In vivo magnetic resonance spectroscopy in chronic fatigue syndrome

2004 ◽  
Vol 71 (3) ◽  
pp. 181-183 ◽  
Author(s):  
A Chaudhuri ◽  
P.O Behan
Keyword(s):  
Magnetic Resonance ◽  
Chronic Fatigue Syndrome ◽  
Magnetic Resonance Spectroscopy ◽  
Chronic Fatigue ◽  
Resonance Spectroscopy ◽  
Fatigue Syndrome

scholarly journals Neurochemical abnormalities in chronic fatigue syndrome: a pilot magnetic resonance spectroscopy study at 7 Tesla

2021 ◽  
Author(s):  
Beata R. Godlewska ◽  
Stephen Williams ◽  
Uzay E. Emir ◽  
Chi Chen ◽  
Ann L. Sharpley ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Chronic Fatigue Syndrome ◽  
Magnetic Resonance Spectroscopy ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Chronic Fatigue ◽  
Anterior Cingulate ◽  
7 Tesla ◽  
Resonance Spectroscopy ◽  
Fatigue Syndrome

Abstract Rationale Chronic fatigue syndrome (CFS) is a common and burdensome illness with a poorly understood pathophysiology, though many of the characteristic symptoms are likely to be of brain origin. The use of high-field proton magnetic resonance spectroscopy (MRS) enables the detection of a range of brain neurochemicals relevant to aetiological processes that have been linked to CFS, for example, oxidative stress and mitochondrial dysfunction. Methods We studied 22 CFS patients and 13 healthy controls who underwent MRS scanning at 7 T with a voxel placed in the anterior cingulate cortex. Neurometabolite concentrations were calculated using the unsuppressed water signal as a reference. Results Compared to controls, CFS patients had lowered levels of glutathione, total creatine and myo-inositol in anterior cingulate cortex. However, when using N-acetylaspartate as a reference metabolite, only myo-inositol levels continued to be significantly lower in CFS participants. Conclusions The changes in glutathione and creatine are consistent with the presence of oxidative and energetic stress in CFS patients and are potentially remediable by nutritional intervention. A reduction in myo-inositol would be consistent with glial dysfunction. However, the relationship of the neurochemical abnormalities to the causation of CFS remains to be established, and the current findings require prospective replication in a larger sample.

Heterogeneity in chronic fatigue syndrome: evidence from magnetic resonance spectroscopy of muscle

1998 ◽  
Vol 8 (3-4) ◽  
pp. 204-209 ◽  
Author(s):  
Russell J.M Lane ◽  
Michael C Barrett ◽  
Doris J Taylor ◽  
Graham J Kemp ◽  
Raffaele Lodi
Keyword(s):  
Magnetic Resonance ◽  
Chronic Fatigue Syndrome ◽  
Magnetic Resonance Spectroscopy ◽  
Chronic Fatigue ◽  
Resonance Spectroscopy ◽  
Fatigue Syndrome

Biological NMR Spectroscopy

1997 ◽  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Nmr Spectroscopy ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
State Of The Art ◽  
Critical Assessment ◽  
Resonance Spectroscopy ◽  
History Of ◽  
Structure Of Proteins

This book presents a critical assessment of progress on the use of nuclear magnetic resonance spectroscopy to determine the structure of proteins, including brief reviews of the history of the field along with coverage of current clinical and in vivo applications. The book, in honor of Oleg Jardetsky, one of the pioneers of the field, is edited by two of the most highly respected investigators using NMR, and features contributions by most of the leading workers in the field. It will be valued as a landmark publication that presents the state-of-the-art perspectives regarding one of today's most important technologies.

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