Glucocorticoids modulate expression and function of the multidrug resistance transporters in the 1st trimester human placenta

Placenta ◽  
2016 ◽  
Vol 45 ◽  
pp. 130
Author(s):  
Phetcharawan Lye ◽  
Lubna Nadeem ◽  
Jeremy Landry ◽  
William Gibb ◽  
Stephen Lye ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Human Placenta ◽  
Multidrug Resistance Transporters ◽  
And Function

scholarly journals Glucocorticoids modulate multidrug resistance transporters in the first trimester human placenta

2018 ◽  
Vol 22 (7) ◽  
pp. 3652-3660 ◽  
Author(s):  
Phetcharawan Lye ◽  
Enrrico Bloise ◽  
Lubna Nadeem ◽  
William Gibb ◽  
Stephen J. Lye ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Human Placenta ◽  
First Trimester ◽  
Multidrug Resistance Transporters

Differential Multidrug Resistance-Associated Protein 1 through 6 Isoform Expression and Function in Human Intestinal Epithelial Caco-2 Cells

2004 ◽  
Vol 311 (2) ◽  
pp. 476-484 ◽  
Author(s):  
Hannah M. Prime-Chapman ◽  
Richard A. Fearn ◽  
Anne E. Cooper ◽  
Vanessa Moore ◽  
Barry H. Hirst
Keyword(s):  
Multidrug Resistance ◽  
Intestinal Epithelial ◽  
Isoform Expression ◽  
And Function

scholarly journals The Ontogeny and Function of Placental Macrophages

2021 ◽  
Vol 12 ◽  
Author(s):  
Jake R. Thomas ◽  
Praveena Naidu ◽  
Anna Appios ◽  
Naomi McGovern
Keyword(s):  
Human Placenta ◽  
Outer Layer ◽  
New Technologies ◽  
Placental Development ◽  
Fetal Health ◽  
Hofbauer Cells ◽  
Recent Developments ◽  
Placental Macrophages ◽  
And Function ◽  
Insight Into

The placenta is a fetal-derived organ whose function is crucial for both maternal and fetal health. The human placenta contains a population of fetal macrophages termed Hofbauer cells. These macrophages play diverse roles, aiding in placental development, function and defence. The outer layer of the human placenta is formed by syncytiotrophoblast cells, that fuse to form the syncytium. Adhered to the syncytium at sites of damage, on the maternal side of the placenta, is a population of macrophages termed placenta associated maternal macrophages (PAMM1a). Here we discuss recent developments that have led to renewed insight into our understanding of the ontogeny, phenotype and function of placental macrophages. Finally, we discuss how the application of new technologies within placental research are helping us to further understand these cells.

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