Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARγ in human colon cancer Caco-2 cells

2005 ◽  
Vol 73 (2) ◽  
pp. 113-119 ◽  
Author(s):  
Yumiko Yasui ◽  
Masashi Hosokawa ◽  
Takehiko Sahara ◽  
Rikako Suzuki ◽  
Satoru Ohgiya ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Fatty Acid ◽  
Linolenic Acid ◽  
Human Colon ◽  
Bitter Gourd ◽  
Conjugated Linolenic Acid ◽  
Human Colon Cancer ◽  
Seed Fatty Acid

scholarly journals [Corrigendum] A combination of inhibitors of glycolysis, glutaminolysis and de�novo fatty acid synthesis decrease the expression of chemokines in human colon cancer cells

2020 ◽  
Author(s):  
Alejandro Schcolnik‑Cabrera ◽  
Guadalupe Dominguez‑G�mez ◽  
Alma Ch�vez‑Blanco ◽  
Marisol Ram�rez‑Yautentzi ◽  
Roc�o Morales‑B�rcenas ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Fatty Acid ◽  
Cancer Cells ◽  
Fatty Acid Synthesis ◽  
De Novo ◽  
Human Colon ◽  
Acid Synthesis ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

scholarly journals A combination of inhibitors of glycolysis, glutaminolysis and de�novo fatty acid synthesis decrease the expression of chemokines in human colon cancer cells

2019 ◽  
Author(s):  
Alejandro Schcolnik‑Cabrera ◽  
Guadalupe Dominguez‑G�mez ◽  
Alma Ch�vez‑Blanco ◽  
Marisol Ram�rez‑Yautentzi ◽  
Roc�o Morales‑B�rcenas ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Fatty Acid ◽  
Cancer Cells ◽  
Fatty Acid Synthesis ◽  
De Novo ◽  
Human Colon ◽  
Acid Synthesis ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

scholarly journals The Microbe-Derived Short Chain Fatty Acid Butyrate Targets miRNA-Dependent p21 Gene Expression in Human Colon Cancer

PLoS ONE ◽  
2011 ◽  
Vol 6 (1) ◽  
pp. e16221 ◽  
Author(s):  
Shien Hu ◽  
Tien Sy Dong ◽  
Sushila R. Dalal ◽  
Feng Wu ◽  
Marc Bissonnette ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colon Cancer ◽  
Fatty Acid ◽  
Short Chain Fatty Acid ◽  
Human Colon ◽  
Chain Fatty Acid ◽  
Short Chain ◽  
Human Colon Cancer

scholarly journals Decreased Polyunsaturated Fatty Acid Content Contributes to Increased Survival in Human Colon Cancer

2009 ◽  
Vol 2009 ◽  
pp. 1-9 ◽  
Author(s):  
Manuela Oraldi ◽  
Antonella Trombetta ◽  
Fiorella Biasi ◽  
Rosa A. Canuto ◽  
Marina Maggiora ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Colon Cancer ◽  
Arachidonic Acid ◽  
Fatty Acid ◽  
Cell Line ◽  
Fatty Acid Content ◽  
Human Colon ◽  
Dependent Manner ◽  
Human Colon Cancer ◽  
Cox 2

Among diet components, some fatty acids are known to affect several stages of colon carcinogenesis, whereas others are probably helpful in preventing tumors. In light of this, our aim was to determine the composition of fatty acids and the possible correlation with apoptosis in human colon carcinoma specimens at different Duke's stages and to evaluate the effect of enriching human colon cancer cell line with the possible reduced fatty acid(s). Specimens of carcinoma were compared with the corresponding non-neoplastic mucosa: a significant decrease of arachidonic acid, PPARα, Bad, and Bax and a significant increase of COX-2, Bcl-2, and pBad were found. The importance of arachidonic acid in apoptosis was demonstrated by enriching a Caco-2 cell line with this fatty acid. It induced apoptosis in a dose- and time-dependent manner via induction of PPARαthat, in turn, decreased COX-2. In conclusion, the reduced content of arachidonic acid is likely related to carcinogenic process decreasing the susceptibility of cancer cells to apoptosis.

Leptin is a growth factor for human colon cancer cells

2001 ◽  
Vol 120 (5) ◽  
pp. A493-A493
Author(s):  
J HARDWICK ◽  
G VANDENBRINK ◽  
S VANDEVENTER ◽  
M PEPPELENBOSCH
Keyword(s):  
Colon Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells
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