Susceptibility to Vertical Transmission of Toxoplasma gondii is Temporally Dependent on the Preconceptional Infection in Calomys callosus

Placenta ◽  
2007 ◽  
Vol 28 (7) ◽  
pp. 624-630 ◽  
Author(s):  
B.F. Barbosa ◽  
D.A.O. Silva ◽  
I.N. Costa ◽  
J.D.O. Pena ◽  
J.R. Mineo ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Vertical Transmission ◽  
Calomys Callosus

scholarly journals Calomys callosus chronically infected by Toxoplasma gondii clonal type II strain and reinfected by Brazilian strains is not able to prevent vertical transmission

2015 ◽  
Vol 6 ◽  
Author(s):  
Priscila S. Franco ◽  
Neide M. da Silva ◽  
Bellisa de Freitas Barbosa ◽  
Angelica de Oliveira Gomes ◽  
Francesca Ietta ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Vertical Transmission ◽  
Type Ii ◽  
Clonal Type ◽  
Calomys Callosus

scholarly journals Evaluation of vertical transmission of Toxoplasma gondii in Calomys callosus model after reinfection with heterologous and virulent strain

Placenta ◽  
2011 ◽  
Vol 32 (2) ◽  
pp. 116-120 ◽  
Author(s):  
P.S. Franco ◽  
D.A.O. Silva ◽  
I.N. Costa ◽  
A.O. Gomes ◽  
A.L.N. Silva ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Vertical Transmission ◽  
Virulent Strain ◽  
Calomys Callosus

scholarly journals Azithromycin Inhibits Vertical Transmission of Toxoplasma gondii in Calomys callosus (Rodentia: Cricetidae)

Placenta ◽  
2009 ◽  
Vol 30 (10) ◽  
pp. 884-890 ◽  
Author(s):  
I.N. Costa ◽  
M.B. Angeloni ◽  
L.A. Santana ◽  
B.F. Barbosa ◽  
M.C.P. Silva ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Vertical Transmission ◽  
Calomys Callosus

scholarly journals Treatment with Bumped Kinase Inhibitor 1294 Is Safe and Leads to Significant Protection against Abortion and Vertical Transmission in Sheep Experimentally Infected with Toxoplasma gondii during Pregnancy

2019 ◽  
Vol 63 (7) ◽  
Author(s):  
Roberto Sánchez-Sánchez ◽  
Ignacio Ferre ◽  
Michela Re ◽  
Juan José Ramos ◽  
Javier Regidor-Cerrillo ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Vertical Transmission ◽  
Kinase Inhibitor ◽  
Plasma Concentrations ◽  
Systemic Exposure ◽  
Fetal Mortality ◽  
Maximum Plasma ◽  
Content Type ◽  
Pregnant Sheep

ABSTRACT Previous studies on drug efficacy showed low protection against abortion and vertical transmission of Toxoplasma gondii in pregnant sheep. Bumped kinase inhibitors (BKIs), which are ATP-competitive inhibitors of calcium-dependent protein kinase 1 (CDPK1), were shown to be highly efficacious against several apicomplexan parasites in vitro and in laboratory animal models. Here, we present the safety and efficacy of BKI-1294 treatment (dosed orally at 100 mg/kg of body weight 5 times every 48 h) initiated 48 h after oral infection of sheep at midpregnancy with 1,000 TgShSp1 oocysts. BKI-1294 demonstrated systemic exposure in pregnant ewes, with maximum plasma concentrations of 2 to 3 μM and trough concentrations of 0.4 μM at 48 h after each dose. Oral administration of BKI-1294 in uninfected sheep at midpregnancy was deemed safe, since there were no changes in behavior, fecal consistency, rectal temperatures, hematological and biochemical parameters, or fetal mortality/morbidity. In ewes infected with a T. gondii oocyst dose lethal for fetuses, BKI-1294 treatment led to a minor rectal temperature increase after infection and a decrease in fetal/lamb mortality of 71%. None of the lambs born alive in the treated group exhibited congenital encephalitis lesions, and vertical transmission was prevented in 53% of them. BKI-1294 treatment during infection led to strong interferon gamma production after cell stimulation in vitro and a low humoral immune response to soluble tachyzoite antigens but high levels of anti-SAG1 antibodies. The results demonstrate a proof of concept for the therapeutic use of BKI-1294 to protect ovine fetuses from T. gondii infection during pregnancy.

scholarly journals Cytomegalovirus, toxoplasma gondii and rubella vertical transmission rates according to mid-trimester amniocentesis: A retrospective study

2015 ◽  
Vol 6 (1) ◽  
pp. 32 ◽  
Author(s):  
Stamatios Petousis ◽  
Stella Prapa ◽  
Themistoklis Dagklis ◽  
Apostolos Mamopoulos ◽  
Nikos Prapas ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Toxoplasma Gondii ◽  
Vertical Transmission ◽  
Transmission Rates

Calomys callosus (Rodentia: Cricetidae) trophoblast cells as host cells to Toxoplasma gondii in early pregnancy

1999 ◽  
Vol 85 (8-9) ◽  
pp. 647-654 ◽  
Author(s):  
E. A. V. Ferro ◽  
E. Bevilacqua ◽  
S. Favoreto-Junior ◽  
D. A. O. Silva ◽  
R. A. Mortara ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Early Pregnancy ◽  
Host Cells ◽  
Trophoblast Cells ◽  
Calomys Callosus

scholarly journals Evidence for high levels of vertical transmission in Toxoplasma gondii

Parasitology ◽  
2009 ◽  
Vol 136 (14) ◽  
pp. 1877-1885 ◽  
Author(s):  
G. HIDE ◽  
E. K. MORLEY ◽  
J. M. HUGHES ◽  
O. GERWASH ◽  
M. S. ELMAHAISHI ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Recent Work ◽  
Natural Population ◽  
Vertical Transmission ◽  
Definitive Host ◽  
Natural Populations ◽  
Relative Importance ◽  
Congenital Transmission ◽  
Transmission Rates ◽  
Almost All

SUMMARYToxoplasma gondii is a highly ubiquitous and prevalent parasite. Despite the cat being the only definitive host, it is found in almost all geographical areas and warm blooded animals. Three routes of transmission are recognised: ingestion of oocysts shed by the cat, carnivory and congenital transmission. In natural populations, it is difficult to establish the relative importance of these routes. This paper reviews recent work in our laboratory which suggests that congenital transmission may be much more important than previously thought. Using PCR detection of the parasite, studies in sheep show that congenital transmission may occur in as many as 66% of pregnancies. Furthermore, in families of sheep on the same farm, exposed to the same sources of oocysts, significant divergent prevalences of Toxoplasma infection and abortion are found between different families. The data suggest that breeding from infected ewes increases the risk of subsequent abortion and infection in lambs. Congenital transmission rates in a natural population of mice were found to be 75%. Interestingly, congenital transmission rates in humans were measured at 19·8%. The results presented in these studies differ from those of other published studies and suggest that vertical transmission may be much more important than previously thought.

Mast cells in the eyes of Calomys callosus (Rodentia: Cricetidae) infected by Toxoplasma gondii

2002 ◽  
Vol 88 (6) ◽  
pp. 557-562 ◽  
Author(s):  
Cristiane D. Gil ◽  
José R. Mineo ◽  
Ricardo L. Smith ◽  
Sonia M. Oliani
Keyword(s):  
Mast Cells ◽  
Toxoplasma Gondii ◽  
Calomys Callosus
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