects were fed an experimental diet and supplemented with c9,t11-CLA, t10, c12-CLA or placebo for 7d before consuming a tracer dose of U-[13C]La (50%Mg) And U-[13C]Lna (50Mg). Blood Samples Were Taken At 0, 2, 4, 6, 8, 24, 48, 72 and 168%h and analysed using high-precision MS. No differences between the groups in peak plasma [13C]LA (10·3–11·6% of dose), [13C]LNA (2·5–2·9% of dose), [13C]arachidonic acid (0·09–0·12% of dose), [13C]EPA (0·04–0·06% of dose) or [13C]Dha (0c·06–0·10% of dose) were detected. Concentration V. time curves (area under the curve) also showed no significant differences between groups. This suggests that, in healthy human subjects consuming a diet with adequate intake of essential fatty acids, CLA does not affect metabolism of LA or LNA

Effects of conjugated linoleic acid supplementation on blood lipids and adiposity of rats fed diets rich in saturated versus unsaturated fat

2005 ◽  
Vol 51 (6) ◽  
pp. 503-507 ◽  
Author(s):  
Rebecca Kloss ◽  
Janna Linscheid ◽  
Amy Johnson ◽  
Brian Lawson ◽  
Kylie Edwards ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Blood Lipids ◽  
Acid Supplementation ◽  
Unsaturated Fat

Safety of conjugated linoleic acid (CLA) in overweight or obese human volunteers

2000 ◽  
Vol 102 (7) ◽  
pp. 455-462 ◽  
Author(s):  
Grethe Berven ◽  
Amund Bye ◽  
Ottar Hals ◽  
Henrietta Blankson ◽  
Hans Fagertun ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Human Volunteers ◽  
Obese Human

Effects of rumenic acid rich conjugated linoleic acid supplementation on cognitive function and handgrip performance in older men and women

2016 ◽  
Vol 84 ◽  
pp. 1-11 ◽  
Author(s):  
Nathaniel D.M. Jenkins ◽  
Terry J. Housh ◽  
Amelia A. Miramonti ◽  
Brianna D. McKay ◽  
Noelle M. Yeo ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Cognitive Function ◽  
Conjugated Linoleic Acid ◽  
Older Men ◽  
Men And Women ◽  
Acid Supplementation ◽  
Older Men And Women

Independent effects of dietary linoleic and linolenic fatty acids on the conjugated linoleic acid content of cows’ milk

2002 ◽  
Vol 74 (1) ◽  
pp. 163-176 ◽  
Author(s):  
A.L. Lock ◽  
P.C. Garnsworthy
Keyword(s):  
Fatty Acids ◽  
Mammary Gland ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Linolenic Acid ◽  
Milk Fat ◽  
Latin Square ◽  
Health Benefit ◽  
Low Linolenic Acid ◽  
Low Linolenic

AbstractIt may be desirable to increase the level of conjugated linoleic acid (CLA) in milk as a health benefit in human nutrition. The purpose of this work was to separate the effects of linoleic and linolenic acids on CLA production in dairy cows and to determine to what extent endogenous synthesis contributes to cis-9, trans-11 CLA concentration in milk fat. Eight lactating cows and four non-lactating duodenal fistulated cows were used in a 4 ✕ 4 Latin-square design. All cows received a basal diet of grass silage that was supplemented with one of four concentrates, which were designed to differ in their linoleic and linolenic acid contents. The oil components of the concentrates were produced from mixtures of olive, linseed, rape, soya and sunflower oils to produce the four treatments: low linoleic/ low linolenic acid (LL), low linoleic/high linolenic acid (LH), high linoleic/low linolenic acid (HL) and high linoleic/ high linolenic acid (HH). Milk cis-9, trans-11 CLA contents were 0·8, 0·9, 0·9 and 1·1 g/100 g fatty acid methyl esters (P < 0·05) and yields were 5, 7, 7 and 8 g/day (P < 0·05) for the LL, LH, HL and HH treatments, respectively. The yields of trans-C18:1 fatty acids in milk were 19, 22, 21 and 23 g/day (P < 0·05), respectively. Taking the data for the cis-9, trans-11 CLA content and flow of duodenal fluid from the fistulated cows and representing this in terms of dietary intake by the lactating animals, the amounts of cis-9, trans-11 CLA produced in the rumen were calculated to be 0·8, 0·9, 1·2 and 1·1 g/day (P < 0·05) and for trans-C18:1 fatty acids 58, 58, 66 and 69 g/day (P < 0·05). Increasing linoleic and/or linolenic acids in the diet can increase the cis-9, trans-11 CLA content of cows’ milk. Only diets high in linoleic acid increased cis-9, trans-11 CLA production in the rumen. On all four diets, more than 80% of cis-9, trans-11 CLA in milk was produced endogenously by Δ9-desaturase from trans-11 C18:1 in the mammary gland. Cows on the same diet have different milk fat cis-9, trans-11 CLA concentrations that may be partially explained by differences in Δ9-desaturase activity between cows. Increasing the activity of Δ9-desaturase in the mammary gland may offer greater potential for enhancing the cis-9, trans-11 CLA content of milk fat than increasing cis-9, trans-11 CLA production in the rumen.

Sign in / Sign up

Export Citation Format

Share Document