Pediatric solitary cysticercosis in buccal mucosa

2016 ◽  
Vol 8 (4) ◽  
pp. 118-119
Author(s):  
Jyoti K. Kudrimoti ◽  
Neeta A. Wahane ◽  
Shailaja C. Puranik
Keyword(s):  
Buccal Mucosa

175: Combined Buccal Mucosa Graft and Local Flap for Urethral Reconstruction in Female Transsexuals

2007 ◽  
Vol 177 (4S) ◽  
pp. 59-59
Author(s):  
Miroslav L. Ojordjevic ◽  
Sava V. Perovic ◽  
Harold M. Reed
Keyword(s):  
Buccal Mucosa ◽  
Local Flap ◽  
Urethral Reconstruction ◽  
Buccal Mucosa Graft

69: Development and Characterisation of Tissue-Engineered Buccal Mucosa for Urethroplasty

2004 ◽  
Vol 171 (4S) ◽  
pp. 18-18
Author(s):  
Saurabh Bhargava ◽  
Christopher R. Chapple ◽  
Anthony J. Bullock ◽  
Sheila MacNeil
Keyword(s):  
Buccal Mucosa

scholarly journals Amorphous Ropinirole-Loaded Mucoadhesive Buccal Film: A Potential Patient-Friendly Tool to Improve Drug Pharmacokinetic Profile and Effectiveness

2020 ◽  
Vol 10 (4) ◽  
pp. 242
Author(s):  
Giulia Di Prima ◽  
Giuseppina Campisi ◽  
Viviana De Caro
Keyword(s):  
Buccal Mucosa ◽  
Therapeutic Strategy ◽  
Therapeutic Response ◽  
Ex Vivo ◽  
Hepatic Metabolism ◽  
Pharmacokinetic Profile ◽  
Promising Candidate ◽  
Steady State Condition ◽  
Drug Pharmacokinetic ◽  
Drug Flux

Nowadays the therapeutic strategies to manage Parkinson’s Disease are merely symptomatic and consist of administering L-DOPA and/or dopamine receptor agonists. Among these, Ropinirole (ROP) is a widely orally-administered molecule, although it is extensively susceptible to hepatic metabolism. Since literature reports the buccal mucosa as a potentially useful route to ROP administration, the development of novel, effective, and comfortable oromucosal formulations should prove desirable in order to both enhance the therapeutic efficacy of the drug and allow a personalized therapeutic strategy able to meet the patient’s needs. The results of the proposed ROP film as a new dosage form show that it is flexible; uniform; and characterized by suitable surface pH; good mucoadhesiveness; low swelling degree; and fast, complete drug release. Moreover, after ex vivo evaluation on a film having an area of 0.282 cm2 and dose of 2.29 mg, the results of drug flux through the buccal mucosa are closely comparable to the amount of ROP that reaches the bloodstream at the steady-state condition after ROP-PR 4 mg oral administration, calculated according to the literature (0.237 mg/cm2·h−1 vs. 0.243 mg/h, respectively). Moreover, drug flux and ROP dose could be accurately modulated time-by-time depending on the patient’s need, by varying the administered disk area. In addition, the proposed ROP film displays no lag time, producing an immediate drug input in the bloodstream, which could result in a prompt therapeutic response. These findings make ROP film a potentially comfortable and patient-friendly formulation, and a promising candidate for further clinical trials.

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