Fatty acid transporter expression is decreased in placental macrovascular endothelial cells, but not trophoblasts, in obese women

Placenta ◽  
2016 ◽  
Vol 45 ◽  
pp. 132
Author(s):  
Xiaohua Yang ◽  
Patricia Glazebrook ◽  
Maricela Haghiac ◽  
Judi Minium ◽  
Sylvie Hauguel deMouzon ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Fatty Acid ◽  
Obese Women ◽  
Fatty Acid Transporter ◽  
Acid Transporter ◽  
Transporter Expression

scholarly journals Fatty acid transporter expression and regulation is impaired in placental macrovascular endothelial cells in obese women

2017 ◽  
Vol 32 (6) ◽  
pp. 971-978 ◽  
Author(s):  
Xiaohua Yang ◽  
Patricia Glazebrook ◽  
Geraldine C. Ranasinghe ◽  
Maricela Haghiac ◽  
Virtu Calabuig-Navarro ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Fatty Acid ◽  
Obese Women ◽  
Fatty Acid Transporter ◽  
Acid Transporter ◽  
Transporter Expression

scholarly journals Changes in the Diaphragm Lipid Content after Administration of Streptozotocin and High-Fat Diet Regime

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Bartlomiej Lukaszuk ◽  
Agnieszka Miklosz ◽  
Malgorzata Zendzian-Piotrowska ◽  
Beata Wojcik ◽  
Jan Gorski ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acid ◽  
High Fat Diet ◽  
High Fat ◽  
Ceramide Synthesis ◽  
Male Wistar Rats ◽  
Fatty Acid Transporter ◽  
Acid Transporter ◽  
Fatty Acid Species ◽  
Transporter Expression

The diaphragm is a dome-shaped skeletal muscle indispensable for breathing. Its activity contributes up to 70% of the total ventilatory function at rest. In comparison to other skeletal muscles, it is distinguished by an oxidative phenotype and uninterrupted cyclic contraction pattern. Surprisingly, the research regarding diaphragm diabetic phenotype particularly in the light of lipid-induced insulin resistance is virtually nonexistent. Male Wistar rats were randomly allocated into 3 groups: control, streptozotocin-induced (STZ) type-1 diabetes, and rodents fed with high-fat diet (HFD). Additionally, half of the animals from each group were administered with myriocin, a robust, selective inhibitor of ceramide synthesis and, therefore, a potent agent ameliorating insulin resistance. Diaphragm lipid contents were evaluated using chromatography. Fatty acid transporter expression was determined by Western blot. The STZ and HFD rats had increased concentration of lipids, namely, ceramides (CER) and diacylglycerols (DAG). Interestingly, this coincided with an increased concentration of long-chain (C ≥ 16) saturated fatty acid species present in both the aforementioned lipid fractions. The CER/DAG accumulation was accompanied by an elevated fatty acid transporter expression (FATP-1 in HFD and FATP-4 in STZ). Surprisingly, we observed a significantly decreased triacylglycerol content in the diaphragms of STZ-treated rats.

scholarly journals Fatty acid transporter expression in human myocytes

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Jill A Bell ◽  
Melissa A Reed ◽  
Deborah M Muoio ◽  
G. Lynis Dohm
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Transporter ◽  
Acid Transporter ◽  
Transporter Expression

scholarly journals Developmental Accretion of Docosahexaenoic Acid Is Independent of Fatty Acid Transporter Expression in Brain and Lung Tissues of C57BL/6 and Fat1 Mice

2019 ◽  
Vol 149 (10) ◽  
pp. 1724-1731 ◽  
Author(s):  
William Yakah ◽  
Pratibha Singh ◽  
George Perides ◽  
Joanne Brown ◽  
Steven D Freedman ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Docosahexaenoic Acid ◽  
Corn Oil ◽  
Postnatal Period ◽  
Developmental Expression ◽  
Developmentally Regulated ◽  
Tissue Specific ◽  
Fatty Acid Transporter ◽  
Acid Transporter ◽  
Transporter Expression

ABSTRACT Background Developmental expression of fatty acid transporters and their role in polyunsaturated fatty acid concentrations in the postnatal period have not been evaluated. Objective We hypothesized that transporter expression is developmentally regulated, tissue-specific, and that expression can modulate fatty acid accretion independently of diet. Methods Brain and lung transporter expression were quantified in C57BL/6 wild-type (WT) and Fat1 mice. Pups were dam-fed until day 21. Dams were fed AIN-76A 10% corn oil to represent a typical North American/European diet. After weaning, mice were fed the same diet as dams. Gene expression of Fatp1, Fatp4, Fabp5, and Fat/cd36 was quantified by quantitative reverse transcriptase-polymerase chain reaction. Fatty acid concentrations were measured by GC–MS. Results Brain docosahexaenoic acid (DHA) concentrations increased from day 3 to day 28 in both genotypes, with higher concentrations at days 3 and 14 in Fat1 than in WT mice [median (IQR)]: 10.7 (10.6–11.2) mol% compared with 6.6 (6.4–7.2) mol% and 12.5 (12.4–12.9) mol% compared with 8.9 (8.7–9.1) mol%, respectively; P < 0.05). During DHA accrual, transporter expression decreased. Fold changes in brain Fatp4, Fabp5, and Fat/cd36 were inversely correlated with fold changes in brain DHA concentrations in Fat1 relative to WT mice (ρ = −0.85, −0.75, and −0.78, respectively; P ≤ 0.001). Lung DHA concentrations were unchanged across the 3 time points for both genotypes. Despite unchanging DHA concentrations, there was increased expression of Fatp1 at days 14 and 28 (5-fold), Fatp4 at day 14 (2.3-fold), and Fabp5 at day 14 (3.8-fold) relative to day 3 in Fat1 mice. In WT mice, Fatp1 increased almost 5-fold at day 28 relative to day 3. There was no correlation between lung transporters and DHA concentrations in Fat1 relative to WT mice. Conclusions Development of fatty acid transporter expression in C57BL/6 WT and Fat1 mice is genotype and tissue specific. Further, postnatal accretion of brain DHA appears independent of transporter status, with tissue concentrations representing dietary contributions.

scholarly journals Hyperinsulinemia Enhances Hepatic Expression of the Fatty Acid Transporter Cd36 and Provokes Hepatosteatosis and Hepatic Insulin Resistance

2015 ◽  
Vol 290 (31) ◽  
pp. 19034-19043 ◽  
Author(s):  
Pär Steneberg ◽  
Alexandros G. Sykaras ◽  
Fredrik Backlund ◽  
Jurate Straseviciene ◽  
Ingegerd Söderström ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acid ◽  
Hepatic Insulin Resistance ◽  
Hepatic Expression ◽  
Fatty Acid Transporter ◽  
Acid Transporter
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