Congenital dengue infection: Are we missing the diagnosis?

2016 ◽  
Vol 8 (4) ◽  
pp. 120-123 ◽  
Author(s):  
Ramani Ranjan ◽  
Kishore Kumar ◽  
Nandini Nagar
Keyword(s):  
Dengue Infection

High Levels of Serum Hyaluronan Predicts Severe Dengue Infection and Perturbs Vascular Integrity

2019 ◽  
Author(s):  
Chun-Yu Lin ◽  
Constantinos Kolliopoulos ◽  
Chung-Hao Huang ◽  
Jyrki Tenhunen ◽  
Carl-Henrik Heldin ◽  
...  
Keyword(s):  
Dengue Infection ◽  
Severe Dengue ◽  
Vascular Integrity ◽  
Serum Hyaluronan

scholarly journals The Lethal(2)-Essential-for-Life [L(2)EFL] Gene Family Modulates Dengue Virus Infection in Aedes aegypti

2020 ◽  
Vol 21 (20) ◽  
pp. 7520
Author(s):  
Lucky R. Runtuwene ◽  
Shuichi Kawashima ◽  
Victor D. Pijoh ◽  
Josef S. B. Tuda ◽  
Kyoko Hayashida ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Dengue Virus ◽  
Cell Line ◽  
Dengue Infection ◽  
Fruit Fly ◽  
Initiation Factor ◽  
Poly I:C ◽  
Gene Products ◽  
Vector Mosquito

Efforts to determine the mosquito genes that affect dengue virus replication have identified a number of candidates that positively or negatively modify amplification in the invertebrate host. We used deep sequencing to compare the differential transcript abundances in Aedes aegypti 14 days post dengue infection to those of uninfected A. aegypti. The gene lethal(2)-essential-for-life [l(2)efl], which encodes a member of the heat shock 20 protein (HSP20) family, was upregulated following dengue virus type 2 (DENV-2) infection in vivo. The transcripts of this gene did not exhibit differential accumulation in mosquitoes exposed to insecticides or pollutants. The induction and overexpression of l(2)efl gene products using poly(I:C) resulted in decreased DENV-2 replication in the cell line. In contrast, the RNAi-mediated suppression of l(2)efl gene products resulted in enhanced DENV-2 replication, but this enhancement occurred only if multiple l(2)efl genes were suppressed. l(2)efl homologs induce the phosphorylation of eukaryotic initiation factor 2α (eIF2α) in the fruit fly Drosophila melanogaster, and we confirmed this finding in the cell line. However, the mechanism by which l(2)efl phosphorylates eIF2α remains unclear. We conclude that l(2)efl encodes a potential anti-dengue protein in the vector mosquito.

scholarly journals Evaluation of the extended efficacy of the Dengvaxia vaccine against symptomatic and subclinical dengue infection

2021 ◽  
Author(s):  
Henrik Salje ◽  
Maria Theresa Alera ◽  
Mary Noreen Chua ◽  
Taweewun Hunsawong ◽  
Damon Ellison ◽  
...  
Keyword(s):  
Dengue Infection
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